Nonmulberry silk-based biomaterials: biomedical applications, current status, and future perspective

Jaiswal, Chitra; Dey, Souradeep; Shome, Sayanti; Mandal, Gargi; Bhat, Amritha K.; Khatua, Rupam; Mishra, Animesh; Ghibhela, Baishali; Das, Eshani; More, Shruti; Mandal, Biman B.

doi:10.1016/b978-0-323-96017-5.00015-7

Cited by 2 publications

(1 citation statement)

References 159 publications

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“…SF as a biopolymer is attributed with properties like biocompatibility, immunocompatibility, mechanical resiliency, easy processability and affordability [47,48,52,55,75]. In comparison to other biopolymers, silkworm silk is produced in tonnes per year and the extraction of silk fibroin from the cocoons or silk glands are comparatively easy and cost-effective [76,77].…”

Section: Silk As a Biomaterialsmentioning

confidence: 99%

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Singh,

Bandyopadhyay,

Dey

et al. 2024

Prog. Biomed. Eng.

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Cartilage repair remains a significant clinical challenge in orthopedics due to its limited self- regeneration potential and often progresses to osteoarthritis which reduces the quality of life. 3D printing/bioprinting has received vast attention in biofabrication of functional tissue substitutes due to its ability to develop complex structures such as zonally structured cartilage and osteochondral tissue as per patient specifications with precise biomimetic control. Towards a suitable bioink development for 3D printing/bioprinting, silk fibroin has garnered much attention due to its advantageous characteristics such as shear thinning behavior, cytocompatibility, good printability, structural fidelity, affordability, and ease of availability and processing. This review attempts to provide an overview of current trends/strategies and recent advancements in utilizing silk-based bioinks/biomaterial-inks for cartilage bioprinting. Herein, the development of silk-based bioinks/biomaterial-inks, its components and the associated challenges, along with different bioprinting techniques have been elaborated and reviewed. Furthermore, the applications of silk-based bioinks/biomaterial-inks in cartilage repair followed by challenges and future directions are discussed towards its clinical translations and production of next-generation biological implants.

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Section: Silk As a Biomaterialsmentioning

confidence: 99%

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Singh,

Bandyopadhyay,

Dey

et al. 2024

Prog. Biomed. Eng.

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Non-mulberry silk fibroin functionalization enhances charge-transfer efficiency in aligned polypyrrole-silk composites for electrically stimulated neurite outgrowth

Borah,

Moses,

Upadhyay

et al. 2024

Preprint

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Electroconductive biomaterials (ECBs) replicate the natural bioelectrical environment of nerve tissue, promoting action potential propagation after injury and enhancing nerve regeneration through therapeutic electrical stimulation (ES). We present a highly electroactive Faradaic ECB with exceptional electrical conductivity and charge density, alongside low electrochemical impedance. These ECBs trigger action potentials at low stimulation voltages by regulating redox reactions through their intrinsic reversible behavior, thereby preventing electrode degradation and tissue damage. Our biohybrid scaffold consists of aligned microfibrous matrices of polypyrrole (PPy) andBombyx morisilk fibroin (BmSF), functionalized withAntheraea assamensissilk fibroin (AaSF) rich in the cell-affinitive RGD tripeptide. Serving as an anionic dopant for PPy, AaSF significantly enhances the scaffold’s electrical properties (∼9.18 mS cm-1) and charge-transfer efficiency (∼25.27 Ω). The scaffolds exhibit superior charge injection capacity at low potentials compared to conventional bioelectrodes (e.g., 0.46 mC cm-2at 50 mV). Under pulsed ES at 50 mV cm-1, these scaffolds support remarkable neurite outgrowth of dorsal root ganglion (DRG) neurons up to 830 μm (7 days). Notably, higher current densities and voltages decrease the rate of neurite outgrowth, highlighting the importance of optimizing ES parameters to effectively evoke functional action potentials without causing any neuronal damage. Biocompatibility assessments reveal that AaSF functionalization improves cellular behavior while minimizing immunomodulatory responses. Enhanced neuronal and glial differentiation is attributed to better cell communication facilitated by excellent adhesion and increased conductivity. In essence, this study provides a strategy for selecting optimal ES parameters for electrically excitable tissues using established electrochemical techniques. The fabricated biohybrid scaffolds hold significant promise as smart nerve guidance channels (NGCs) for future nerve regeneration therapies.

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Nonmulberry silk-based biomaterials: biomedical applications, current status, and future perspective

Cited by 2 publications

References 159 publications

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Non-mulberry silk fibroin functionalization enhances charge-transfer efficiency in aligned polypyrrole-silk composites for electrically stimulated neurite outgrowth

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