Noninvasive Imaging, Treatment, and Microscopic Confirmation of Clearance of Basal Cell Carcinoma

Goldgeier, Mark H.; Alessi‐Fox, Christi; Zavislan, James M.; Harris, D P; González, Salvador

doi:10.1046/j.1524-4725.2003.29050.x

Cited by 46 publications

(26 citation statements)

References 14 publications

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“…Its mode of action implies the induction of the innate immunity resulting in a selective antitumoral immune response through the activation of dendritic cells, cytotoxic T lymphocytes and proinflammatory cytokines. RCM has been used for monitoring and evaluation of treatment efficacy of basal cell carcinoma and lentigo maligna melanoma during topical IMIQ therapy [36,37,38]. To our knowledge, no systematic RCM evaluation of treatment response of AK to IMIQ has been performed.…”

Section: Discussionmentioning

confidence: 99%

Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

et al. 2009

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Background: Actinic keratoses (AK) represent cutaneous carcinoma in situ and have previously been evaluated by reflectance confocal microscopy (RCM). Treatment of AK with imiquimod (IMIQ) 5% cream has been shown to ‘highlight’ subclinical lesions. Objective: The aim of this study was to test the applicability of RCM for noninvasive monitoring of actinic field cancerization and detection of subclinical AK. Subjects and Methods: AK and surrounding skin sites with no apparent AK of 11 volunteers were selected for imaging and subsequently classified as ‘clinical’ and ‘subclinical’ AK. IMIQ was used 3 times weekly for 4 weeks. Results: RCM was able to detect morphologic features of AK in both clinical and subclinical AK; features were more pronounced in clinical lesions. The immunomodulatory response induced by IMIQ was visualized by RCM. Conclusion: Our findings indicate that RCM allows noninvasive monitoring of treatment response in vivo and permits early detection of subclinical AK, thus substantiating the incentive for therapy.

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Section: Discussionmentioning

confidence: 99%

Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

et al. 2009

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“…They found that the confocal features correlate well with the stained section of a biopsy. Furthermore, BCC-patients were treated with a topical immune response modifier; the presence, as well as the clearance of the BCC was analyzed by reflectance microscopic measurements [40,41]. Another study looks at the ability for accurate differentiation of actinic keratoses (AK) vs. SCC, reaching the conclusion that the reflectance LSM is currently restricted because of the limited depth visualization [42].…”

Section: Application Of Laser Scanning Microscopy In Diagnoses and Thmentioning

confidence: 99%

Application of laser spectroscopic methods for in vivo diagnostics in dermatology

Meyer¹,

Lademann²

2007

Laser Phys. Lett.

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Abstract:The importance of dermatologic non-invasive imaging techniques has increased over the last decades. Technological advancements have led to the development of various scanning tools, enabling in vivo examination of living human skin. All provide a preservation of the tissue's physical structure whilst being studied in its native state. Different modalities are currently being used to investigate the skin tissue. Although many of these scanning instruments are still undergoing research, promising imaging techniques, such as high-resolution ultrasonography, optical coherence tomography, magnetic resonance imaging and spectroscopic methods, may yet find a role in dermatologic diagnosis and disease monitoring. In this article, the authors demonstrate their own results and review the influence of laser spectroscopic methods as non-invasive diagnostic tools in dermatology. µmFluorescence image obtained 5 min after application of a dye

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“…2 If there is clinical evidence of persistent tumor at this assessment, a biopsy or other alternative intervention should be considered. 2 Case reports, open-label, and phases II and III clinical trials have demonstrated the efficacy and safety of imiquimod in the treatment of sBCC (Table II) [37][38][39][40][41][42][43][44][45] with cure rates ranging from 43% to 100%. 37-39-43-45 Complete response has been reported in as little as 6 weeks but may take as long as 18 weeks [42][43] (Table II).…”

Section: Supercial Basal Cell Carcinoma (Sbcc)mentioning

confidence: 99%

Viral and Nonviral Uses of Imiquimod: A Review

2004

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Noninvasive Imaging, Treatment, and Microscopic Confirmation of Clearance of Basal Cell Carcinoma

Abstract: The ability to use CM to image in real time without discomfort to the patient makes it a powerful tool to assist in the diagnosis of skin disease.

Cited by 46 publications

References 14 publications

Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

Application of laser spectroscopic methods for in vivo diagnostics in dermatology

Viral and Nonviral Uses of Imiquimod: A Review

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