Noninvasive Imaging Surrogate of Angiogenesis in Osteosarcoma

Abstract

This study suggests an important role of DCE-MRI as a noninvasive imaging surrogate of tumor angiogenesis in osteosarcoma based on visual inspection of TIC.

Standardized Index of Shape (SIS): a quantitative DCE-MRI parameter to discriminate responders by non-responders after neoadjuvant therapy in LARC

“…No precautions were taken to avoid bowel movements, nor was the administration of butylscopolamine, dicyclomine, glucagon or similar drugs carried out, because a volumetric analysis was performed thus minimizing errors due to caused voxel misalignments. The semi-quantitative approach used takes inspiration from studies on breast and osteosarcoma tumours, where leaky capillaries associated with tumour neovascularization determine rapid gadolinium tissue uptake and early washout, which correlate with VEGF and MVD [10][11][12]. However, being rapid growing, colorectal carcinomas similar to breast tumour and most malignant tumours for their biological characteristics, using their contrast kinetics on MRI can be depicted by DCE-MRI [8][9][10][11].…”

“…The circumferential resection margin was examined by sampling a 1-mm thick slice [22] and was defined as positive if the tumour residuals were found ≤1 mm from the margin. Lymph nodes were examined by the manual dissection method [11]. The mandard TRG scoring system was used [23]: TRG 1 means a complete response with absence of residual cancer and fibrosis extending through the wall.…”

“…Studies are therefore focusing on the potential added benefit of functional and/or quantitative methods of MR image evaluation. Dynamic contrast-enhanced MRI (DCE-MRI) has proven useful in detecting residual tumour after CRT [5][6][7][8][9]: leaky capillaries associated with tumour neovascularization determine a rapid gadolinium uptake and an early wash-out, which correlate with the vascular endothelial growth factor (VEGF) expression and micro vessel density (MVD) [10][11][12]. DCE-MRI evaluation can be assessed through time intensity curve (TIC) analysis performed using three different approaches: qualitative DCE-MRI, quantitative DCE-MRI and semiquantitative DCE-MRI based on pattern analysis.…”

Musculoskeletal Tumors: How to Use Anatomic, Functional, and Metabolic MR Techniques

“…Perfusion imaging sequences are used for providing insight into the vascularity of a tumor and can be accomplished with a variety of pulse sequences, including DW sequences (31), unenhanced perfusion sequences (60,61), and the most commonly implemented dynamic contrastenhanced sequence (62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79)(80). Perfusion imaging with dynamic contrast-enhanced MR imaging is the most popular technique at this time, since other techniques have not been well explored for musculoskeletal tumors.…”

Clinical applications of positron emission tomography-computed tomography in oncology

“…FDG-PET and PET-CT may play an important role in determining the metabolic rates of osteosarcoma, guiding biopsy, detecting local recurrence in amputation stumps, evaluating patients with suspected metastatic disease, monitoring response to therapy and assessing for prognosis and differentiating viable sarcoma from post treatment changes. [77,78] FDG uptake in osteosarcoma has a good correlation with histological grading or tumor aggressiveness. Bastiaannet and coworkers conducted a meta-analysis of 29 clinical studies on the diagnostic value of FDG-PET in the detection, grading, and therapy response of soft tissue and bone sarcomas.…”