Noninvasive Subcellular Imaging in Breast Cancer Risk Assessment: Construction of Diagnostic Windows

Yeghiazaryan, Kristina; Cebioglu, Melanie; Braun, Michael; Kuhn, Walther; Schild, Hans H.; Golubnitschaja, Olga

doi:10.2217/pme.11.17

Cited by 7 publications

(11 citation statements)

References 21 publications

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“…In contrast, the breast cancer patients demonstrate much more heterogeneous image and general tendency to decrease after the 3rd life decade. These results have been published earlier [ 25 ] …”

Section: Discussionsupporting

confidence: 90%

“…This may be the case, if any stratified patient cohorts with primary breast cancer are identifiable as more resistant to irradiation compared to baseline. Some indications for this kind of evaluation have been published earlier by the authors [ 25 ]. This is to provide the main message from the previous study supporting current results and recommendations.…”

Section: Discussionmentioning

confidence: 99%

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Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

et al. 2016

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BackgroundPatients with primary and metastatic liver malignancies represent a highly heterogeneous patient pool characterised by some of the shortest life expectancies amongst oncology patients. Investigation and better understanding of liver malignancies is an emerging field which requires high-quality multidisciplinary research and collaboration.MethodsA study of 158 patients with primary hepatic carcinomas and secondary liver metastases, altogether 15 cancer types of different origin, who underwent selective internal radiation therapy (SIRT) with Yttrium90 or transarterial chemoembolisation, was undertaken in an effort to detect distinguishing features with respect to activity profiles of both blood matrix metalloproteinase (MMP-2 and MMP-9).ResultsNoteworthy, stratification of all hepatic cancer groups with respect to MMP-2 and MMP-9 activities revealed characteristic patterns specifically in patients with hepatic breast cancer metastases who had undergone SIRT. In contrast to all other groups, these patients demonstrated well-consolidated profiles of both MMPs, reflecting a common feature, namely an immediate and durable increase of their activity after the SIRT treatment. Although the total number of patients in the breast cancer group is relatively small (15 patients), since increased activities of MMP-2 and MMP-9 are well known prognostic factors for poor outcomes of oncologic patients, the significance and clear group-specificity (from 15 ones investigated here) of this previously unanticipated finding requires particular attention and further investigations. Particularly important is to determine, whether this increase of the metalloproteinase activity was provoked by SIRT, as well as whether special selection criteria are required for patients with breast cancer metastases to the liver who are being considered for SIRT.ConclusionsIt is recommended that a more focused, multidisciplinary and large-scaled investigations of the possible adverse effects of SIRT in patients with advanced metastatic disease of breast cancer be undertaken, with an appropriate patients’ stratification, set-up of the relevant patient profiles and disease modelling.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

et al. 2016

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“…An example of the diagnostic windows for breast cancer risk assessment using comet classes I (intact DNA) and IV (apoptotic) is demonstrated in Figure 4[36]. The constructed diagnostic windows clearly distinguish between tumour and benign patients and may be considered for the practical application in differential molecular diagnostics.…”

Section: Reviewmentioning

confidence: 99%

“… Diagrams estimating a predictive power of the comet-fractions (comet class I and IV), further utilised in the construction of diagnostic windows for breast cancer risk assessment (A, B and C); according to the diagnosis, the recruited patients are grouped as follows: pre-menopausal women with benign alterations in breast tissue (G1); post-menopausal women with benign alterations in breast tissue (G2); invasive lobular & ductal carcinomas in pre-menopausal women (G3); invasive lobular & ductal carcinomas in post-menopausal women (G4); data taken from [36] . Obviously, the diagnostic windows with the comet class IV patterns can be effective only when the hormonal status is considered as one of the selection parameters for subgrouping the patients and concomitant utilisation of the analytical approach proposed by this study.…”

Section: Reviewmentioning

confidence: 99%

Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?

Golubnitschaja

Yeghiazaryan

Costigliola³

et al. 2013

EPMA Journal

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Breast cancer is a multifactorial disease. A spectrum of internal and external factors contributes to the disease promotion such as a genetic predisposition, chronic inflammatory processes, exposure to toxic compounds, abundant stress factors, a shift-worker job, etc. The cumulative effects lead to high incidence of breast cancer in populations worldwide. Breast cancer in the USA is currently registered with the highest incidence rates amongst all cancer related patient cohorts. Currently applied diagnostic approaches are frequently unable to recognise early stages in tumour development that impairs individual outcomes. Early diagnosis has been demonstrated to be highly beneficial for significantly enhanced therapy efficacy and possibly full recovery. Actual paper shows that the elaboration of an integrative diagnostic approach combining several levels of examinations creates a robust platform for the reliable risk assessment, targeted preventive measures and more effective treatments tailored to the person in the overall task of breast cancer management. The levels of examinations are proposed, and innovative technological approaches are described in the paper. The absolute necessity to create individual patient profiles and extended medical records is justified for the utilising by routine medical services. Expert recommendations are provided to promote further developments in the field.

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“…Metabolomic investigations (plasma folate, vitamin B6, vitamin B12, homocysteine) revealed alteration of breast cancer risks specifically in premenopausal women [21]. Finally, subcellular imaging of chromosomal DNA by the Comet Assay analysis has indicated differentiation of the Bcomet profiles^between younger and older breast cancer patients [22,23].…”

Section: Introductionmentioning

confidence: 99%

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification

et al. 2018

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The study resulted in identifying multi-omic signature specific for the premenopausal BC that can be used for stratifying patients with benign breast alterations. Our predictive model is capable of discriminating individually between high and low BC-risk with high confidence (>90%) and considered of potential clinical utility. Novel risk assessment approaches and advanced screening programmes-as the long-term target of this project-are of particular importance for predictive, preventive and personalised medicine as the medicine of the future, due to the expected health benefits for young subpopulations and the healthcare system as a whole.

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Noninvasive Subcellular Imaging in Breast Cancer Risk Assessment: Construction of Diagnostic Windows

Cited by 7 publications

References 21 publications

Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours

Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification

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