Nonlinear intravascular ultrasound contrast imaging

Goertz, David E.; Frijlink, M.E.; Jong, Nico de; Steen, Antonius F.W. van der

doi:10.1016/j.ultrasmedbio.2006.01.001

Cited by 83 publications

(63 citation statements)

References 39 publications

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“…3(d)). This agent has been found to have significant nonlinear activity at transmit frequencies from 20 to 40 MHz [5,7]. It is also notable that the form of the attenuation curve for this agent (comprised of micron to submicron sized bubbles) is intermediate between 1 and 2 lm filtration results.…”

Section: Agentmentioning

confidence: 98%

“…Several studies have investigated their use in 'linear' imaging mode using ultrasound biomicroscopy [1] and intravascular ultrasound (IVUS) systems [2,3]. More recent work has shown that it is also feasible to perform subharmonic and second harmonic imaging at high frequencies [4,5]. In these studies, both conventional commercial agents and experimental liposomal preparations with micron to submicron mean diameters have been employed.…”

Section: Introductionmentioning

confidence: 99%

“…From an experimental perspective, it has been shown that mechanical filtration of BR14 (Bracco Research, Geneva) [6]. Further, the experimental micron to submicron lipid encapsulated agent BG2423 (Bracco Research, Geneva) has been shown to have substantial nonlinear activity (subharmonics and second harmonics) for transmit frequencies of 20-40 MHz [5,7].…”

Section: Introductionmentioning

confidence: 99%

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High frequency attenuation measurements of lipid encapsulated contrast agents

et al. 2006

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A number of recent studies have indicated the potential of ultrasound contrast agent imaging at high ultrasound frequencies. However, the acoustic properties of microbubbles at frequencies above 10 MHz remain poorly understood at present. In this study we characterize the high frequency attenuation properties of (1) BR14, (2) BR14 that has been mechanically filtered (1 and 2 lm pore sizes) to exclude larger bubbles, and (3) the micron to submicron agent BG2423. A narrowband pulse-echo substitution method is employed with a series of four transducers covering the frequency range from 2 to 50 MHz. For BR14, attenuation decreases rapidly from 2 to 10 MHz and then more gradually from 10 to 50 MHz. For 2 lm filtration, the attenuation peaks between 10 and 15 MHz. For 1 lm filtration, attenuation continues to rise until 50 MHz. The agent BG2423 exhibits a diffuse attenuation peak in the range of 15-25 MHz and remains high until 50 MHz. These results demonstrate a strong influence of bubble size on high frequency attenuation curves, with bubble diameters of 1-2 lm and below having more pronounced acoustic activity at frequencies above 10 MHz.

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Section: Agentmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High frequency attenuation measurements of lipid encapsulated contrast agents

et al. 2006

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“…132,133 Detection may be enhanced with the use of harmonic imaging after microbubble injection in which the signal is recorded at a higher frequency than that of the sonic waves directed to the plaque. 134 Elastography IVUS can also be used to assess the deformation of plaques during the changes in intracoronary pressure that occur during the cardiac cycle. 135 This technique, called elastography, has been used to characterize the softness of plaques, which might be a sign of vulnerability.…”

Section: Detection Of Ruptured Plaque By Ivusmentioning

confidence: 99%

Detection and Treatment of Vulnerable Plaques and Vulnerable Patients

2006

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“…The observation of harmonics was unexpected because few UCAs in the submicron size range are expected to exist in a given dose, and, from the theory of free bubbles, the expectation is that relatively high pressures would be required to excite a bubble nonlinearly with HFU. In subsequent studies, Goertz et al 10,11 also observed harmonic backscatter from Optison™ ͑GE Healthcare, Chalfont St. Giles, UK͒ and a Bracco agent ͑Princeton, NJ͒, although at a much weaker pressure level than observed with Definity®. Theoretical work by Allen et al 12 suggested that shell waves may contribute to high-frequency backscatter components in lipid-shelled UCAs.…”

Section: Introductionmentioning

confidence: 93%

Subharmonic analysis using singular-value decomposition of ultrasound contrast agents

Mamou

Ketterling

2009

The Journal of the Acoustical Society of America

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Ultrasound contrast agents ͑UCAs͒ are designed to be used below 10 MHz, but interest is growing in studying the response of agents to high-frequency ultrasound. In this study, the subharmonic response of polymer-shelled UCAs with a mean diameter of 1.1 m excited with 40-MHz tone-bursts of 1 -20 cycles was analyzed. UCAs were diluted in water and streamed through a flow phantom that permitted single-bubble backscatter events to be acquired at peak-negative pressures from 0.75 to 5.0 MPa. At each exposure condition, 1000 single-bubble-backscatter events were digitized. Subharmonic content at 20 MHz was screened using a conventional and a singular-value-decomposition ͑SVD͒ method. The conventional method evaluated each event spectrum individually while the SVD method treated the 1000-event data set at one time. A subharmonic score ͑SHS͒ indicative of how much subharmonic content a 1000-event data set contained was computed for both methods. Empirical-simulation results indicated that SHSs obtained from the two methods were linearly related. Also, experimental data with both methods indicated that subharmonic likelihood increased with pulse duration and peaked near 2 MPa. The SVD method also yielded quantitative information about subharmonic events not available with the conventional method.

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Nonlinear intravascular ultrasound contrast imaging

Cited by 83 publications

References 39 publications

High frequency attenuation measurements of lipid encapsulated contrast agents

High frequency attenuation measurements of lipid encapsulated contrast agents

Detection and Treatment of Vulnerable Plaques and Vulnerable Patients

Subharmonic analysis using singular-value decomposition of ultrasound contrast agents

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