Nonneuronal roles for the reelin signaling pathway

Khialeeva, Elvira; Carpenter, Ellen M.

doi:10.1002/dvdy.24462

Cited by 33 publications

(28 citation statements)

References 108 publications

(177 reference statements)

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“…As it occurs in AML and CLL, the microenvironment participates in the acquisition of metabolic changes, through the action of specific adhesion proteins. In MM, Reelin, a glycoprotein found on extracellular matrix, whose action is linked to cell proliferation and migration during development and in cancer [117], has been shown to stimulate mTOR signaling, which in turn increases glycolysis through the HIF1α upregulation [118]. mTOR signaling can also be inactivated in MM by targeting metabolic pathways that have been less studied, even though they are crucial in the energetic cellular balance, such as nicotinamide adenine dinucleotide (NAD) biosynthesis.…”

Section: Multiple Myelomamentioning

confidence: 99%

mTOR Regulation of Metabolism in Hematologic Malignancies

Mirabilii

Ricciardi

Tafuri

2020

Cells

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Neoplastic cells rewire their metabolism, acquiring a selective advantage over normal cells and a protection from therapeutic agents. The mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase involved in a variety of cellular activities, including the control of metabolic processes. mTOR is hyperactivated in a large number of tumor types, and among them, in many hematologic malignancies. In this article, we summarized the evidence from the literature that describes a central role for mTOR in the acquisition of new metabolic phenotypes for different hematologic malignancies, in concert with other metabolic modulators (AMPK, HIF1α) and microenvironmental stimuli, and shows how these features can be targeted for therapeutic purposes.

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Section: Multiple Myelomamentioning

confidence: 99%

mTOR Regulation of Metabolism in Hematologic Malignancies

Mirabilii

Ricciardi

Tafuri

2020

Cells

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“…Another future aspect of the biology of ApoER2 and VLDLR is the Reelin pathway itself. Advances in the field of nonneuronal Reelin signaling suggest that this pathway might also be involved in the development of other organs as well as recently reviewed [ 171 ].…”

Section: Discussionmentioning

confidence: 99%

The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

Dlugosz

Nimpf

2018

IJMS

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Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with other adapter proteins to perform as signal transduction receptors. The best characterized signaling pathway in which ApoER2 and VLDL receptor (VLDLR) are involved is the Reelin pathway. This pathway plays a pivotal role in the development of laminated structures of the brain and in synaptic plasticity of the adult brain. Since Reelin and apolipoprotein E, are ligands of ApoER2 and VLDLR, these receptors are of interest with respect to Alzheimer’s disease. We will focus this review on the complex structure of ApoER2 and VLDLR and a recently characterized ligand, namely clusterin.

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“…Opto-Dab1 may also be useful to study Reelin-Dab1 signaling in synaptic plasticity140, in the development of non-neuronal tissues, such as mammary gland, small intestine and limbs, and in diseases including cancer414243. These applications will require the development of techniques to express opto-Dab1 effectively in the target cell types and to direct light to the respective tissues.…”

Section: Discussionmentioning

confidence: 99%

Optogenetic control of the Dab1 signaling pathway

Wang

Cooper

2017

Sci Rep

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The Reelin-Dab1 signaling pathway regulates development of the mammalian brain, including neuron migrations in various brain regions, as well as learning and memory in adults. Extracellular Reelin binds to cell surface receptors and activates phosphorylation of the intracellular Dab1 protein. Dab1 is required for most effects of Reelin, but Dab1-independent pathways may contribute. Here we developed a single-component, photoactivatable Dab1 (opto-Dab1) by using the blue light-sensitive dimerization/oligomerization property of A. thaliana Cryptochrome 2 (Cry2). Opto-Dab1 can activate downstream signals rapidly, locally, and reversibly upon blue light illumination. The high spatiotemporal resolution of the opto-Dab1 probe also allows us to control membrane protrusion, retraction and ruffling by local illumination in both COS7 cells and in primary neurons. This shows that Dab1 activation is sufficient to orient cell movement in the absence of other signals. Opto-Dab1 may be useful to study the biological functions of the Reelin-Dab1 signaling pathway both in vitro and in vivo.

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Nonneuronal roles for the reelin signaling pathway

Cited by 33 publications

References 108 publications

mTOR Regulation of Metabolism in Hematologic Malignancies

mTOR Regulation of Metabolism in Hematologic Malignancies

The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

Optogenetic control of the Dab1 signaling pathway

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