Noninvasive surrogate markers of atherosclerosis

Feinstein, Steven B.; Voci, Paolo; Pizzuto, Francesco

doi:10.1016/s0002-9149(02)02226-9

Cited by 66 publications

(36 citation statements)

References 53 publications

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“…In addition, carotid intima-media thickness (IMT) and carotid plaque have been reported to be independent predictors of CAD 11,12) . These noninvasive imaging modalities are useful surrogate markers for future cardiovascular events 13) . We previously reported that the amount of oxidative stress in the aorta might be an important factor leading to vascular dysfunction, as assessed by arterial stiffness 14) , and that the decreased superoxide content of the aorta caused by lipid-lowering drugs through antioxidant mechanisms independent of lipid-lowering effects may inhibit the progression of atherosclerosis and arterial stiffness in persons with hypercholesterolemia 15) , suggesting that oxidative stress may be one of the important determinants of arterial stiffness in hypercholesterolemia.…”

Section: Study Design and Patient Populationmentioning

confidence: 99%

Add-on Therapy of EPA Reduces Oxidative Stress and Inhibits the Progression of Aortic Stiffness in Patients with Coronary Artery Disease and Statin Therapy: A Randomized Controlled Study

Takaki

Umemoto

Ono

et al. 2011

JAT

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Aim:We examined the anti-oxidant mechanisms of combined therapy of eicosapentaenoic acid (EPA) plus statin on the progression of atherosclerosis. Methods: Patients receiving statin therapy for dyslipidemia and with coronary artery disease (CAD) were assigned randomly in an open-label manner to the EPA (1,800 mg/day) -plus-statin group (n 25; combined-therapy group) or to the statin-only group (n 25), and followed for 48 weeks. At baseline and 48 weeks after enrollment, oxidative stress, brachial-ankle pulse wave velocity (baPWV) and stiffness parameter -index of the carotid were measured. Results: The lipid profile remained unchanged throughout the study. Although the median value of baPWV increased more in the statin-only group than in the combined-therapy group, this difference was not significant (p 0.29); however, a decrease in baPWV was associated with combined-therapy treatment by multiple regression analysis adjusted for age and mean blood pressure (p 0.04). In addition, the -index of the carotid was lower in the combined-therapy group than in the statin-only group (p 0.02). Furthermore, although the difference in the reduction of the urinary concentration of 8-isoprostane between the two groups did not reach statistical significance, this concentration was significantly lower in the combined-therapy group with higher baseline levels ( ≥ 183 pg/mL · Cr) of urinary 8-isoprostane (p 0.004). Conclusions: EPA may reduce oxidative stress and inhibit the progression of arterial stiffness more efficiently than statin-only therapy in patients with dyslipidemia and CAD. J Atheroscler Thromb, 2011; 18:857-866.

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Section: Study Design and Patient Populationmentioning

confidence: 99%

Add-on Therapy of EPA Reduces Oxidative Stress and Inhibits the Progression of Aortic Stiffness in Patients with Coronary Artery Disease and Statin Therapy: A Randomized Controlled Study

Takaki

Umemoto

Ono

et al. 2011

JAT

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show abstract

“…16 Yet most patients with symptomatic CVD have similar levels of traditional risk factors, and all have atherosclerosis to a greater or lesser degree. 17 Probably, apart from the extent of coronary atherosclerosis, the sensitivity of organs to episodes of ischemia is of importance. Therefore, other factors may play a role as well: notably, the presence of a collateral circulation.…”

Section: Risk Factors Of Cvdmentioning

confidence: 99%

“…18,17 Important factors that have been shown to negatively affect myocardial vulnerability include left ventricular hypertrophy (LVH), diastolic heart failure, and previous MI. These conditions are frequently present in older individuals.…”

Section: Myocardial Vulnerabilitymentioning

confidence: 99%

Coronary Collaterals

et al. 2003

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“…The results of this study are consistent with large cohort studies in which decreased ABI is a marker for cardiovascular events. 4,8,23 Recently, coronary calcium detected by electron beam computed tomography (EBCT) was proposed as a screening test before stress myocardial imaging to identify intermediate-or high-risk subsets of CAD patients. 24 Compared with EBCT, simultaneous brachial and ankle blood pressure measurements are much simpler to perform and provide important information about intermediate-or high-risk populations or for the management of patients suspected of having CAD.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 In one study, the Gensini score was calculated to evaluate the extent and severity of coronary atherosclerosis, though this is not commonly used in clinical practice. 5 In contrast, scintigraphic scores for myocardial ischemia are widely accepted, well-known markers for prognosis, 25 and because of its noninvasiveness, this myocardial imaging technique can evaluate the extent and severity of coronary atherosclerosis not only in selected patients who have sufficient risks to warrant CAG, but also in the wider patient population that includes a low-risk subset.…”

Section: Discussionmentioning

confidence: 99%