“…Taking the characteristic distributions of MRI data into consideration, noise can be compensated. Numerous approaches have been proposed using MRI magnitude data to compensate for noise, using a variety of methods including total variation [23][24][25], analyzing multiple scales using wavelet denoising [26][27][28], via non-local means [13,22,[29][30][31] and linear minimum mean-square estimators (LMMSE) [14,32]. These approaches combine a mixture of techniques to handle the particular nature of MRI noise: spatialadaptation to the noise variance [11,24,29,33], Rician distribution [24,25,28,29,34] and accounting for Figure 1.…”