Noninvasive Ventilation and High-Flow Nasal Cannulae Therapy for Children with Acute Respiratory Failure: An overview

Al-Mukhaini, Khaloud S.; Al-Rahbi, Najwa

doi:10.18295/squmj.2018.18.03.003

Cited by 7 publications

(1 citation statement)

References 61 publications

(128 reference statements)

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“…3 Although the use of HFNC in the pediatric population remains poorly understood, based on observational and randomized clinical trials done in infants with bronchiolitis, there was a reduction in the number of patients who needed intubation. [4][5][6] The e cacy and safety of HFNC made its use not only in pediatric intensive care unit (PICU), but also in the emergency department, and general ward. Although proper and close monitoring by trained staff is still necessary.…”

Section: Introductionmentioning

confidence: 99%

Respiratory Rate Oxygenation (ROX) Index as Predictor of High Flow Nasal Cannula in Pediatric Patients in Pediatric Intensive Care Unit dr Cipto Mangunkusumo Hospital

Yuniar,

Pudjiadi,

Dewi

et al. 2024

Preprint

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Background High-flow nasal cannula (HFNC) is often used in pediatric populations with respiratory distress. In adults, the respiratory-rate oxygenation (ROX) index is used as a predictor of HFNC therapy; however, children have age-associated differences in respiratory rate, thus may not be applicable to children. This study aims to find the reliability of ROX index and modified P-ROX index as predictors of HFNC therapy failure in pediatric patients. Methods Subjects in this analytical cross-sectional study were taken from January 2023 until November 2023 in Cipto Mangunkusumo Hospital. Inclusion criteria are children aged 1 month to 18 years with respiratory distress and got HFNC therapy. Receiver operating characteristics (ROC) analysis was used to find mP-ROX index cutoff value as a predictor of HFNC failure. The area under curve (AUC) score of mP-ROX index was assessed at different time point. Results A total of 102 patients, with 70% of the population with pneumonia, were included in this study. There are significant differences in the ROX index between the successful and failed HFNC group therapy (p < 0.05). This study suggests that mP-ROX index is not useful as predictor of HFNC therapy in pediatrics. While ROX index < 5.52 at 60 minutes and < 5.68 at 90 minutes after HFNC initiation have a sensitivity of 90% and specificity of 71%, sensitivity of 78% and specificity of 76%, respectively. Conclusion mP-ROX index is not useful as a predictor of HFNC therapy in pediatrics. Meanwhile, ROX index at 60 minutes and 90 minutes after initiation of HFNC is useful as a predictor of HFNC failure.

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Section: Introductionmentioning

confidence: 99%

Respiratory Rate Oxygenation (ROX) Index as Predictor of High Flow Nasal Cannula in Pediatric Patients in Pediatric Intensive Care Unit dr Cipto Mangunkusumo Hospital

Yuniar,

Pudjiadi,

Dewi

et al. 2024

Preprint

View full text Add to dashboard Cite

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Unusual and Emergent New Indications for Noninvasive Mechanical Ventilation

Pinto,

Rodrigues,

Santos

2023

Noninvasive Mechanical Ventilation

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Respiratory Rate Oxygenation (ROX) index as predictor of high flow nasal cannula in pediatric patients in pediatric intensive care unit

Yuniar,

Pudjiadi,

Dewi

et al. 2024

BMC Pulm Med

View full text Add to dashboard Cite

Background High-flow nasal cannula (HFNC) is often used in pediatric populations with respiratory distress. In adults, the respiratory-rate oxygenation (ROX) index is used as a predictor of HFNC therapy; however, children have age-associated differences in respiratory rate, thus may not be applicable to children. This study aims to find the reliability of ROX index and modified P-ROX index as predictors of HFNC therapy failure in pediatric patients. Methods Subjects in this analytical cross-sectional study were taken from January 2023 until November 2023 in Cipto Mangunkusumo Hospital. Inclusion criteria are children aged 1 month to 18 years with respiratory distress and got HFNC therapy. Receiver operating characteristics (ROC) analysis was used to find mP-ROX index cutoff value as a predictor of HFNC failure. The area under curve (AUC) score of mP-ROX index was assessed at different time point. Results A total of 102 patients, with 70% of the population with pneumonia, were included in this study. There are significant differences in the ROX index between the successful and failed HFNC group therapy (p < 0.05). This study suggests that mP-ROX index is not useful as predictor of HFNC therapy in pediatrics. While ROX index < 5.52 at 60 min and < 5.68 at 90 min after HFNC initiation have a sensitivity of 90% and specificity of 71%, sensitivity of 78% and specificity of 76%, respectively. Conclusion mP-ROX index is not useful as a predictor of HFNC therapy in pediatrics. Meanwhile, ROX index at 60 min and 90 min after initiation of HFNC is useful as a predictor of HFNC failure.

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Noninvasive Ventilation and High-Flow Nasal Cannulae Therapy for Children with Acute Respiratory Failure: An overview

Cited by 7 publications

References 61 publications

Respiratory Rate Oxygenation (ROX) Index as Predictor of High Flow Nasal Cannula in Pediatric Patients in Pediatric Intensive Care Unit dr Cipto Mangunkusumo Hospital

Respiratory Rate Oxygenation (ROX) Index as Predictor of High Flow Nasal Cannula in Pediatric Patients in Pediatric Intensive Care Unit dr Cipto Mangunkusumo Hospital

Unusual and Emergent New Indications for Noninvasive Mechanical Ventilation

Respiratory Rate Oxygenation (ROX) index as predictor of high flow nasal cannula in pediatric patients in pediatric intensive care unit

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