Reservoir computing refers to a computational framework based on recurrent neural networks that can process time-series data. In an echo state network (ESN), which is a type of reservoir computing framework, the reservoir consists of a recursive network of artificial neurons with nonlinear activation functions. A model predictive control (MPC) technique can determine the control signals by solving the optimization problem of a system using the finite-time domain of each control period. However, real-time optimization cannot be achieved unless the optimal control problem can be solved within the next control period. To overcome this limitation, we propose a new control method based on MPC that explicitly incorporates the predicted disturbance of a time-varying trajectory using ESN to achieve the active vibration control of hybrid electric vehicle (HEV) powertrains. Once the ESN has been trained, the associated MPC explicitly satisfies the constraints over a moving horizon without further training. Instead of completing the real-time optimization within the control period, ESN predicts the future disturbance and applies it to the MPC in the future control period. Based on the predicted future disturbance, the system calculates the optimal control signals required for the future. Thus, real-time control can be realized because the optimal signals are determined before the subsequent control period occurs. The proposed method can be implemented in MPC even if the control period is too short to optimize as long as the disturbance can be reasonably measured and predicted. In this study, the simulation approach was demonstrated using the engine start condition in an HEV powertrain. The importance of this study is that the limitation of MPC relevant to real-time optimization can be relaxed by applying our proposed method.