Let A and B be two factor von Neumann algebras. For A 1 , A 2 , · · · , A n (n ≥ 2) ∈ A define by A 1 • A 2 • · · · • A n the Jordan multiple * −product in any fixed operation order. In this article, it is proved that a not necessarily linear bijective mappingis a * −ring isomorphism. In particular, if the von Neumann algebras A and B are type I factors, then is a unitary isomorphism or a conjugate unitary isomorphism.