Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance

Niu, Lili; Guo, Yanchen; Lin, Zhengrong; Shi, Zhe; Bian, Tianyuan; Qi, Lin; Meng, Long; Grace, Anthony A.; Zheng, Hairong; Yuan, Ti‐Fei

doi:10.1007/s11427-019-1616-6

Cited by 21 publications

(12 citation statements)

References 26 publications

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“…US stimulation induced aversive responses with 0.1 MPa US in EYFP mice (Fig. 3D, E), consistent with previous reports [21]. Increasing acoustic pressure to 0.15 MPa in EYFP mice further aversive behavior (Fig.…”

Section: Efficient Dopamine Release and Appetitive Conditioning By Mscl-sonogenetics Modulation Of Vta Reward Circuitrysupporting

confidence: 92%

Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

Xian¹,

Qiu²,

Kala³

et al. 2021

Preprint

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Sonogenetics uses heterologously-expressed proteins to sensitize neurons to ultrasound, enabling selective, non-invasive, and deep brain stimulation. However, its ability to modulate specific circuits or induce behavioral changes remains to be studied and characterized. Here, we demonstrate that sonogenetics enables efficient activation of well-defined neural circuits by transcranial low-intensity, low-frequency ultrasonic stimulation with high spatiotemporal resolution. Targeted neurons in subcortical regions were made to express a mechanosensitive ion channel (MscL-G22S). Ultrasound could trigger activity in MscL-expressing neurons in the dorsal striatum without increased activation in neighboring regions, and increase locomotion in freely-moving mice. Ultrasound stimulation of MscL-expressing neurons in the ventral tegmental area could activate the mesolimbic pathway to trigger dopamine release in the nucleus accumbens and modulate appetitive conditioning. In MscL-expressing cells, neuronal responses to ultrasound pulses were rapid, reversible and repeatable. Altogether, we show that sonogenetics can selectively manipulate targeted cells to activate defined neural pathways and affect behaviors.

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Section: Efficient Dopamine Release and Appetitive Conditioning By Mscl-sonogenetics Modulation Of Vta Reward Circuitrysupporting

confidence: 92%

Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

Xian¹,

Qiu²,

Kala³

et al. 2021

Preprint

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“…Thus, finding strategies to avoid the potential adverse effects of torpor on cognition and mental health, and regaining normal brain functions after arousal from prolonged synthetic torpor in humans, remains a primary goal. Combining non‐invasive neuromodulation technologies, such as transcranial magnetic stimulation (TMS) and ultrasound deep brain stimulation (DBS), with neuroimaging and electrophysiology could provide a safe strategy to monitor real‐time neuronal activity of specific brain functions while modulating target regions into chosen active states (Bergmann et al ., 2016; Shen et al ., 2016; Liang, Wang & Yuan, 2018; Lin et al ., 2019; Liu et al ., 2019; Niu et al ., 2020).…”

Section: Discussionmentioning

confidence: 99%

Human torpor: translating insights from nature into manned deep space expedition

et al. 2020

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During a long‐duration manned spaceflight mission, such as flying to Mars and beyond, all crew members will spend a long period in an independent spacecraft with closed‐loop bioregenerative life‐support systems. Saving resources and reducing medical risks, particularly in mental heath, are key technology gaps hampering human expedition into deep space. In the 1960s, several scientists proposed that an induced state of suppressed metabolism in humans, which mimics ‘hibernation’, could be an ideal solution to cope with many issues during spaceflight. In recent years, with the introduction of specific methods, it is becoming more feasible to induce an artificial hibernation‐like state (synthetic torpor) in non‐hibernating species. Natural torpor is a fascinating, yet enigmatic, physiological process in which metabolic rate (MR), body core temperature (Tb) and behavioural activity are reduced to save energy during harsh seasonal conditions. It employs a complex central neural network to orchestrate a homeostatic state of hypometabolism, hypothermia and hypoactivity in response to environmental challenges. The anatomical and functional connections within the central nervous system (CNS) lie at the heart of controlling synthetic torpor. Although progress has been made, the precise mechanisms underlying the active regulation of the torpor–arousal transition, and their profound influence on neural function and behaviour, which are critical concerns for safe and reversible human torpor, remain poorly understood. In this review, we place particular emphasis on elaborating the central nervous mechanism orchestrating the torpor–arousal transition in both non‐flying hibernating mammals and non‐hibernating species, and aim to provide translational insights into long‐duration manned spaceflight. In addition, identifying difficulties and challenges ahead will underscore important concerns in engineering synthetic torpor in humans. We believe that synthetic torpor may not be the only option for manned long‐duration spaceflight, but it is the most achievable solution in the foreseeable future. Translating the available knowledge from natural torpor research will not only benefit manned spaceflight, but also many clinical settings attempting to manipulate energy metabolism and neurobehavioural functions.

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“…In particular, rTMS has been shown to reduce heroin and methamphetamine craving ( 74 , 75 ). Interestingly, repeated NAc ultrasound stimulation also suppressed morphine CPP, suggesting NAc ultrasound stimulation might also be applied as a potential non-invasive therapeutic option in treating addiction ( 76 ). However, the effectiveness of these non-invasive methods in drug addiction treatment needs to be verified with larger clinic trials.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Deep Brain Stimulation in Drug Addiction Treatment: Research Progress and Perspective

et al. 2022

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Drug addiction is a chronic psychiatric disorder characterized by compulsive drug-seeking and drug-using behavior, and a tremendous socioeconomic burden to society. Current pharmacological and psychosocial methods have shown limited treatment effects for substance abuse. Deep Brain Stimulation (DBS) is a novel treatment for psychiatric disease and has gradually gained popularity in the treatment of addiction. Addiction is characterized by neuroplastic changes in the nucleus accumbens (NAc), a key structure in the brain reward system, and DBS in this region has shown promising treatment effects. In this paper, the research progress on DBS for drug addiction has been reviewed. Specifically, we discuss the mechanism of NAc DBS for addiction treatment and summarize the results of clinical trials on DBS treatment for addiction to psychoactive substances such as nicotine, alcohol, cocaine, opioids and methamphetamine/amphetamine. In addition, the treatment effects of DBS in other brain regions, such as the substantia nigra pars reticulata (SNr) and insula are discussed.

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Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance

Cited by 21 publications

References 26 publications

Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

Human torpor: translating insights from nature into manned deep space expedition

Deep Brain Stimulation in Drug Addiction Treatment: Research Progress and Perspective

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