Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs

Zanghi, Brian M.; Cupp, Carolyn J.; Pan, Yuanlong; Tissot-Favre, Delphine G.; Milgram, Norton W.; Nagy, Tim R.; Dobson, Howard

doi:10.2460/ajvr.74.5.733

Cited by 18 publications

(11 citation statements)

References 30 publications

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“…8,[17][18][19][20] However, several studies also showed that QMR underestimated FM when using deuterium dilution and a fourcomponent model as the gold standard. [21][22][23][24][25][26] Values for both FM and FFM, while significantly different from CCA values, were still significantly correlated for each body compartment measure. For FFM, residual bias increased significantly with increasing CCA mass, while residual bias did not occur for FM.…”

Section: Discussionmentioning

confidence: 81%

In VivoDetermination of Body Composition in Zebrafish (Danio rerio) by Quantitative Magnetic Resonance

et al. 2016

Zebrafish

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Zebrafish (Danio rerio) as a model research organism continues to expand its relevance and role in multiple research disciplines, with recent work directed toward models of metabolism, nutrition, and energetics. Multiple technologies exist to assess body composition in animal research models at various levels of detail (tissues/ organs, body regions, and whole organism). The development and/or validation of body composition assessment tools can open new areas of research questions for a given organism. Using fish from a comparative nutrition study, quantitative magnetic resonance (QMR) assessment of whole body fat and fat-free mass (FFM) in live fish was performed. QMR measures from two cohorts (n = 26 and n = 27) were compared with chemical carcass analysis (CCA) of FM and FFM. QMR was significantly correlated with chemical carcass values (fat, p < 0.001; lean, p = 0.002), although QMR significantly overestimated fat mass (FM) (0.011 g; p < 0.0001) and underestimated FFM (-0.024 g; p < 0.0001) relative to CCA. In a separate cross-validation group of fish, prediction equations corrected carcass values for FM ( p = 0.121) and FFM ( p = 0.753). These results support the utilization of QMR-a nonlethal nondestructive method-for cross-sectional or longitudinal body composition assessment outcomes in zebrafish.

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Section: Discussionmentioning

confidence: 81%

In VivoDetermination of Body Composition in Zebrafish (Danio rerio) by Quantitative Magnetic Resonance

et al. 2016

Zebrafish

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“…However, the deuterium dilution technique is a lengthy and costly process that requires animals to be anesthetized, the collection of several blood samples, and expensive equipment that is rarely found in general veterinary practices, which makes it impractical in most situations. Isotopic dilution is most useful for validation of alternative techniques for evaluation of body composition, such as DEXA 13,14 or quantitative MRI. 14 A 9-point scale has been proposed for assessment of the body condition of dogs that involves observation and palpation of the animal to evaluate the percentage of body fat.…”

Section: Bcsmentioning

confidence: 99%

Indirect prediction of total body water content in healthy adult Beagles by single-frequency bioelectrical impedance analysis

Yaguiyan-Colliard¹,

Daumas²,

Bousbiat³

et al. 2015

ajvr

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“…In the dogs, we were unable to obtain information regarding the volume of the adipose tissues. However, the body fat mass of beagle dogs, which includes not only the adipose tissues but also the lipid content in blood and other tissues, has been reported and the body fat percentage could be calculated as about 17-20 % [11]. Therefore, we assumed that 15 % of the body weight was related to the adipose tissue volume in dogs.…”

Section: Discussionmentioning

confidence: 99%

Disposition of the Highly Fat Distributed Compound 1-(4-Methoxyphenyl)-4-(2,2,4,6,7-Pentamethyl -2,3-Dihydro-1-Benzofuran-5-yl)Piperazine (TAK-357) in Rats and Dogs

et al. 2016

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The non-clinical pharmacokinetics (PK) of TAK-357, a highly lipophilic (clogP>6) potential agent for the amelioration of Alzheimer's disease, was investigated in rats and dogs. A long half-life (t) in plasma was observed in animals and a low total body clearance with high distribution volume was consistent with the long t. The absorption, distribution, metabolism and excretion (ADME) studies using radiolabeled TAK-357 revealed that the total radioactivity was highly distributed to the adipose tissues and sustained with high concentration for over 4 weeks after oral administration. The metabolite analysis also revealed that the main component in the plasma and adipose tissues was unchanged TAK-357. The major elimination route of absorbed TAK-357 was suggested to be by metabolism. An ADME study indicated that the adipose tissue is the main depot of remaining TAK-357 in the body and slow release from the adipose tissues contributes to the long t. The PK of highly lipophilic compounds have a tendency to be affected by body weight changes especially changes in the adipose tissues. Therefore, it is considered that the relationship between the plasma levels of TAK-357 and the body weight should be evaluated carefully during the clinical trials.

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Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs

Cited by 18 publications

References 30 publications

In VivoDetermination of Body Composition in Zebrafish (Danio rerio) by Quantitative Magnetic Resonance

In VivoDetermination of Body Composition in Zebrafish (Danio rerio) by Quantitative Magnetic Resonance

Indirect prediction of total body water content in healthy adult Beagles by single-frequency bioelectrical impedance analysis

Disposition of the Highly Fat Distributed Compound 1-(4-Methoxyphenyl)-4-(2,2,4,6,7-Pentamethyl -2,3-Dihydro-1-Benzofuran-5-yl)Piperazine (TAK-357) in Rats and Dogs

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