Noninvasive radiation burn diagnosis using speckle phenomenon with a fractal approach to processing

Carvalho, Odile; Benderitter, Marc; Roy, Laurence

doi:10.1117/1.3394261

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…Fractal statistics is being used to study speckle images in many recent studies. 1,12,13 Analyzing the speckle data with fractal statistics provides a measure of the fluctuations of an evolving process at different temporal resolutions. This reveals the self-similarity and regularities which underlie the apparent chaotic changes in the signal.…”

Section: Introductionmentioning

confidence: 99%

Fractality of pulsatile flow in speckle images

Nemati

Kenjereš

Urbach

et al. 2016

Journal of Applied Physics

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The scattering of coherent light from a system with underlying flow can be used to yield essential information about dynamics of the process. In the case of pulsatile flow, there is a rapid change in the properties of the speckle images. This can be studied using the standard laser speckle contrast and also the fractality of images. In this paper, we report the results of experiments performed to study pulsatile flow with speckle images, under different experimental configurations to verify the robustness of the techniques for applications. In order to study flow under various levels of complexity, the measurements were done for three in-vitro phantoms and two in-vivo situations. The pumping mechanisms were varied ranging from mechanical pumps to the human heart for the in vivo case. The speckle images were analyzed using the techniques of fractal dimension and speckle contrast analysis. The results of these techniques for the various experimental scenarios were compared. The fractal dimension is a more sensitive measure to capture the complexity of the signal though it was observed that it is also extremely sensitive to the properties of the scattering medium and cannot recover the signal for thicker diffusers in comparison to speckle contrast. Published by AIP Publishing. [http://dx

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Section: Introductionmentioning

confidence: 99%

Fractality of pulsatile flow in speckle images

Nemati

Kenjereš

Urbach

et al. 2016

Journal of Applied Physics

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“…Laser speckle imaging (LSI) measures laser speckle patterns generated by light scattering in the skin and can detect the perfusion changes. LSI has been applied to diagnose the of radiation skin injury using a pig model, which showed the ability to distinguish the healthy and irradiated skin areas during the clinically latent period 17 . Hyperspectral imaging (HSI) is a wide-field imaging technique which measures spectral changes of reflected light in broad ranges.…”

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confidence: 99%

In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy

Jang

Shim

Wang

et al. 2016

Sci Rep

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Ionizing radiation (IR) injury is tissue damage caused by high energy electromagnetic waves such as X-ray and gamma ray. Diagnosis and treatment of IR injury are difficult due to its characteristics of clinically latent post-irradiation periods and the following successive and unpredictable inflammatory bursts. Skin is one of the many sensitive organs to IR and bears local injury upon exposure. Early-stage diagnosis of IR skin injury is essential in order to maximize treatment efficiency and to prevent the aggravation of IR injury. In this study, early-stage changes of the IR injured skin at the cellular level were characterized in an in vivo mouse model by two-photon microscopy (TPM). Various IR doses were applied to the mouse hind limbs and the injured skin regions were imaged daily for 6 days after IR irradiation. Changes in the morphology and distribution of the epidermal cells and damage of the sebaceous glands were observed before clinical symptoms. These results showed that TPM is sensitive to early-stage changes of IR skin injury and may be useful for its diagnosis.

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“…[130,133,134]. Explanation of the burning mechanism is of the utmost importance, as scalding, flame burns, contact burns and radiation burns, to name a few, have been utilized [135][136][137][138]. A common limitation in these models is a degree of burn depth heterogeneity [139,140], which some investigators go to great lengths to minimize [141].…”

Section: Other Animal Models Of Burn: Hurdles For Incorporating Pain mentioning

confidence: 99%

Progress of clinical practice on the management of burn-associated pain: Lessons from animal models

McIntyre

Clifford

Maani

et al. 2016

Burns

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Opioid-based analgesics provide the mainstay for attenuating burn pain, but they have a myriad of side effects including respiratory depression, nausea, impaired gastrointestinal motility, sedation, dependence, physiologic tolerance, and opioid-induced hyperalgesia. To test and develop novel analgesics, validated burn-relevant animal models of pain are indispensable. Herein we review such animal models, which are mostly limited to rodent models of burn-induced, inflammatory, and neuropathic pain. The latter two are pain syndromes that provide insight into the pain caused by systemic pro-inflammatory cytokines and direct injury to nerves (e.g., after severe burn), respectively. To date, no single animal model optimally mimics the complex pathophysiology and pain that a human burn patient experiences. No currently available burn-pain model examines effects of pharmacological intervention on wound healing. As cornerstones of pain and wound healing, pro-inflammatory mediators may be utilized for insight into both processes. Moreover, common clinical concerns such as systemic inflammatory response syndrome and multiple organ dysfunction remain unaddressed. For development of analgesics, these aberrations can significantly alter the potential efficacy and/or adverse effects of a prescribed analgesic following burn trauma. We therefore suggest that a multi-model strategy would be the most clinically relevant when evaluating novel analgesics for use in burn patients.

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Noninvasive radiation burn diagnosis using speckle phenomenon with a fractal approach to processing

Cited by 8 publications

References 59 publications

Fractality of pulsatile flow in speckle images

Fractality of pulsatile flow in speckle images

In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy

Progress of clinical practice on the management of burn-associated pain: Lessons from animal models

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