Noninvasive visualization of electrical conductivity in tissues at the micrometer scale

Huang, Yuanhui; Omar, Murad; Tian, Weili; López‐Schier, Hernán; Westmeyer, Gil G.; Chmyrov, Andriy; Sergiadis, George D.; Ntziachristos, Vasilis

doi:10.1126/sciadv.abd1505

Cited by 12 publications

(6 citation statements)

References 55 publications

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“…Huang el al. investigated the TA imaging of zebrafish embryos, and non‐invasively visualised the distribution of the conductivity (Figure 7a) [36]. Microwave can also activate the nanomaterials to generate nanobubbles or local toxic molecules in the targeted biological cells; and thereby TA effect has potential application as non‐invasive medical therapy technology.…”

Section: Dielectrics Materials In Biologymentioning

confidence: 99%

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Wang,

Huang,

Zhang

et al. 2023

IET Nanodielectrics

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We have witnessed the flourish of bioelectronics, brain–computer interface, and brain science programme in recent decades. In this review, the up‐to‐date advances of dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications are summarised. Biomolecular detection methods have been developed, including dielectric‐gated field‐effect transistor, dielectrophoresis, non‐linear dielectric response, and optical tweezer. Endogenous bioelectricity is a crucial in cell proliferation, migration, differentiation, intracellular communication, neuronal activity, tissue growth. Piezoelectric and ferroelectric materials can be utilised as energy transducer to monitor physiological signal, such as blood pressure or respiration, and directly stimulate cell differentiation, neuronal regeneration, tissue repairment etc. They can also catalyse the electrochemical reaction of organisms through piezoelectricity. The intrinsic relevance between neuronal and ferroelectric polarisation signals inspires the application of the ferroelectrics in the modern intelligent bioelectronics like the artificial retina.

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Section: Dielectrics Materials In Biologymentioning

confidence: 99%

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Wang,

Huang,

Zhang

et al. 2023

IET Nanodielectrics

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“…国外Kruger等 [74] 首次将微波热声成像技术应用于乳腺癌检测, 结果表明, 基于病变区域与正常组织的微波吸收差异, 获得的肿瘤图像比正常组织图像对比度提升了约两倍. 国内蒋华北教授团队 [49] 成功对乳腺仿体进行了成像, 覃欢团队 [16,75] 图 4 微波热声成像乳腺成像 (a) Kruger等 [74] 的乳腺成像图; (b) 微波热声乳腺成像实操图 [16] ; (c) 乳房的解剖结构示意图 [16] ; (d) 覃欢团队 [16] 乳腺成像图 Fig. 4.…”

Section: 微波乳腺热声成像unclassified

Biomedical microwave-induced thermoacoustic imaging

Yu¹,

Zhang²,

Qin³

2023

Acta Phys. Sin.

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Microwave Thermoacoustic Imaging (MTAI) is an exciting imaging technique rooted in the underlying principle of exploiting the distinct electrical properties of biological tissues. By harnessing short-pulsed microwaves as a stimulation source and leveraging their interaction with the human body, MTAI has paved the way for revolutionary advancements in medical imaging. When microwaves are absorbed by polar molecules and ions within the tissues, an ingenious thermoelastic effect gives rise to ultrasound waves. These ultrasound waves, brimming with invaluable pathological and physiological insights, propagate outward, carrying the essence of the biological tissue's composition and functionality. Through a meticulous collection of ultrasound signals from all directions surrounding the tissue, it becomes possible to reconstruct intricate internal structures and visualize the tissue's functional dynamics. MTAI excels in non-invasiveness, capable of delving several centimeters beneath the surface with a microscopic resolution on the order of micrometers. The magic lies in the transformative conversion of microwave energy into ultrasound waves, tapping into the tissue's hidden depths without causing harm. This groundbreaking imaging modality unlocks a realm of possibilities for acquiring profound insights into the intricate structures and functionality of deep-seated tissues. Furthermore, the inherent polarization characteristics of microwaves empower MTAI to capture additional dimensions of information, unraveling the intricate polarization properties and illuminating a richer understanding of the tissue's complexity. The immense potential of MTAI extends far and wide within the realm of medicine. It has already demonstrated remarkable achievements in non-invasively imaging brain structures, screening for breast tumors, visualizing arthritis in human joints, and detecting liver fat content. These accomplishments have laid a solid foundation, firmly establishing MTAI as a trailblazing medical imaging technique. This article offers a comprehensive and in-depth exploration of the physical principles underpinning MTAI, the sophisticated system devices involved, and the recent groundbreaking research breakthroughs. Moreover, it delves into the exciting prospects and challenges that lie ahead in the future development of MTAI. As the technology continues to progress by leaps and bounds, MTAI is poised to shatter barriers, ushering in a new era of unrivaled imaging quality and performance. This, in turn, will open the floodgates for transformative innovation and application in the realms of medical diagnosis and treatment. The anticipation is palpable as MTAI strives to make substantial contributions to the ever-evolving field of medical imaging, bestowing upon humanity more precise, reliable, and life-enhancing diagnostic capabilities.

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“…In recent years, TAT has been developed in many aspects, such as thermoacoustic mesoscopy, compressive sensing TAT, thermoacoustic endoscopy, multimodality imaging, thermoacoustic molecular imaging, and low-cost portable TAT systems. [20][21][22][23][24][25][26] With the unique advantages and rapid development, TAT has been thus far applied to detection of breast and prostate cancers, imaging of brain, joints/bone, blood vessels, and liver imaging. [27][28][29][30][31][32][33][34][35][36][37][38] For joint imaging, nonionizing TAT can preferably image soft tissue compared with X-ray and CT, which can image bone clearly.…”

Section: Introductionmentioning

confidence: 99%

“…As a hybrid modality, TAT combines the advantages of high electromagnetic contrast and high ultrasonic resolution. In recent years, TAT has been developed in many aspects, such as thermoacoustic mesoscopy, compressive sensing TAT, thermoacoustic endoscopy, multimodality imaging, thermoacoustic molecular imaging, and low‐cost portable TAT systems 20–26 . With the unique advantages and rapid development, TAT has been thus far applied to detection of breast and prostate cancers, imaging of brain, joints/bone, blood vessels, and liver imaging 27–38 .…”

Section: Introductionmentioning

confidence: 99%

First assessment of thermoacoustic tomography for in vivo detection of rheumatoid arthritis in the finger joints

Chi

Huang

et al. 2021

Medical Physics

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Background: The diagnosis of rheumatoid arthritis (RA) is complicated because of the complexity of symptoms and joint structures. Current clinical imaging techniques for the diagnosis of RA have strengths and weaknesses. Emerging imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of RA.Purpose: This study aimed to demonstrate the potential of thermoacoustic tomography (TAT) for in vivo detection of RA in the finger joints. Methods: Finger joints were imaged by a TAT system using three different microwave illumination methods including pyramidal horn antenna, and parallel in-phase and anti-phase microwave illuminations. Both diseased and healthy joints were imaged and compared when the three microwave illumination methods were used. Magnetic resonance imaging (MRI) of all the joints was performed to validate the TAT findings. In addition, two diseased joints were imaged at two time points by the pyramidal horn antenna-based TAT to track/monitor the progression of RA during a time period of 16 months. Three-dimensional (3-D) TAT images of the joints were also obtained. Results:The TAT images of the diseased joints displayed abnormalities in bone and soft tissues compared to the healthy ones. The TAT images by pyramidal horn antenna and in-phase microwave illumination showed high similarity in image appearance, while the anti-phase-based TAT images provided different information about the disease. We found that the TAT findings matched well with the MRI images. The 3-D TAT images effectively displayed the stereoscopic effect of joint lesions. Finally, it was evident that TAT could detect the development of the lesions in 16 months. Conclusion: TAT can noninvasively visualize bone lesions and soft tissue abnormalities in the joints with RA. This first in vivo assessment of TAT provides a foundation for its clinical application to the diagnosis and monitoring of RA in the finger joints.

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Noninvasive visualization of electrical conductivity in tissues at the micrometer scale

Cited by 12 publications

References 55 publications

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Dielectric, piezoelectric, and ferroelectric nanomaterials in the biomedical applications

Biomedical microwave-induced thermoacoustic imaging

First assessment of thermoacoustic tomography for in vivo detection of rheumatoid arthritis in the finger joints

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