Nonmotor symptoms in patients with Parkinson disease

Zhang, Tie-Mei; Yu, Shuyang; Guo, Ping; Du, Yang; Hu, Yang; Piao, Ying-shan; Zuo, Lijun; Lian, Ting; Wang, Ruidan; Yu, Qing; Jin, Zhao; Zhang, Wei

doi:10.1097/md.0000000000005400

Cited by 61 publications

(51 citation statements)

References 23 publications

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“…Patients with PD often show notable body movements and features such as tremor in hand or foot, limbs rigidity, postural instability, insomnia, rapid eye movement sleep behavior disorder and motor impairment [14][15][16][17]. There is currently no cure for PD.…”

Section: Sift Deskmentioning

confidence: 99%

The Roles of Melatonin in Parkinson’s Disease: An Overview

Moi¹,

Lim²,

Koh³

et al. 2017

SDRP-JCMP

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When the central nervous system loses its nerve cell functions over a period of time, symptoms and problems arise leading to the progression of neurodegenerative diseases. Statistical data shows that more than 5 million people worldwide are affected by Parkinson's disease [PD], and the data is undesirably rising every year. In PD patients, structural and functional changes are shown in the brain, especially the substantia nigra region. The underlying cause that correspond to the development of PD remains unclear. Nevertheless, α-synuclein aggregation has been reported to be neuropathologically linked to PD. On the other hand, several evidences successfully demonstrate the importance and significance of mitochondrial dysfunction in PD models. Treatments available for PD are limited. Recently, as shown in some studies, the antioxidant properties and hypnotic benefits of melatonin bring remarkable contribution to the PD patients. Hence, in this article, we focus on the effect of melatonin associating with the pathology and physiology of PD.

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Section: Sift Deskmentioning

confidence: 99%

The Roles of Melatonin in Parkinson’s Disease: An Overview

Moi¹,

Lim²,

Koh³

et al. 2017

SDRP-JCMP

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“…Parkinson's disease represents a major medical concern for health professionals, national healthcare bodies and a heavy burden for caregivers (Nance, 2015 andCruickshank et al, 2015). It greatly affects the quality of life of patients (Zhang et al, 2016). Incidence of PD disease is approximately 1.8 times higher in men versus women (1.5-2.0) (Hirtz et al 2007;Mhyre, et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Incidence of PD disease is approximately 1.8 times higher in men versus women (1.5-2.0) (Hirtz et al 2007;Mhyre, et al, 2012). The study of Zhang et al, 2016 revealed that the incidence of PD is slightly higher in males than in females; the ratio was close to 1:1, the average age of PD patients was about 60 years, the education level of patients with PD was paralleled with that of age-matched (40-70 years old) (Ransmayr, 2015), and education is not an associated factor for PD. The socioeconomic burden of PD is great with estimates of both direct and indirect costs upward of about $23 billion every year in the US (Huse et al 2005;Mhyre, et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Autonomic dysfunctions include the deregulations of sweat gland, body temperature, cardiovascular, gastrointestinal, and genitourinary systems, mainly relevant to appearance of Lewy bodies in sympathetic or parasympathetic cholinergic ganglion, and sympathetic adrenergic nerve ganglion. The Autonomic disorder, leads to major problems such as constipation, frequent urination at night, orthostatic hypotension, fatigue, polyhidrosis, and sexual dysfunction (Truong et al, 2008;Zhang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Parkinson Disease, is characterized by four major motor symptoms (MS) including resting tremor, bradykinesia, rigidity, and postural and gait instability, and numerous nonmotor symptoms (NMS), such as neuropsychiatric symptoms, sleep disorders, autonomic dysfunctions, and sensory disturbances (Zhang et al, 2016). Autonomic dysfunctions include the deregulations of sweat gland, body temperature, cardiovascular, gastrointestinal, and genitourinary systems, mainly relevant to appearance of Lewy bodies in sympathetic or parasympathetic cholinergic ganglion, and sympathetic adrenergic nerve ganglion.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Parkinson Disease in Hospitalized Patients With Congestive Heart Failure

Enwerem¹,

Okunji²,

Ngwa³

et al. 2018

IJSN

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Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, after Alzheimer's disease, affecting approximately one million persons aged 65 years and above in the United States. Parkinson's disease represents a major medical concern for health professionals, national healthcare bodies and a heavy burden for caregivers. Heart failure occurred twice as frequently in elderly PD patients as in non-PD patients. There is paucity of information on the association of patient and hospital characteristics on the outcomes of inpatient with both congestive heart failure and Parkinson disease.Congestive Heart Failure with PD as a comorbidity will increase the cost of care and health resources. We investigate on the current prevalence and factors that affect the inpatient with both CHF and PD conditions using a longitudinal datasets from National Inpatient Samples. The results obtained from this study will provide information that will reduce frequent readmission, length of stay, total charges and mortality rate in this population.Methods: Data from the National Inpatient Samples (NIS) were extracted and analyzed using ICD 9 codes (CHF 428, PD 332) for the main diagnosis. For continuous variables, we calculated the mean and standard deviations and evaluated significant differences of these factors by Parkinson disease status using the t-test. For categorical variables, we obtained the counts (proportions) and evaluated significant differences using the Chi-square and Fisher's exact test Propensity score was utilized to match age, gender and race using logistic model for hospital death and generalized linear model for length of stay (LOS) and hospital charges.Result: The overall frequency of Parkinson disease (PD) in congestive heart failure was 1.54 % (n = 10,748). PD patients with CHF were more likely to be males (53.13 %; 5462) and Caucasians (82.24 %; n=8454). The average age of inpatient was approximately 80 years (SD=8.05). Hospital admission, decreases with median household income. Patients with low income ($1 -$38,999) were admitted more with 3002 (29.70%) than those with higher income ($63,000 and more) with 2230 (22.06%). Length of stay (LOS) (p<0.0001) and total charge incurred during hospitalization were less in patients with PD (p< 0.005) (table 1). In these analyses, we found that patients with PD were discharged more from urban non-teaching hospital than urban teaching hospital (p<0.0001).Conclusion: The general characteristics and frequency of the participant in this study are summarized in Table I. Accordingly, characteristics of patients with congestive heart failure with or without Parkinson's disease did not differ by age, gender, or ethnicity (P>1.000). Similarly, hospital death rates (%) were not different (P>1.000), although hospital length of stay (P<1.000) and total charge incurred during hospitalization were less in patients with PD (p < 0.005)

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Autonomic Dysfunction in Parasomnias of REM Sleep

Zitser

Miglis

2021

Autonomic Nervous System and Sleep

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Nonmotor symptoms in patients with Parkinson disease

Cited by 61 publications

References 23 publications

The Roles of Melatonin in Parkinson’s Disease: An Overview

The Roles of Melatonin in Parkinson’s Disease: An Overview

Prevalence of Parkinson Disease in Hospitalized Patients With Congestive Heart Failure

Autonomic Dysfunction in Parasomnias of REM Sleep

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