We study the Klein four-group (K 4 ) symmetry of the time-dependent Schrödinger equation for the conformal mechanics model of de Alfaro-Fubini-Furlan (AFF) with confining harmonic potential and coupling constant g = ν(ν + 1) ≥ −1/4. We show that it undergoes a complete or partial (at half-integer ν) breaking on eigenstates of the system, and is the automorphism of the osp(2, 2) superconformal symmetry in super-extensions of the model by inducing a transformation between the exact and spontaneously broken phases of N = 2 Poincaré supersymmetry. We exploit the K 4 symmetry and its relation with the conformal symmetry to construct the dual Darboux transformations which generate spectrally shifted pairs of the rationally deformed AFF models. Two distinct pairs of intertwining operators originated from Darboux duality allow us to construct complete sets of the spectrum generating ladder operators that identify specific finite-gap structure of a deformed system and generate three distinct related versions of nonlinearly deformed sl(2, R) algebra as its symmetry. We show that at half-integer ν, the Jordan states associated with confluent Darboux transformations enter the construction, and the spectrum of rationally deformed AFF systems undergoes structural changes.constant g = ν(ν + 1) ≥ −1/4 1 . Its non-relativistic conformal symmetry and supersymmetric extensions [5,6,7,8,9,10] find a variety of interesting applications including the particles dynamics in black hole backgrounds [11,12,13,14,15,16], cosmology [17,18,19], non-relativistic AdS/CFT correspondence [20,21,22,23,24], QCD confinement problem [25,26], and physics of Bose-Einstein condensates [27,28].On the other hand, the time-dependent Schrödinger equation for the AFF conformal mechanics model reveals a discrete Klein four-group symmetry generated by transformation of the parameter ν → −ν − 1, and by the spatial Wick rotation x → ix accompanied by the time reflection t → −t. In the picture of the stationary Schrödinger equation the time reflection transforms into the change of the eigenvalue's sign E → −E. The discrete symmetry K 4 , however, turns out to be completely broken at the level of the quantum states when ν is not a half-integer number : application of the group generators to physical eigenstates produces formal eigenstates which do not satisfy the necessary boundary conditions. In the case of half-integer values of the parameter ν the K 4 discrete symmetry breaks partially, and transformation ν → −ν − 1, as we shall see, turns out to be a true symmetry nontrivially realized on the spectrum of the system. In the physics of anyons, where the AFF model is used to generate the transmutation of statistics, halfinteger values of ν correspond to the two-particle system of identical fermions [29,30,31]. In the context of the problem we consider here, even though the new solutions with arbitrary value of ν generated by transformations of the discrete group are not acceptable from the physical point of view, the analogs of such non-physical states in other q...