Noninvasive quantitative analysis of ceramide in skin of healthy Chinese population

Cheng, Shu-qi; Chang, Yu‐Ling; Fei, W.‐M.; Zhai, Weifang; Cheng, Haiyung; Yang, Sen; Zhang, X.‐J.

doi:10.1111/srt.12457

Cited by 1 publication

(2 citation statements)

References 23 publications

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“…With the subsequent identification of 6-hydroxysphingosine in human epidermal ceramides H has been added to this system to indicate this base [ 12 ]. Some investigators have made the distinction between sphingosine and dihydrosphingosine by using S for the former only and DS for the latter [ 13 – 15 ]. In the original Motta proposal, the stratum corneum ceramides with a base designated as S actually contained a mixture of sphingosine and dihydrosphingosine.…”

Section: Ceramide Structuresmentioning

confidence: 99%

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Lipids and the Permeability and Antimicrobial Barriers of the Skin

Wertz

2018

Journal of Lipids

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The primary purpose of the epidermis of terrestrial vertebrates is to produce the stratum corneum, which serves as the interface between the organism and the environment. As such, the stratum corneum provides a permeability barrier which both limits water loss through the skin and provides a relatively tough permeability barrier. This provides for a degree of resistance to mechanical trauma and prevents or limits penetration of potentially harmful substances from the environment. The stratum corneum consists of an array of keratinized cells embedded in a lipid matrix. It is this intercellular lipid that determines the permeability of the stratum corneum. The main lipids here are ceramides, cholesterol, and fatty acids. In addition, the skin surface of mammals, including humans, is coated by a lipid film produced by sebaceous glands in the dermis and secreted through the follicles. Human sebum consists mainly of squalene, wax monoesters, and triglycerides with small proportions of cholesterol and cholesterol esters. As sebum passes through the follicles, some of the triglycerides are hydrolyzed by bacteria to liberate free fatty acids. Likewise, near the skin surface, where water becomes available, some of the ceramides are acted upon by an epithelial ceramidase to liberate sphingosine, dihydrosphingosine, and 6-hydroxysphingosine. Some of the free fatty acids, specifically lauric acid and sapienic acid, have been shown to have antibacterial, antifungal, and antiviral activity. Also, the long-chain bases have broad spectrum antibacterial activity.

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Section: Ceramide Structuresmentioning

confidence: 99%

“…Similar methodology has been used to examine seasonal variation in ceramides linked to changes in barrier function in acne patients [ 20 ]. This methodology has also been used to examine stratum corneum ceramides in healthy Chinese subjects [ 15 ].…”

Section: Mass Spectrometry and Individual Ceramide Structuresmentioning

confidence: 99%

Lipids and the Permeability and Antimicrobial Barriers of the Skin

Wertz

2018

Journal of Lipids

View full text Add to dashboard Cite

show abstract

Noninvasive quantitative analysis of ceramide in skin of healthy Chinese population

Cited by 1 publication

References 23 publications

Lipids and the Permeability and Antimicrobial Barriers of the Skin

Lipids and the Permeability and Antimicrobial Barriers of the Skin

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