Nonnuclear Effects of the Steroid Hormone 1α,25(OH)2-Vitamin D3: Analogs Are Able to Functionally Differentiate Between Nuclear and Membrane Receptors

Dormanen, Murray C.; Bishop, June E.; Hammond, Marion W.; Okamura, William H.; Nemere, Ilka; Norman, A. W.

doi:10.1006/bbrc.1994.1714

Cited by 61 publications

(22 citation statements)

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“…(23) However, matrix vesicles are relatively small organelles, having diameters of 20 -50 nm, and they contain primarily plasma membrane enzymes and matrix metalloproteinases. (14,21,39,(41)(42)(43) Moreover, analogs that exhibit almost no binding to the VDR elicit responses identical to those caused by 1,25(OH) 2 D 3 , (25,26,44) providing strong evidence that if the VDR is present, the amounts would be so small as to be insignificant in the present context. Scatchard analysis indicates that matrix vesicles produced by both cell types have membrane receptors for 1,25-(OH) 2 D 3 .…”

Section: Discussionmentioning

confidence: 65%

Identification of a Membrane Receptor for 1,25-Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C

Nemere

Schwartz

Pedrozo

et al. 1998

Journal of Bone and Mineral Research

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207

110

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Section: Discussionmentioning

confidence: 65%

Identification of a Membrane Receptor for 1,25-Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C

Nemere

Schwartz

Pedrozo

et al. 1998

Journal of Bone and Mineral Research

Self Cite

207

110

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“…The conformation state of DHVD3 is 6- s -trans, which causes it to associate mainly with nVDR31. In contrast, the 6- s -cis conformation of DHVD3 and a 6- s -cis locked derivative of DHVD3, 1α,25-dyhydroxylumisterol, stimulated a rapid response32. Because the core structure of diosgenin is similar to that of the derivative 1α,25-dyhydroxylumisterol, we focused on the possibility that 1,25D 3 -MARRS might mediate the diosgenin signal as a cell surface receptor.…”

Section: Resultsmentioning

confidence: 98%

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

Tohda

Urano

Umezaki

et al. 2012

Sci Rep

147

152

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The aim of this study was to investigate the effects and the mechanism of diosgenin, a famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) model mice. Diosgenin-treated 5XFAD mice exhibited significantly improved performance of object recognition memory. Diosgenin treatment significantly reduced amyloid plaques and neurofibrillary tangles in the cerebral cortex and hippocampus. Degenerated axons and presynaptic terminals that were only observed in regions closely associated with amyloid plaques were significantly reduced by diosgenin treatment. The 1,25D3-membrane-associated, rapid response steroid-binding protein (1,25D3-MARRS) was shown to be a target of diosgenin. 1,25D3-MARRS knockdown completely inhibited diosgenin-induced axonal growth in cortical neurons. Treatment with a neutralizing antibody against 1,25D3-MARRS diminished the axonal regeneration effect of diosgenin in Aβ(1–42)-induced axonal atrophy. This is the first study to demonstrate that the exogenous stimulator diosgenin activates the 1,25D3-MARRS pathway, which may be a very critical signaling target for anti-AD therapy.

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“…Two proteins have been implicated in expression-independent vitamin D action: membrane VDR and the membrane-associated rapid response steroid binding (1,25D 3 -MARRS) protein. The evidence for the existence of a vitamin D membrane receptor came from two observations: first, the existence of vitamin D analogues that can cause rapid actions of vitamin D, but show low levels of affinity to the VDR [6,7]; and second, the existence of a vitamin D binding protein that has been described in the basolateral membrane of rat and chick enterocytes [8]. Besides the role of 1,25D 3 -MARRS as a vitamin D binding protein, the VDR can mediate non-transcriptional effects [5].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and the mammary gland: a review on its role in normal development and breast cancer

et al. 2012

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Breast cancer is a heterogeneous disease associated with diverse biological behaviours and clinical outcome. Although some molecular subgroups of breast cancer have a targeted therapy, the most aggressive tumours still lack a molecular target. Despite vitamin D being classically associated with the physiological role of calcium regulation and phosphate transport in bone metabolism, several studies have demonstrated a wide range of functions for this hormone, which are particularly important in the field of cancer. The mechanisms underlying the protective actions of vitamin D in cancer development are only sparsely understood, but evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell differentiation. In addition, it has been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis. Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1. In the present review we highlight research data concerning the function of this hormone in the mammary gland, with a special focus on breast carcinogenesis. Hence, and although the available data are controversial, we consider not only updated information on the epidemiology of vitamin D in breast cancer and its potential value as a therapeutic agent or prophylactic (with an emphasis on molecular mechanisms and effectors of vitamin D action), but include data on its role in other stages of breast cancer progression as well. Accordingly, we review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D-related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ.

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Nonnuclear Effects of the Steroid Hormone 1α,25(OH)2-Vitamin D3: Analogs Are Able to Functionally Differentiate Between Nuclear and Membrane Receptors

Cited by 61 publications

References 0 publications

Identification of a Membrane Receptor for 1,25-Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C

Identification of a Membrane Receptor for 1,25-Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

Vitamin D and the mammary gland: a review on its role in normal development and breast cancer

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