Nonlocal shear-thinning effects substantially enhance helical propulsion

Demir, Ebru; Lordi, N. J.; Ding, Yanheng; Pak, On Shun

doi:10.1103/physrevfluids.5.111301

Cited by 15 publications

(14 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2017; Demir et al. 2020; Qu & Breuer 2020) swimmers can be enhanced significantly, all two-mode squirmers (pushers, pullers or neutral squirmers) swim slower in a shear-thinning fluid (Montenegro-Johnson et al. 2013; Datt et al.…”

Section: Introductionmentioning

confidence: 99%

The effect of particle geometry on squirming through a shear-thinning fluid

et al. 2022

Self Cite

View full text Add to dashboard Cite

Biological and artificial microswimmers often encounter fluid media with non-Newtonian rheological properties. In particular, many biological fluids such as blood and mucus are shear-thinning. Recent studies have demonstrated how shear-thinning rheology can impact substantially the propulsion performance in different manners. In this work, we examine the effect of geometrical shape upon locomotion in a shear-thinning fluid using a prolate spheroidal squirmer model. We use a combination of asymptotic analysis and numerical simulations to quantify how particle geometry impacts the speed and the energetic cost of swimming. The results demonstrate the advantages of spheroidal over spherical swimmers in terms of both swimming speed and energetic efficiency when squirming through a shear-thinning fluid. More generally, the findings suggest the possibility of tuning the swimmer geometry to better exploit non-Newtonian rheological behaviours for more effective locomotion in complex fluids.

show abstract

Section: Introductionmentioning

confidence: 99%

The effect of particle geometry on squirming through a shear-thinning fluid

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The physical insights and qualitative features obtained may be useful in interpreting results at higher Cu as suggested by recent studies. 50,52,54 At the actuated end (s = 1), the dimensionless boundary conditions for c andt are given by…”

Section: Non-dimensionalizationmentioning

confidence: 99%

“…A shear-thinning fluid loses its viscosity with increased shear rates due to changes in the fluid microstructure. Various theoretical and experimental models, including waving sheets, [48][49][50] squirmers, 51,52 rotating helices, 53,54 and nematodes, [55][56][57] among others, 51,[58][59][60] have revealed scenarios where the swimming speed can increase, decrease, or remain unchanged in a shear-thinning fluid relative to that in a Newtonian fluid. Although a wide variety of swimmer models considered in previous studies demonstrate the profound effects of shear-thinning rheology on locomotion, the shape and swimming gaits of these swimmers are prescribed and fixed.…”

Section: Introductionmentioning

confidence: 99%

Propulsion of an elastic filament in a shear-thinning fluid

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…A growing body of evidence indicates that ECM viscoelasticity influences fundamental cell processes such as differentiation, spreading, migration, and ECM synthesis, and plays a key role in the procession of diseases such as fibrosis and cancer [ 49 ]. Considering the growing body of literature on microscale self-propulsion in shear-thinning [ 113 , 114 , 115 ] and viscoelastic media [ 116 , 117 ], it is reasonable to expect that ECM viscoelasticity will influence the efficiency of the self-propulsion. Accordingly, to develop SPPs that are attractive for biomedical applications in drug delivery in human tissues, it is critical that the swimming performance of SPPs be tested in environments that possess similar viscoelastic characteristics to in vivo human tissues.…”

Section: Self-propelled Particles Movement In Ecmmentioning

confidence: 99%

Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices

Singh

Moran

2021

Micromachines

View full text Add to dashboard Cite

For effective treatment of diseases such as cancer or fibrosis, it is essential to deliver therapeutic agents such as drugs to the diseased tissue, but these diseased sites are surrounded by a dense network of fibers, cells, and proteins known as the extracellular matrix (ECM). The ECM forms a barrier between the diseased cells and blood circulation, the main route of administration of most drug delivery nanoparticles. Hence, a stiff ECM impedes drug delivery by limiting the transport of drugs to the diseased tissue. The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency. Here, we provide a comprehensive look at the current ECM models in use to mimic the in vivo diseased states, the different types of SPPs that have been experimentally tested in these models, and suggest directions for future research toward clinical translation of SPPs in diverse biomedical settings.

show abstract

Nonlocal shear-thinning effects substantially enhance helical propulsion

Cited by 15 publications

References 57 publications

The effect of particle geometry on squirming through a shear-thinning fluid

The effect of particle geometry on squirming through a shear-thinning fluid

Propulsion of an elastic filament in a shear-thinning fluid

Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices

Contact Info

Product

Resources

About