Nonlinear micro finite element models based on digital volume correlation measurements predict early microdamage in newly formed bone

Fernández, Marta Peña; Sasso, Sebastian J.; McPhee, Samuel; Black, Cameron; Kanczler, Janos M.; Tozzi, Gianluca; Wolfram, Uwe

doi:10.1016/j.jmbbm.2022.105303

Cited by 14 publications

(7 citation statements)

References 94 publications

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“…BV/TV) provided a good representation of the differences observed between groups ( Figure 3 ). In addition, this analysis may be combined with computational models 39 in larger sample sizes and whole defect regions to improve the current understanding between bone regeneration achieved in vivo by the action of different biomaterials and mechanical competence. Nevertheless, importantly, the analysis corroborated the morphometric data obtained on a larger cohort.…”

Section: Discussionmentioning

confidence: 99%

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model

et al. 2022

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Development of a growth factor delivery vehicle providing appropriate temporal-spatial release together with an appropriate preclinical large animal model to evaluate bone formation is critical in the development of delivery strategies for bone tissue regeneration. Smectite nanoclays such as LAPONITE™ possess unique thixotropic and protein retention properties offering promise for use in growth factor delivery in bone repair and regeneration. This study has examined bone formation mediated by a clinically approved growth factor delivery system (InductOs®) in combination with Laponite gel in an aged female ovine femoral condyle defect preclinical model (10 weeks). Two different designs, one containing a low volume of Laponite gel (LLG) in combination with the InductOs® absorbable collagen sponge (ACS), the other in which Laponite gel formed the implant (HLG), were compared against InductOs® alone and an autograft positive control. Thus, five groups: (i) empty defect, (ii) autograft, (iii) BMP2 + ACS, (iv) BMP2 + ACS + LLG and (v) BMP2 + HLG + ACS were examined in 9 mm × 12 mm defects performed bilaterally in the medial femoral condyles of 24 aged (>5 years) sheep. Bone formation within the defect was assessed using micro-computed tomography (micro-CT), digital volume correlation (DVC) for biomechanical characterisation as well as histology. The autograft and InductOs® mediated enhanced bone formation ( p < 0001) compared to blank controls, while no significant differences were observed between the Laponite/Collagen/BMP delivery vehicles. However, the current study illustrated the excellent biocompatibility of Laponite and its ability to deliver localised active BMP-2, with the opportunity for improved efficacy with further optimisation. Interestingly, DVC-computed strain distributions indicated that the regenerated bone structure is mechanically adapted to bear external loads from the early remodelling stages of the bone reparation cascade. The current studies of selected nanoclay delivery platforms for BMP, assessed in a clinically relevant large animal model auger well for the development of bone fracture therapeutics for an ageing population.

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Section: Discussionmentioning

confidence: 99%

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model

et al. 2022

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“…Different pipelines for the generation of microFE models of trabecular bone were proposed (Cox et al, 2022;Fernández et al, 2022;Megías et al, 2022;Stauber et al, 2004;Verhulp et al, 2008). Nevertheless, the validation and comparison of results across studies is hindered by the use of proprietary or non-open-source software, and by the general absence of reproducible FE pipelines.…”

Section: Statement Of Needmentioning

confidence: 99%

Ciclope: micro Computed Tomography to Finite Elements

Iori¹,

Crimi²,

Schileo³

et al. 2023

JOSS

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“…Further validation has been performed to validate microFE models of more complex structures such as vertebral bodies with ( Palanca et al, 2022 ) or without ( Costa et al, 2017 ) lesions, and the mouse tibia ( Oliviero et al, 2018 ). Recently, more complex models of trabecular bone with heterogeneous material properties ( Knowles et al, 2021 ) or material nonlinearities ( Pena Fernandez et al, 2022 ) have also been validated with DVC data. Finally, the DVC has also been used to validate the outputs of homogenised FE models based on clinical CT images including the human proximal femur ( Ridzwan et al, 2018 ), scapula ( Kusins et al, 2020a ), humeral head ( Kusins et al, 2020b ), and vertebrae ( Jackman et al, 2016 ).…”

Section: Digital Volume Correlation Approaches and Applicationsmentioning

confidence: 99%

Digital volume correlation for the characterization of musculoskeletal tissues: Current challenges and future developments

Dall’Ara

Tozzi

2022

Front. Bioeng. Biotechnol.

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Biological tissues are complex hierarchical materials, difficult to characterise due to the challenges associated to the separation of scale and heterogeneity of the mechanical properties at different dimensional levels.The Digital Volume Correlation approach is the only image-based experimental approach that can accurately measure internal strain field within biological tissues under complex loading scenarios. In this minireview examples of DVC applications to study the deformation of musculoskeletal tissues at different dimensional scales are reported, highlighting the potential and challenges of this relatively new technique.The manuscript aims at reporting the wide breath of DVC applications in the past 2 decades and discuss future perspective for this unique technique, including fast analysis, applications on soft tissues, high precision approaches, and clinical applications.

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Nonlinear micro finite element models based on digital volume correlation measurements predict early microdamage in newly formed bone

Cited by 14 publications

References 94 publications

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model

Ciclope: micro Computed Tomography to Finite Elements

Digital volume correlation for the characterization of musculoskeletal tissues: Current challenges and future developments

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Nonlinear micro finite element models based on digital volume correlation measurements predict early microdamage in newly formed bone

Cited by 14 publications

References 94 publications

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs®) in an ovine bone model

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs®) in an ovine bone model

Ciclope: micro Computed Tomography to Finite Elements

Digital volume correlation for the characterization of musculoskeletal tissues: Current challenges and future developments

Contact Info

Product

Resources

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Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model