Noninvasive evaluation of muscle mass by ultrasonography of quadriceps femoris muscle in End-Stage Renal Disease patients on hemodialysis

Sabatino, Alice; Regolisti, Giuseppe; Delsante, Marco; Motta, Tommaso Di; Cantarelli, Chiara; Pioli, Sarah; Grassi, G; Batini, Valentina; Gregorini, Mariacristina; Fiaccadori, Enrico

doi:10.1016/j.clnu.2018.05.004

Cited by 64 publications

(66 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[17][18][19] In CKD populations, ultrasound has recently been used to identify the presence of low muscle mass, measured as quadriceps thickness, in end stage renal disease patients receiving haemodialysis. 20 We have shown that ultrasound-derived RF-CSA is associated with physical performance amongst patients with CKD stages 3b-5 not requiring dialysis. 21 The utility of ultrasound to detect changes in muscle mass in response to an intervention in CKD populations, in comparison with a gold standard (i.e.…”

Section: Introductionmentioning

confidence: 81%

“…In CKD populations, ultrasound has recently been used to identify the presence of low muscle mass, measured as quadriceps thickness, in end stage renal disease patients receiving haemodialysis . We have shown that ultrasound‐derived RF‐CSA is associated with physical performance amongst patients with CKD stages 3b–5 not requiring dialysis .…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

Ultrasound assessment of muscle mass in response to exercise training in chronic kidney disease: a comparison with MRI

Gould

Watson

Wilkinson

et al. 2019

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

Background Chronic kidney disease (CKD) is a catabolic condition associated with muscle wasting and dysfunction, which associates with morbidity and mortality. There is a need for simple techniques capable of monitoring changes in muscle size with disease progression and in response to interventions aiming to increase muscle mass and function. Ultrasound is one such technique; however, it is unknown how well changes in muscle cross‐sectional area (CSA) measured using ultrasound relate to changes in whole muscle volume measured using magnetic resonance imaging. We tested whether rectus femoris CSA (RF‐CSA) could be used as a valid indication of changes in quadriceps muscle volume as a single measure of muscle size and following a 12 week exercise intervention that resulted in muscle hypertrophy. Methods Secondary analysis of data was collected from the ExTra CKD study (ISRCTN 36489137). Quadriceps muscle size was assessed from 36 patients with non‐dialysis CKD before and after 12 weeks of supervised exercise that resulted in muscle hypertrophy. Results Strong positive correlations were observed between RF‐CSA and quadriceps volume at baseline ( r 2 = 0.815, CI 0.661 to 0.903; P < 0.001) and following 12 week exercise ( r 2 = 0.845, CI 0.700 to 0.923; P < 0.001). A moderate positive association was also observed between changes in RF‐CSA and quadriceps following exercise training (rho = 0.441, CI 0.085 to 0.697; P = 0.015). Bland–Altman analysis revealed a small bias (bias 0.6% ± 12.5) between the mean percentage changes in RF‐CSA and quadriceps volume but wide limits of agreement from −24 to 25. Conclusions Rectus femoris CSA appears to be a reliable index of total quadriceps volume as a simple measure of muscle size, both as a single observation and in response to exercise training in non‐dialysis CKD patients.

show abstract

Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 89%

Ultrasound assessment of muscle mass in response to exercise training in chronic kidney disease: a comparison with MRI

Gould

Watson

Wilkinson

et al. 2019

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

show abstract

“…Mass. Assessment of nutritional status and especially evaluation of muscle mass is essential for the identification of patients at risk for the development of PEW [44]. Indirect measures of muscle mass such as serum creatinine (before a HD treatment), creatinine appearance, creatinine generation rate (%CGR), and creatinine index have been proposed.…”

Section: Nt-probnp and Musclementioning

confidence: 99%

N-terminal Pro-B-Type Natriuretic Peptide and Malnutrition in Patients on Hemodialysis

Larifla

Merault²,

Galantine³

et al. 2020

International Journal of Nephrology

View full text Add to dashboard Cite

Natriuretic peptides, brain natriuretic peptide (BNP), and N-terminal probrain natriuretic peptide (NT-proBNP) are mainly known as diagnostic markers for heart failure with high diagnostic and prognostic values in the general population. In patients who are undergoing hemodialysis (HD), changes in NT-proBNP can be related to noncardiac problems such as fluid overload, inflammation, or malnutrition and can also be influenced by the dialysis characteristics. The current review aimed to summarize findings from studies on the association between NT-proBNP and malnutrition in HD patients. Articles published after 2009 and over a ten-year period were considered for inclusion. We first briefly discuss the traditional functions of NT-proBNP, and after, we describe the functions of this prohormone by focusing on its relation with protein energy wasting (PEW) in HD patients. Mechanisms that could explain these relationships were also discussed. Overall, 7 studies in which the investigation of the relations between NT-proBNP and nutritional status in HD patients were among the main objects were taken into account. NT-proBNP levels correlated with several factors described in the 4 categories of markers indicative of PEW (body mass and composition, muscle mass, biochemical criteria, and dietary intakes) and/or were associated with PEW. Interactions between several parameters could be involved in the association between NT-proBNP and malnutrition with a strong role of weight status. NT-proBNP is elevated in HD patients and is associated with malnutrition. Nevertheless, the prognostic value of NT-proBNP on nutritional status should be evaluated.

show abstract

“…In addition, muscle US measurements have shown good correlations with gold standard imaging methods (CT, MRI, DEXA) in different clinical settings, such as in patients with chronic obstructive pulmonary disease (COPD), in cardiac patients and in critically ill patients without AKI . Very recent data suggest that muscle US could be sensitive enough to identify hemodialysis patients with reduced muscle mass, as compared with healthy subjects, age‐matched sedentary hospitalized patients with normal renal function and well‐nourished ESRD patients on hemodialysis . More studies are needed to validate the application of the US techniques for the assessment of muscle mass in hemodialysis patients.…”

Section: Protein Energy Wasting and Nutritional Status Evaluation In mentioning

confidence: 99%

“…[24][25][26] Very recent data suggest that muscle US could be sensitive enough to identify hemodialysis patients with reduced muscle mass, as compared with healthy subjects, age-matched sedentary hospitalized patients with normal renal function and well-nourished ESRD patients on hemodialysis. 27 More studies are needed to validate the application of the US techniques for the assessment of muscle mass in hemodialysis patients.…”

Section: Nutritional Status Evaluation In Esrdmentioning

confidence: 99%

Dietary protein and nutritional supplements in conventional hemodialysis

Sabatino

Piotti

Cosola

et al. 2018

Seminars in Dialysis

Self Cite

View full text Add to dashboard Cite

Protein energy wasting (PEW) is a condition commonly occurring among patients with ESRD on hemodialysis. PEW is characterized by depletion of protein and energy stores and is caused by multiple factors related to chronic kidney disease, acute and chronic comorbidities and by renal replacement therapy itself. Anorexia is central in the pathogenesis of PEW; it is frequently observed in these patients whose protein and energy intakes are typically lower than guidelines recommendations. If untreated, PEW invariably leads to major complications, and may activate a vicious circle with further worsening of nutritional status. Dietary counseling and nutritional status monitoring play a key role in the prevention and treatment of PEW, since they allow an early identification of high risk patients, as well as the assessment of the response to nutritional intervention. Different nutritional approaches can be implemented following thorough nutritional counseling. These are chosen on the basis of patients' spontaneous dietary intake, severity of PEW and acute comorbidities. Initially, regular encounters with the dietitian allow patients to clarify doubts and strengthen basic concepts on nutrition to improve dietary intake and prevent PEW. When PEW is present or the patient is at high risk, the clinician may opt for the administration of oral intradialytic or daily supplements, aiming at increasing energy and protein intake, while in selected cases intradialytic parenteral nutrition may be used. This review addresses the main issues of nutritional status in ESRD patients on hemodialysis-its evaluation and monitoring, as well as at describing the available nutritional interventions.

show abstract

Noninvasive evaluation of muscle mass by ultrasonography of quadriceps femoris muscle in End-Stage Renal Disease patients on hemodialysis

Cited by 64 publications

References 23 publications

Ultrasound assessment of muscle mass in response to exercise training in chronic kidney disease: a comparison with MRI

Ultrasound assessment of muscle mass in response to exercise training in chronic kidney disease: a comparison with MRI

N-terminal Pro-B-Type Natriuretic Peptide and Malnutrition in Patients on Hemodialysis

Dietary protein and nutritional supplements in conventional hemodialysis

Contact Info

Product

Resources

About