Noninvasive, Objective, Multimodal Tear Dynamics Evaluation of 5 Over-the-Counter Tear Drops in a Randomized Controlled Trial

Abstract

Noninvasive multimodal imaging has the potential to evaluate tear dynamics and the efficacy of artificial tears objectively. Certain artificial tear components and the temporary increase in tear volume after instillation of artificial tears may contribute to transient reduction of visual quality.

Evaluation of Tear Meniscus Dynamics Using Anterior Segment Swept-Source Optical Coherence Tomography After Topical Solution Instillation for Dry Eye

“…In patients with dry eye, tear meniscus measurements obtained after the instillation of CMC took longer to return to the baseline levels compared with those in normal subjects. 27 Moreover, Yuan et al 32 reported that patients with aqueous tear-deficient dry eye had decreased tear meniscus dynamics during normal and delayed blinking. The effects of instillation of ophthalmic solutions would be different between patients with and without dry eye because of differences in the baseline levels, tear clearance rate, and blinking.…”

Effect of Rebamipide Ophthalmic Suspension on Optical Quality in the Short Break-up Time Type of Dry Eye

“…[22][23][24][25][26] Ridder et al 26 investigated both the short-term effect and long-term daily use of artificial tears for up to 2 weeks and reported that the long-term effect resulted in less of a short-term effect in patients with dry eye. However, the therapeutic effect of eye drops specifically prescribed for dry eye on the optical quality has not been reported previously.…”

Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous‐deficient dry eye

“…We previously investigated the short‐term effects of five different over‐the‐counter tear drops on optical quality and found that the effect varies depending on the composition of artificial tears and the severity of dry eye (Tung et al. ). Differences in dry eye diagnostic criteria and methodology among studies may have also contributed to the difference including the results of the present study.…”

“…Tung et al. () reported that instillation of a certain type of artificial tear (polyethylene glycol drops) worsened visual quality along with an increase in tear meniscus dimensions in patients with aqueous‐deficient dry eye. According to previous animal studies, diquafosol increases the tear meniscus dimension 15 min after instillation in normal cats (Murakami et al.…”