Nonmotor Disturbances in Parkinson’s Disease

Bassetti, Claudio L.

doi:10.1159/000316613

Cited by 48 publications

(26 citation statements)

References 247 publications

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“…Orthostatic hypotension or postural hypotension is another common non-motor symptom. The prevalence is between 20 and 50% [42,43]. Orthostatic hypotension has been previously reported to be associated with falls in persons with PD [44,45].…”

Section: Discussionmentioning

confidence: 99%

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

Bryant

Rintala²,

Hou

et al. 2012

Eur Neurol

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Objective: To characterize non-motor symptoms in individuals with Parkinson’s disease (PD) who experience falls compared to those who do not fall. Methods: Fifty-four individuals with PD were studied. Thirty-six were fallers and 18 were non-fallers. Fatigue was assessed by the Iowa Fatigue Scale. Excessive daytime sleepiness was assessed by the Epworth Sleepiness Scale, and depressive symptomatology was assessed by the short-form Center for Epidemiologic Studies Depression Scale. Results: Compared to non-fallers, fallers had more severe disability, greater general physical fatigue (p = 0.024), lower energy levels (p = 0.042) and less productivity (p = 0.007). Fallers had more depressive symptomatology than the non-fallers (p = 0.01). Excessive daytime sleepiness was not different between the two groups (p = 0.695). Conclusions: Individuals with PD who fell had more severe motor and non-motor symptoms than those who did not fall. These non-motor symptoms included physical fatigue, energy, productivity and depressive symptomatology.

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Section: Discussionmentioning

confidence: 99%

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

Bryant

Rintala²,

Hou

et al. 2012

Eur Neurol

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“…Interestingly, an estimated proportion of 90 % of PD patients exhibit olfactory deficits [89–91]. Several studies detected olfactory deficits early in the course of the disease, before the appearance of motor symptoms (for review, see [92]).…”

Section: Spread Of Synucleinopathy and Progression Of Parkinson’s Dismentioning

confidence: 99%

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

et al. 2012

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Parkinson’s disease patients exhibit progressive spreading of aggregated α-synuclein in the nervous system. This slow process follows a specific pattern in an inflamed tissue environment. Recent research suggests that prion-like mechanisms contribute to the propagation of α-synuclein pathology. Little is known about factors that might affect the prion-like behavior of misfolded α-synuclein. In this review, we suggest that neuroinflammation plays an important role. We discuss causes of inflammation in the olfactory bulb and gastrointestinal tract and how this may promote the initial misfolding and aggregation of α-synuclein, which might set in motion events that lead to Parkinson's disease neuropathology. We propose that neuroinflammation promotes the prion-like behavior of α-synuclein and that novel anti-inflammatory therapies targeting this mechanism could slow disease progression.

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“…Several of these NMS were described in James Parkinson’s original essay. They can include sleep disturbances, neuropsychiatric and cognitive deficits, and autonomic and sensory dysfunction (Bassetti, 2011; Chaudhuri et al, 2011). Further highlighting their importance, retrospective studies showed that some NMS, can appear several years before the onset of the classical motor signs (Abbott et al, 2005, 2007; Ross et al, 2006).…”

Section: An Updated View Of An Old Mystery: the Non-motor Symptoms Ofmentioning

confidence: 99%

Animal models of the non-motor features of Parkinson's disease

McDowell¹,

Chesselet²

2012

Neurobiology of Disease

141

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The non-motor symptoms (NMS) of Parkinson’s disease (PD) occur in roughly 90% of patients, have a profound negative impact on their quality of life, and often go undiagnosed. NMS typically involve many functional systems, and include sleep disturbances, neuropsychiatric and cognitive deficits, and autonomic and sensory dysfunction. The development and use of animal models have provided valuable insight into the classical motor symptoms of PD over the past few decades. Toxin-induced models provide a suitable approach to study aspects of the disease that derive from the loss of nigrostriatal dopaminergic neurons, a cardinal feature of PD. This also includes some NMS, primarily cognitive dysfunction. However, several NMS poorly respond to dopaminergic treatments, suggesting that they may be due to other pathologies. Recently developed genetic models of PD are providing new ways to model these NMS and identify their mechanisms. This review summarizes the current available literature on the ability of both toxin-induced and genetically-based animal models to reproduce the NMS of PD.

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Nonmotor Disturbances in Parkinson’s Disease

Cited by 48 publications

References 247 publications

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

Animal models of the non-motor features of Parkinson's disease

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