Noninvasive PET tracking of post-transplant gut microbiota in living mice

Wang, Yiguang; Zhang, Chenran; Lai, Jianhao; Zhao, Yanping; Lu, Dehua; Bao, Rui; Feng, Xun; Zhang, Ting; Liu, Zhaofei

doi:10.1007/s00259-019-04639-3

Cited by 15 publications

(21 citation statements)

References 31 publications

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“…Previously, metabolic oligosaccharide engineering and biorthogonal click chemistry were used to label commensal bacteria in the gut and demonstrated the distribution and colonization of labeled bacteria in vivo by two‐photon microscopy and non‐invasive whole‐body imaging (Geva‐Zatorsky et al, 2015 ). Radiolabeled probes ( 18 F‐FDS and 64 Cu‐NOTA‐DBCO) could also achieve in vivo imaging of gut microbiota by using PET/CT (Y. Wang et al, 2020 ; Z. Zhang et al, 2021 ). Meanwhile, the developed microscopy techniques, such as two‐photon microscopy, multiphoton microscopy and allows to observe the activity of microglia in the living brain (Hierro‐Bujalance et al, 2018 ; Zhao et al, 2018 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

Microbiota‐microglia connections in age‐related cognition decline

et al. 2022

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Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging‐induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut‐brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age‐related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age‐related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota‐microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).

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Section: Future Perspectivesmentioning

confidence: 99%

Microbiota‐microglia connections in age‐related cognition decline

et al. 2022

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“…Subsequent derivatization of the tags, often with the aid of click chemistry, allows further detection by different instrumentation. This strategy has been used to fluorescently label specific pathogenic bacteria, a particular subgroup of gut bacteria or the entire commensal microbiota, to track their colonization or dissemination in the host intestinal tract. ,,,, Based on the substrate or precursor used, this labeling strategy can be categorized into the following types.…”

Section: Metabolic Labeling Probesmentioning

confidence: 99%

Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut

Lin

Song

et al. 2021

Acc. Chem. Res.

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“…This unique dual-mode imaging probe can be used for preoperative evaluation and real-time intraoperative optical navigation to achieve the maximum degree of safe resection of liver cancer tumors. Wang et al (2020) reported a case of PET and optical imaging using 64 Cu-NOTA-DBCO-labeled Bacteroides fragilis to monitor whether bacterial transplantation improved immune checkpoint inhibition. The direct labeling of bacteria F I G U R E 4 Different types of AIE dots (Reprinted with permission from S. Chen, Wang, et al (2016 with radionuclides enables the noninvasive PET tracking of bacteria in living mice.…”

Section: Other Novel Fluorescent Npsmentioning

confidence: 99%

“…Wang et al (2020) reported a case of PET and optical imaging using 64 Cu‐NOTA‐DBCO‐labeled Bacteroides fragilis to monitor whether bacterial transplantation improved immune checkpoint inhibition. The direct labeling of bacteria with radionuclides enables the noninvasive PET tracking of bacteria in living mice.…”

Section: Nanoprobes For Optical Imagingmentioning

confidence: 99%

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Update on the development of molecular imaging and nanomedicine in China: Optical imaging

Zou

Wang

et al. 2020

WIREs Nanomed Nanobiotechnol

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Molecular imaging has received increased attention worldwide, including in China, because it offers noninvasive characterization of widely diverse clinically significant pathologies. To achieve these goals, nanomedicine has evolved into a broad interdisciplinary field with flexible designs to accommodate and concentrate imaging and therapeutic payloads into pathological cells through selective binding to disease specific cell membrane biomarkers. This concept of personalized medicine reflects the vision of “magic bullets” proposed by German biochemist Paul Ehrlich over 100 years ago. As happening worldwide, Chinese scientists are contributing to this tsunami of science and technologies through impactful national programs and international research collaborations. This review provides a comprehensive update of Chinese innovations to address intractable unmet medical need in China and worldwide in the optical sciences. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging

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Noninvasive PET tracking of post-transplant gut microbiota in living mice

Cited by 15 publications

References 31 publications

Microbiota‐microglia connections in age‐related cognition decline

Microbiota‐microglia connections in age‐related cognition decline

Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut

Update on the development of molecular imaging and nanomedicine in China: Optical imaging

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