Nonmelanoma Skin Cancer in Survivors of Childhood and Adolescent Cancer: A Report From the Childhood Cancer Survivor Study

Perkins, Jack; Liu, Yan; Mitby, Pauline; Neglia, Joseph P.; Hammond, Sue; Stovall, Marilyn; Meadows, Anna T.; Hutchinson, Ray; Dreyer, Zo Ann E.; Robison, Leslie L.; Mertens, Ann C.

doi:10.1200/jco.2005.06.237

Cited by 150 publications

(110 citation statements)

References 31 publications

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“…47 Although development of an NMSC within the RT field is a recognized risk, it portends increased tissue sensitivity to RT. Therefore, the decreased risk of overall mortality in cohort members who developed an NMSC was unexpected.…”

Section: Discussionmentioning

confidence: 99%

Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study

Castellino¹,

Geiger

Mertens

et al. 2011

Blood

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311

217

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The contribution of specific cancer therapies, comorbid medical conditions, and host factors to mortality risk after pediatric Hodgkin lymphoma (HL) is unclear. We assessed leading morbidities, overall and cause-specific mortality, and mortality risks among 2742 survivors of HL in the Childhood Cancer Survivor Study, a multi-institutional retrospective cohort study of survivors diagnosed from 1970 to 1986. Excess absolute risk for leading causes of death and cumulative incidence and standardized incidence ratios of key medical morbidities were calculated. Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of risks for overall and cause-specific mortality. Substantial excess absolute risk of mortality per 10 000 person-years was identified: overall 95.5; death due to HL 38.3, second malignant neoplasms 23.9, and cardiovascular disease 13.1. Risks for overall mortality included radiation dose > 3000 rad (

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Section: Discussionmentioning

confidence: 99%

Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study

Castellino¹,

Geiger

Mertens

et al. 2011

Blood

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311

217

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“…10 In addition, survivors treated with ionizing radiation are at increased risk for nonmelanoma skin cancers, leaving additional scarring or disfigurement. 3 Available data on the prevalence of these outcomes among adult childhood cancer survivors are limited. A small single-site study of dermatologic…”

Section: -9mentioning

confidence: 99%

Scarring, Disfigurement, and Quality of Life in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Kinahan

Sharp

Seidel

et al. 2012

JCO

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119

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A B S T R A C T PurposeChildhood cancer survivors are at increased risk for adverse outcomes and chronic medical conditions. Treatment-related scarring, disfigurement, and persistent hair loss, in addition to their long-term impact on psychological distress or health-related quality of life (HRQOL), have received little attention. Patients and MethodsSelf-reported scarring/disfigurement and persistent hair loss were examined in 14,358 survivors and 4,023 siblings from the Childhood Cancer Survivor Study. Multivariable models were used to examine associations with demographic and cancer treatment. The impact of disfigurement and hair loss on HRQOL (ie, Medical Outcomes Short Form-36) and emotional distress (ie, Brief Symptom Inventory-18) was examined. ResultsSurvivors reported a significantly higher rate of scarring/disfigurement compared with siblings for head/neck (25.1% v 8.4%), arms/legs (18.2% v 10.2%), and chest/abdomen (38.1% v 9.1%), as well as hair loss (14.0% v 6.3%). In age-, sex-, and race-adjusted models, cranial radiation exposure Ն 36 Gy increased risk for head/neck disfigurement (relative risk [RR], 2.42; 95% CI, 2.22 to 2.65) and hair loss (RR, 4.24; 95% CI, 3.63 to 4.95). Adjusting for cranial radiation, age, sex, race, education, and marital status, survivor hair loss increased risk of anxiety (RR, 1.60; 95% CI, 1.23 to 2.07), whereas head/neck disfigurement increased risk of depression (RR, 1.19; 95% CI, 1.01 to 1.41). Limitations due to emotional symptoms were associated with head/neck disfigurement (RR, 1.24; 95% CI, 1.10 to 1.41), arm/leg disfigurement (RR, 1.19; 95% CI, 1.05 to 1.35), and hair loss (RR, 1.26; 95% CI, 1.09 to 1.47). ConclusionSurvivors of childhood cancer are at increased risk for disfigurement and persistent hair loss, which is associated with future emotional distress and reduced quality of life. Future studies are needed to better identify and manage functional outcomes in these patients.

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“…Nonmalignant neoplasms, such as meningiomas, and nonmelanoma skin cancers are also ascertained in several cohort studies through the mechanisms described above (9,84,86). However, because these SPNs are not included in the population-based cancer registries, the SIR and the absolute excess risk (AER) for these outcomes cannot be determined.…”

Section: Subsequent Primary Neoplasmsmentioning

confidence: 99%

Methods to Assess Adverse Health-Related Outcomes in Cancer Survivors

Oeffinger

Leeuwen

Hodgson

2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Designing a study focused on adverse health-related outcomes among cancer survivors is complex. Similarly, reading and interpreting the findings of a survivorship-focused study requires an appreciation of the complexities of study design, potential biases, confounding factors, and other limitations. The topic areas are broad-study design, comparison populations, measures of risk, key health outcomes of interest, potential modifying factors to consider. With brevity, this article includes basic information to consider within these areas as well as examples and concepts intended to advance the science of survivorship research and encourage further reading and exploration. Cancer Epidemiol Biomarkers Prev; 20(10); 2022-34. Ó2011 AACR.

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Nonmelanoma Skin Cancer in Survivors of Childhood and Adolescent Cancer: A Report From the Childhood Cancer Survivor Study

Abstract: Long-term survivors of childhood and adolescent cancer who were treated with RT are at highest risk for developing NMSC. Educational efforts need to be directed to this population to facilitate early diagnosis of NMSC and reduction in sun exposure.

Cited by 150 publications

References 31 publications

Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study

Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study

Scarring, Disfigurement, and Quality of Life in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Methods to Assess Adverse Health-Related Outcomes in Cancer Survivors

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