Noninvasive evaluation of mediastinal metastases in bronchogenic carcinoma: A prospective comparison of chest radiography and gallium-67 scanning

Lunia, Shanti L.; Ruckdeschel, John C.; McKneally, Martin F.; Killam, Donald; Baxter, Donald H.; Kellar, Sarah; Ray, P.; McIlduff, Joseph B.; Lininger, Lloyd; Chodos, Robert B.; Horton, John

doi:10.1002/1097-0142(19810215)47:4<672::aid-cncr2820470409>3.0.co;2-1

Cited by 28 publications

(3 citation statements)

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“…It is important because it would be cost-effective, especially in the case of potentially resectable lesions. Lunia et al [46] also reported that 67Ga scanning was more accurate than chest radiography for the assessment of regional nodes (overall accuracy, 85% vs 56%, P<0.05). Similar results were reported by Fosburg and co-workers [45], who found that 67Ga imaging was more sensitive (88%) than mediastinal tomography (81%) and chest radiography (75%) in assessing mediastinal disease.…”

Section: Value For Detection Of Mediastinal Involvementmentioning

confidence: 97%

“…Other studies by Langhammer, Kempken and Van der Schoot [62][63][64] showed no relationship between the intensity of Ga uptake and the histological type of the tumor. The whole-body 67Ga scan is occasionally useful for the detection of extrapulmonary metastases [46,53]. 67Ga scanning has also been evaluated for the detection of extrathoracic spread of lung carcinoma.…”

Section: Relationship Between 67ga Uptake and Histological Typementioning

confidence: 99%

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Tracer imaging in lung cancer

et al. 1994

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Lung cancer is the leading cause of death from cancer in males. Adequate staging is essential if proper treatment is to be administered. Current morphological imaging modalities are confronted with problems in the staging of lung cancer, in the evaluation of treatment response, and in establishing whether a residual mass is due to fibrosis, residual tumors or local recurrence. Nuclear medicine imaging techniques have advanced from planar gallium-67 citrate scans in the 1970s to multihead-detector single-photon emission tomography for 67Ga, Thallium-201 chloride, technetium-99m SestaMIBI, monoclonal antibodies, and octreotide compounds. Results of positron emission tomography (PET) with fluorine-18 deoxyglucose or carbon-11 methionine are very promising. PET units are now employed in centers all over the world and the recently introduced whole-body PET units will be ideal for the correct staging of malignant diseases. The current status of various nuclear medicine imaging procedures is reviewed. The problems and advantages of each scintigraphic procedure are discussed. It appears that many of the problems that confront morphological imaging will be solved by nuclear medicine techniques in the future.

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Section: Value For Detection Of Mediastinal Involvementmentioning

confidence: 97%

Section: Relationship Between 67ga Uptake and Histological Typementioning

confidence: 99%

Tracer imaging in lung cancer

et al. 1994

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“…Insgesamt folgern wir, daß die Bestimmung der 6 7 Ga-Kinetik im Blut wenig klinisch relevante Informationen über Vorhandensein, Größe und Wachstumsrate von malignen Tumoren beim Menschen liefert. 6 7 Gallium is widely used for tumor imaging (6,10,13,16,23), but clinical reliability is limited to specific indications (1,11,15,21). Knowledge about gallium kinetics in man is still incomplete.…”

Section: Die 67 Ga-kinetik Im Blut Bei Patienten Mit Malignen Tumorenunclassified

67Gallium Kinetics in the Blood of Patients with Malignant Tumors

Keller¹,

Mk²,

Koeppe³

1983

Nuklearmedizin

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67GaIlium was injected into 60 patients with malignant tumors and into 42 patients in whom malignant tumors had been excluded by clinical investigation. 67Ga kinetics in blood were evaluated by non-linear least square regression computer analysis according to an open 2-compartment model where elimination proceeds from the peripheral compartment. Parameters of 67Ga kinetics in tumor patients showed a bimodal distribution, as was also the case in patients without tumors. No difference could be demonstrated between kinetic parameters of tumor patients and patients without tumors. In 4 patients, 67Ga kinetics could be evaluated before and after treatment of their malignant tumors, but a decrease in the volume of distribution was the single alteration of kinetic parameters occurring after treatment. This decrease may be explained by a smaller peripheral compartment resulting from the loss of tumor mass after treatment. Nevertheless, we conclude that the evaluation of 67Ga kinetics in blood will provide only limited information about the presence, size and growth rate of malignant tumors in man.

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Sensitivity of chest radiography, computed tomography, and gallium scanning to metastasis of lung carcinoma

Friedman

Feigin

Liston

et al. 1984

Cancer

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To determine the efficacy of radiologic techniques in preoperative staging of the mediastinum for lung carcinoma, the authors studied 45 patients with chest films supplemented with oblique views, esophagrams, gallium scans, and computed tomograms (CT). They interpreted the studies and correlated surgical findings using a modified classification of lymph node regions. The mediastinum was positive on chest films in 14 of the 21 cases with pathologically proved mediastinal metastases (33% false‐negative). Gallium scans in cases with a positive primary were positive in 12 of 15 cases with mediastinal or hilar metastases (20% false‐negative). Computed tomography showed nodes over 1 or 1.5 cm in size in or adjacent to the biopsy‐positive node region in 18 of 19 patients (5% false‐negative), extranodal mediastinal involvement, and 9 of 10 proven hilar metastases. Computed tomography is a sensitive screening technique in patients who would otherwise require an invasive staging procedure, but is not highly specific (false‐positive rate 38%).

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Noninvasive evaluation of mediastinal metastases in bronchogenic carcinoma: A prospective comparison of chest radiography and gallium-67 scanning

Cited by 28 publications

References 24 publications

Tracer imaging in lung cancer

Tracer imaging in lung cancer

67Gallium Kinetics in the Blood of Patients with Malignant Tumors

Sensitivity of chest radiography, computed tomography, and gallium scanning to metastasis of lung carcinoma

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