In order to study the flow-induced vibration characteristics of the natural gas vent pipeline under the internal flow field, taking the gas transmission station pipeline as an example, the ANSYS Workbench software was used to establish models under two working conditions, uncoupling and fluid-solid coupling, for modal analysis, and analyze and compare the calculation results and propose a structural improvement plan. The results show that the maximum amplitude of the first three modes under the two working conditions is concentrated on the riser mouth, and the amplitude under the fluid-solid coupling condition is slightly larger than that of no coupling; the inner diameter of the pipe elbow is large and the pressure is small, and the outside diameter is small and the pressure is small. Large, this instability will increase the air pulsation of the flow field. In the improved scheme, adding a restriction on the top to increase the rigidity of the pipeline can significantly reduce the maximum amplitude of the gas pipeline; adding an orifice to eliminate air flow pulsation has a certain effect on reducing the maximum amplitude and natural frequency, and the combination of the two can make the pipeline more stable. The research results of this paper can provide improved ideas for vibration reduction at the natural gas venting operation site.