2024
DOI: 10.1002/adma.202403198
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Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells

Monica L. Ohnsorg,
Kayla M. Mash,
Alex Khang
et al.

Abstract: The nonlinear elasticity of many tissue‐specific extracellular matrices is difficult to recapitulate without the use of fibrous architectures, which couple strain‐stiffening with stress relaxation. Herein, bottlebrush polymers are synthesized and crosslinked to form poly(ethylene glycol)‐based hydrogels and used to study how strain‐stiffening behavior affects human mesenchymal stromal cells (hMSCs). By tailoring the bottlebrush polymer length, the critical stress associated with the onset of network stiffening… Show more

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