Noninvasive red and near‐infrared wavelength‐induced photobiomodulation: promoting impaired cutaneous wound healing

Yadav, Anju; Gupta, Asheesh

doi:10.1111/phpp.12282

Cited by 99 publications

(55 citation statements)

References 45 publications

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“…IRA, as well as the red part of the visible spectrum, has been used in phototherapy for many years. It is administered as coherent (laser) or incoherent (various types of lamps) radiation, exploiting the photobiostimulatory effects to treat a lot of conditions of the skin, subcutaneous tissue and other tissues by accelerating wound healing, reducing inflammation and, in general, stimulating metabolism (see for instance [33,34]).…”

Section: Iramentioning

confidence: 99%

Balance between Health Risks and Benefits for Outdoor Workers Exposed to Solar Radiation: An Overview on the Role of Near Infrared Radiation Alone and in Combination with Other Solar Spectral Bands

Grandi

D’Ovidio

2020

IJERPH

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Near infrared or infrared A (IRA) accounts for over 40% of the solar spectrum (SS) and is able to reach subcutaneous tissue as well as the retina. Outdoor workers are occupationally exposed to solar radiation (SR), but the level of exposure may differ widely depending on the job performed, time spent outdoors, latitude, altitude, season, personal protection, etc. Until now, risk assessment and management for outdoor workers has focused on the prevention of both acute and long-term effects on the eye and the skin due to solar ultraviolet radiation (UVR) with little consideration of the other components of the SS (a possible exception is represented by visible radiation with reference to the eye). A growing body of evidence coming from in vitro studies indicates that IRA is involved in cellular reactive oxygen species (ROS) production and may interfere with the respiratory chain in the mitochondria. Moreover, it can modulate gene expression and some metabolic pathways. The biological action of IRA is only partly attributable to a thermal mechanism, should it be also involved in photochemical ones. The cellular and molecular pathways affected by IRA are partly similar and partly different with respect to those involved in the case of visible ultraviolet A (UVA) and ultraviolet B (UVB) radiation. Consequently, the net effect of the SS is very difficult to predict at different levels of the biological organization, making more difficult the final balance of health risk and benefits (for the skin, eye, immune system, blood pressure, etc.) in a given exposure situation. Moreover, few in vivo studies and no epidemiological data are presently available in this regard. Investigating this topic may contribute to better defining the individual exposome. More practically, it is expected to bring benefits to the risk assessment and management for outdoor workers exposed to SS, contributing to: (1) better definition of the individual profiles of susceptibility, (2) more focused preventive and protective measures, (3) better implementation of the health surveillance and (4) a more effective information and training.

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Section: Iramentioning

confidence: 99%

Balance between Health Risks and Benefits for Outdoor Workers Exposed to Solar Radiation: An Overview on the Role of Near Infrared Radiation Alone and in Combination with Other Solar Spectral Bands

Grandi

D’Ovidio

2020

IJERPH

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“…It has been demonstrated that polarized light at 590 nm stimulates angiogenesis and growth factors, while at 830 nm it activates the cells involved in wound healing; a dose of 20 J/cm 2 stimulates increased collagen deposition, an increase in myofibroblasts and a better ultrastructural organization of the wound healing process [9][10][11][12][13][14].…”

Section: Polarized Lightmentioning

confidence: 99%

From Tissue Repair to Tissue Regeneration

Emanuele¹,

Giada²,

Alessio³

et al. 2019

Wound Healing - Current Perspectives

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In Regeneration 3.0, the priority is to combine the anti-inflammatory activity of the nine proteins acting as growth factors in the bovine colostrum, the homeostatic, angiogenic and reorganizational activities of the matrix, the modulation of collagen synthesis and the remodeling of the epithelium. The choice of bovine colostrum and its associated properties was the basis for the design of devices that could also offer those properties: barrier action, anti-inflammatory action and pain reduction, reduction and absorption of exudates, combating of bacterial and fungal proliferation, antioxidant action and hydration and protection against skin diseases and dermatosis. We now know the key players in the wound healing process and we have new molecules available to act on them, but the future must necessarily lie in the transfer of molecules and information between the endothelium, ECM and cell membrane, which can be directed toward tissue regeneration if the resident stem cells have the chance of communicating and interacting with new therapeutic models, all this without forgetting that the human being is at the center of research and scientific evolution.

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“…Red light (630‐700 nm) has the greatest tissue penetration of the visible spectrum, reaching the entirety of the dermis at a depth of up to 6 mm . Light emitting diode‐red light (LED‐RL) phototherapy has been demonstrated to be safe and effective for wound healing, hair regrowth, acne vulgaris, skin rejuvenation, oral mucositis, skin cancers and premalignant skin lesions . LED‐RL activates cell signaling pathways that modulate skin cell function and translate to clinical benefits such as tissue regeneration and skin rejuvenation .…”

Section: Introductionmentioning

confidence: 99%

Safety of light emitting diode‐red light on human skin: Two randomized controlled trials

Jagdeo

Nguyen

et al. 2019

Journal of Biophotonics

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Therapeutic applications of light emitting diode‐red light (LED‐RL) are expanding, yet data on its clinical effects are lacking. Our goal was to evaluate the safety of high fluence LED‐RL (≥160 J/cm2). In two phase I, single‐blind, dose escalation, randomized controlled trials, healthy subjects received LED‐RL or mock irradiation to the forearm thrice weekly for 3 weeks at fluences of 160‐640 J/cm2 for all skin types (STARS 1, n = 60) and at 480‐640 J/cm2 for non‐Hispanic Caucasians (STARS 2, n = 55). The primary outcome was the incidence of adverse events (AEs). The maximum tolerated dose was the highest fluence that did not elicit predefined AEs. Dose‐limiting AEs, including blistering and prolonged erythema, occurred at 480 J/cm2 in STARS 1 (n = 1) and 640 J/cm2 in STARS 2 (n = 2). AEs of transient erythema and hyperpigmentation were mild. No serious AEs occurred. We determined that LED‐RL is safe up to 320 J/cm2 for skin of color and 480 J/cm2 for non‐Hispanic Caucasian individuals. LED‐RL may exert differential cutaneous effects depending on race and ethnicity, with darker skin being more photosensitive. These findings may guide future studies to evaluate the efficacy of LED‐RL for the treatment of various diseases.

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Noninvasive red and near‐infrared wavelength‐induced photobiomodulation: promoting impaired cutaneous wound healing

Cited by 99 publications

References 45 publications

Balance between Health Risks and Benefits for Outdoor Workers Exposed to Solar Radiation: An Overview on the Role of Near Infrared Radiation Alone and in Combination with Other Solar Spectral Bands

Balance between Health Risks and Benefits for Outdoor Workers Exposed to Solar Radiation: An Overview on the Role of Near Infrared Radiation Alone and in Combination with Other Solar Spectral Bands

From Tissue Repair to Tissue Regeneration

Safety of light emitting diode‐red light on human skin: Two randomized controlled trials

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