2021
DOI: 10.5897/ajpp2021.5236
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NONMEM population pharmacokinetic and Monte Carlo dosing simulation of ertapenem in patients with sepsis

Abstract: An alteration of pharmacokinetics (PK) due to pathophysiological changes in patients with critical illnesses have the impact on the drug levels in plasma, consequently affecting the achievement of pharmacodynamics (PD) targets of antibiotics. The objectives of this study were (i) to determine the population PK, and (ii) to assess the probability of target attainment (PTA) of ertapenem in patients with critical conditions. The study examined the population PK of ertapenem using NONMEM and performed the assessme… Show more

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