2018
DOI: 10.1002/lsm.22786
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Noninvasive optical spectroscopy for identification of non‐melanoma skin cancer: Pilot study

Abstract: This pilot trial utilizes optical spectroscopy as a noninvasive method for determining cutaneous lesion histology. Effect sizes observed across optical parameters for benign and malignant tissue types will guide larger prospective studies that may ultimately lead to prediction of lesional histology without need for invasive biopsy. Lasers Surg. Med. 50:246-252, 2018. © 2018 Wiley Periodicals, Inc.

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Cited by 12 publications
(16 citation statements)
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“…In the literature, data concerning the use of NIRS in AK are still lacking, besides a few studies that have previously investigated its vascularization. Carpenter et al [ 19 ] have recently evaluated various cutaneous lesions through the use of optical spectroscopy that permits the measurement of different parameters, including the HHb and O 2 Hb concentration and saturation. Their study aimed to identify the benign or malignant nature of a cutaneous lesion through such techniques and to establish a concordance between spectroscopy and biopsy.…”
Section: Introductionmentioning
confidence: 99%
“…In the literature, data concerning the use of NIRS in AK are still lacking, besides a few studies that have previously investigated its vascularization. Carpenter et al [ 19 ] have recently evaluated various cutaneous lesions through the use of optical spectroscopy that permits the measurement of different parameters, including the HHb and O 2 Hb concentration and saturation. Their study aimed to identify the benign or malignant nature of a cutaneous lesion through such techniques and to establish a concordance between spectroscopy and biopsy.…”
Section: Introductionmentioning
confidence: 99%
“…Likewise, scattering is used to determine physiological processes such as hemodynamics, 14 microcirculation 15 and helps determine tissue morphological characteristics like scatterer size and density 16,17 . Skin DRS spectra reflecting the contents from chromophores such as melanin, bilirubin, and oxy‐deoxyhemoglobin could reveal many diseased conditions like skin inflammation, 18–20 jaundice, 21 vitiligo, 22 melanoma 23 , etc. A typical DRS instrumentation consists of a light source, spectrometer, fibre optic probe for transmitting, and collection of light 24 .…”
Section: Introductionmentioning
confidence: 99%
“…Diffuse reflectance spectroscopy as a sub‐group of spectroscopic methods is a non‐invasive real‐time technology for characterizing biological tissue and samples. The sample is illuminated with visible near‐infrared (NIR) light and the optical features of the tissue can be described on the basis of its absorption and scattering properties .…”
Section: Introductionmentioning
confidence: 99%
“…Qualitative and quantitative technologies such as phase contrast microscopy, infrared surface plasmon, and differential interference microscopy have been introduced for the determination of the refractive index of cells . These systems allow spatial distribution imaging of refractive indices ; however, it is difficult to extract analytical data and there are some limitations in these imaging technologies due to optical artifacts and reduced imaging resolution in which technical developments for correcting these limitations make them expensive. Instead, diffuse reflectance spectroscopy considered to be more easy‐to‐use optical technology .…”
Section: Introductionmentioning
confidence: 99%
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