Noninvasive Hemodynamic Profiles during Hemodialysis in Patients with and without Heart Failure

Abstract

Background: Although the dynamics of blood pressure (BP) during dialysis provide information related to the control system, the prognosis and relationships between temporal changes in intradialytic hemodynamic regulation, BP, and decreased cardiac function remain largely unclear. Methods: Hemodynamic parameters, including heart rate (HR), stroke volume (SV), cardiac index, and systemic vascular resistance index, were recorded using a noninvasive hemodynamic device on a beat-by-beat basis in 40 patients on dialysis who were divided into three groups, i.e., those with and without BP lability and those with heart failure (HF). Statistical measurements, including mean, standard deviation, coefficient of variation (CV), and index of nonrandomness of each hemodynamic parameter were derived from the three different phases divided equally during dialysis and compared using 3×3 two-way mixed-model analysis of variance to determine the effects of the different stages of hemodialysis (HD), cardiac function, and intradialytic changes in BP on the hemodynamic parameters. In addition, multivariate Cox regression was performed to determine the association between the changes in the derived parameters and BP lability. Results: The average SV tended to decrease during HD in all groups (p = 0.041). A significant decrease was observed in the CV of SV between the first two stages of HD in patients with labile BP and HF when compared to those without labile BP (p = 0.037). Significant interactions between group and stage of the index of nonrandomness for HR were also noted; this index was significantly higher in patients without labile BP than in those with labile BP or HF (p = 0.048). A higher difference between the early and middle stages of HD for nonrandomness indexes of HR was an independent predictor of reduced BP lability during HD (HR = 0.844, 95% confidence interval 0.722-0.987, p = 0.034). Conclusions: Increases in the CV of SV and the index of nonrandomness for HR during earlystage HD in response to decreased SV may be associated with better BP control during HD. This finding suggests that patients with more structurally meaningful hemodynamic control have a more favorable cardiovascular outcome.

Cardiac Output Changes during Renal Replacement Therapy: A Scoping Review

“…Out of the 28 studies in which UF volume or UF rate were reported, we identified 23 studies, for a total of 43 cohorts which investigated the correlation between the biggest CO changes and UF rate [27, 28, 30, 34, 36, 40, 45, 48, 49, 51‒64]. We found a weak correlation between the change in CO and the UF rate ( r = 0.3, p = 0.05) (shown in Fig.…”

Urgent Implantation of Peritoneal Dialysis Catheter in Chronic Kidney Disease and Acute Kidney Injury—A Review

“…Figure 2 illustrates the geographical distribution of USPD usage. The timing of KRT initiation in AKI is vital, as any delay may lead to a poorer prognosis for the patient [80,81].…”

“…Moreover, peritoneal dialysis was also considered hemodynamically stable in contrast to hemodialysis; thus, it was more commonly used in hemodynamically unstable patients [42,76,81].…”