Noninvasive monitoring of traumatic brain injury and post-traumatic rehabilitation with laser-induced photoacoustic imaging

Yang, Sihua; Xing, Da; Lao, Yeqi; Yang, Diwu; Zeng, Lvming; Xiang, Liangzhong; Chen, Wei R.

doi:10.1063/1.2749185

Cited by 74 publications

(43 citation statements)

References 12 publications

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“…Subsequently, the vasculature of rat brains as well as hemorrhage and physiological changes following drug stimulation or carotid ligation have been imaged noninvasively through endogenous contrast provided by hemoglobin optical absorption spectra, with a spatial resolution of 110 lm and a clinically viable surface fluence. 126,127 In addition, sPA imaging has also been utilized for quantifying hemoglobin oxygen saturation within the rat brain microvasculature. 30 Despite this ability to image brain vasculature via endogenous contrast, the use of exogenous agents is likely to continue as a means of improving contrast and evaluating new contrast agents, as demonstrated by the evaluation of PEGhollow gold nanospheres.…”

Section: Brain Functional Imagingmentioning

confidence: 99%

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

2011

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Photoacoustic imaging is a biomedical imaging modality that provides functional information, and, with the help of exogenous contrast agents, cellular and molecular signatures of tissue. In this article, we review the biomedical applications of photoacoustic imaging assisted with exogenous contrast agents. Dyes, noble metal nanoparticles, and other constructs are contrast agents which absorb strongly in the near-infrared band of the optical spectrum and generate strong photoacoustic response. These contrast agents, which can be specifically targeted to molecules or cells, have been coupled with photoacoustic imaging for preclinical and clinical applications ranging from detection of cancer cells, sentinel lymph nodes, and micrometastasis to angiogenesis to characterization of atherosclerotic plaques. Multi-functional agents have also been developed, which can carry drugs or simultaneously provide contrast in multiple imaging modalities. Furthermore, contrast agents were used to guide and monitor the therapeutic procedures. Overall, photoacoustic imaging shows significant promise in its ability to assist in diagnosis, therapy planning, and monitoring of treatment outcome for cancer, cardiovascular disease, and other pathologies.

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Section: Brain Functional Imagingmentioning

confidence: 99%

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

2011

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“…[5][6][7][8][9] In the past decade, PA imaging has made great progress in biomedical application, such as tumor detection, 10,11 noninvasive monitoring of vasculature networks 12,13 and blood oxygen saturation, 14 brain functional imaging [15][16][17] and identi¯-cation of atherosclerotic plaques. 18 PA e®ect refers to the generation of acoustic wave by the absorption of laser.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Viscoelasticity Imaging of Biological Tissues With Intensity-Modulated Continuous-Wave Laser

Zhao

Yang

2013

J. Innov. Opt. Health Sci.

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In this paper, a novel photoacoustic viscoelasticity imaging (PAVEI) technique that provides viscoelastic information of biological tissues is presented. We deduced the process of photoacoustic (PA) e®ect on the basis of thermal viscoelasticity theory and established the relationship between the PA phase delay and the viscoelasticity for soft solids. By detecting the phase delay of PA signal, the viscoelasticity distribution of absorbers can be mapped. Gelatin phantoms with di®erent densities and di®erent absorption coe±cients were used to verify the dependence of PAVEI measurements. Moreover, tissue mimicking phantoms mixed with fat and collagen at di®erent concentrations were used to testify the feasibility of this technique with reliable contrast. Finally, the PAVEI was successfully applied to discrimination between biological tissue constituents. Our experimental results demonstrate that this novel technique has the potential for visualizing the anatomical and biomechanical properties of biological tissues.

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“…By combining optical imaging with ultrasound, PA imaging can achieve both high contrast and high spatial resolution. PA imaging has been used for both structural and functional imaging of tumor, 5 brain cortex perfusion, 6,7 microvascular structure, 8 and hemoglobin concentration and oxygenation, 9 as well as for lymph flow cytometry. 10 Furthermore, it shows potential for blood flow measurement.…”

Section: Introductionmentioning

confidence: 99%

Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo

Yao

Maslov

et al. 2009

J. Biomed. Opt.

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Abstract. Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells ͑RBCs͒ as an endogenic contrast agent. However, intermittent RBC flow in capillaries results in discontinuous and fragmentary capillary images. To overcome this problem, we use Evans blue ͑EB͒ dye as a contrast agent for in vivo photoacoustic imaging. EB has strong optical absorption and distributes uniformly in the blood stream by chemically binding to albumin. With the help of EB, complete and continuous microvascular networks-especially capillaries-are imaged. The diffusion dynamics of EB leaving the blood stream and the clearance dynamics of the EB-albumin complex are also quantitatively investigated.

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Noninvasive monitoring of traumatic brain injury and post-traumatic rehabilitation with laser-induced photoacoustic imaging

Cited by 74 publications

References 12 publications

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

Photoacoustic Viscoelasticity Imaging of Biological Tissues With Intensity-Modulated Continuous-Wave Laser

Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo

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