Nonmelanoma skin cancer in Japanese ethnic Hawaiians in Kauai, Hawaii: An incidence report

Chuang, Tsu‐Yi; Reizner, George T.; Elpern, David J.; Stone, Jill P.; Farmer, Evan R.

doi:10.1016/0190-9622(95)91387-4

Cited by 61 publications

(41 citation statements)

References 8 publications

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“…On the island of Kauai, in Hawaii, the incidence of non-melanoma skin cancer is 45 times higher in Japanese immigrants as compared to Japanese (in Japan) 7 . The predominance of farming in this immigrant community in Hawaii and proximity to the Equator (latitude 22°N) contribute to this high incidence 19,20 .…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil

et al. 2009

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Section: Discussionmentioning

confidence: 99%

“…A recent national survey by this society showed a higher prevalence of basal cell carcinoma in the Japanese population and a non-melanoma skin cancer incidence of 1.2 to 5.4 per 100 thousand inhabitants 5,6,7 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil

et al. 2009

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“…26 Despite the recent increase, the current BCC rates still have not surpassed the SCC rates in Japan. The unusual similarity in BCC and SCC incidence rates in Japanese has also been suggested by a study of NMSC 27 in the Japanese residents of Kauai, Hawaii, where the BCC rates are extremely high in other population groups. 28 The BCC rates of 29.7 per 10 5 in Japanese Kauai residents, though much higher than those in Japan, were only slightly higher than the SCC rates of 22.9.…”

mentioning

confidence: 90%

“…28 The BCC rates of 29.7 per 10 5 in Japanese Kauai residents, though much higher than those in Japan, were only slightly higher than the SCC rates of 22.9. 27 The pigmented skin in Japanese may be more resistant than fair Caucasian skin against intense and intermittent sun exposures. There is, however, considerable variability in skin color and sun sensitivity among Japanese.…”

mentioning

confidence: 99%

Histologic characteristics of skin cancer in Hiroshima and Nagasaki: Background incidence and radiation effects

Kishikawa¹,

Koyama

Iseki

et al. 2005

Intl Journal of Cancer

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Skin cancers, though rare in Japan, have reportedly been on the rise, but little else is known about epidemiologic features of different histologic types of skin cancer. The Life Span Study cohort, which consists of 93,700 atomic-bomb survivors, many of whom were exposed to negligibly low radiation doses, and 26,600 people not exposed to radiation, enables a population-based study of spontaneous as well as radiation-related cancer risk. Skin tumor incident cases diagnosed between 1958 and 1987 were ascertained by linkage to the Hiroshima and Nagasaki tumor registries augmented by searches of other data sources. Study pathologists reviewed tumor specimens and pathology reports and classified tumors using the World Health Organization classification scheme. They identified 274 primary incident skin cancers, of which 106 were basal cell carcinoma (BCC), 81 were squamous cell carcinoma (SCC), and 14 were malignant melanomas. Background incidence rates and radiation effects were assessed by Poisson regression models allowing for the effects of demographic and other covariates. BCC and SCC background incidence rates were both about 3 per 100,000 per year. BCCs were mainly on the head/neck (81%), whereas SCCs occurred most frequently on the arms/legs (45%) and head/neck (29%), consistent with the presumed role played by solar UV exposure in skin cancer. The BCC rates increased significantly between 1958 and 1987, whereas the SCC rates remained unchanged. The excess absolute risk of BCC per unit skin surface area related to atomic-bomb radiation exposure did not differ between UV-exposed and shielded parts of the body, suggesting the additivity of the radiation-related and background BCC risks. ' 2005 Wiley-Liss, Inc.Key words: basal cell carcinoma of the skin; squamous cell carcinoma of the skin; ionizing radiation; sun exposure Skin cancers are relatively rare in Japan. Age-adjusted incidence rates (per 10 5 per year) of melanoma are 0.2-0.5 in Japan compared to that of 10-20 in US whites and 30-40 in Australia. 1The incidence rates of about 1.0-5.5 for NMSC in Japan are much lower than US white rates of about 250.1,2 UV radiation is the major cause of skin cancer, involving all 3 major types: BCC, SCC and melanoma in fair-skinned Caucasian populations. 3,4 Except for the reportedly rising incidence of melanoma and BCC of the skin, 5,6 there have been little epidemiologic data on characteristics of skin cancer in Japan, especially by histologic types.IR has long been known to cause skin cancer, especially BCC, 3,4,7 and we previously reported the IR effect on BCC in the LSS cohort of atomic bomb survivors and controls.8 A large number of subjects (more than 57,000 or 51%) in this cohort were not or were only negligibly exposed (i.e., at <5 mSv) to radiation from the atomic bombs. This enabled us to analyze the background cancer rates by histologic type, taking advantage of the long-term cancer incidence follow-up.In our study, we describe the epidemiologic characteristics of background rates for the different histolog...

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“…Bowen's disease occurs mainly in sun-exposed skin areas (Thestrup-Pedersen et al, 1988;Kossard and Rosen, l992) and is possibly caused by ultraviolet light (Reizner et al, 1994;Chuang et al, 1995), or on the lower extremities (Cox, 1994). A number of studies have demonstrated relatively high incidence of human papilloma virus (HPV) in Bowen's disease affecting the genital region (38-80%) and other skin regions (19.4-40%), by using Southern blot analysis with HPVl6 DNA (Ikenberg et al, 1983), immunohistochemical staining for viral antigens (Grussendorf-Conen and Giesen, l990), and in situ hybridization (ISH) (Kettler et al, 1990).…”

Section: Preserved Normal Basal Cell Layer In Bowen' Disease (Ishida mentioning

confidence: 99%

The DNA-instability test as a specific marker of malignancy and its application to detect cancer clones in borderline malignancy

Fukuda¹,

Sun²

2009

Eur J Histochem

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Recent progress in cytogenetic and biochemical mutator assay technologies has enabled us to detect single gene alterations and gross chromosomal rearrangements, and it became clear that all cancer cells are genetically unstable. In order to detect the genome-wide instability of cancer cells, a new simple method, the DNA-instability test, was developed. The methods to detect genomic instability so far reported have only demonstrated the presence of qualitative and quantitative alterations in certain specific genomic loci. In contrast to these commonly used methods to reveal the genomic instability at certain specific DNA regions, the newly introduced DNA-instability test revealed the presence of physical DNA-instability in the entire DNA molecule of a cancer cell nucleus as revealed by increased liability to denature upon HCl hydrolysis or formamide exposure. When this test was applied to borderline malignancies, cancer clones were detected in all cases at an early-stage of cancer progression. We proposed a new concept of "procancer" clones to define those cancer clones with "functional atypia" showing positivities for various cancer markers, as well as DNA-instability testing, but showing no remarkable ordinary "morphological atypia" which is commonly used as the basis of histopathological diagnosis of malignancy.

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Nonmelanoma skin cancer in Japanese ethnic Hawaiians in Kauai, Hawaii: An incidence report

Cited by 61 publications

References 8 publications

Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil

Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil

Histologic characteristics of skin cancer in Hiroshima and Nagasaki: Background incidence and radiation effects

The DNA-instability test as a specific marker of malignancy and its application to detect cancer clones in borderline malignancy

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