Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia

Abstract

During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of 4 was determined by using the modified Mosher method. Nonocarboline B (2) displayed moderate antifungal activity against Mucor hiemalis, while nonocarboline D (4) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC50 value of 1.7 µM.

Photobacterium arenosum WH24, Isolated from the Gill of Pacific Oyster Crassostrea gigas from the North Sea of Germany: Co-cultivation and Prediction of Virulence

“…The Invisorb Spin Plant Mini Kit was used to extract genomic DNA following the instruction of the kit manufacturers (Stratec Molecular, Germany). PCR amplification of the 16S rRNA gene was performed according to Primahana et al [ 25 ] with the primer F27 (5′AGAGTTTGATCMTGGCTCAG3′) and 1492R (5′TACGGYTACCTTGTTACGACTT-3′) [ 26 ]. The 16S rRNA gene was sequenced employing an Applied Biosystems 3730XL automated sequencer (ABI).…”

Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an Amycolatopsis sp. 195334CR

“…Strain 195334CR was obtained from a soil sample collected from Cultural Park Bali, Indonesia, according to a previously described method [ 29 ].…”

Activated Porous Carbon Derived from Tea and Plane Tree Leaves Biomass for the Removal of Pharmaceutical Compounds from Wastewaters

“…), which is mainly generated from the nature of the selected carbonaceous precursor [ 24 ]. Activated carbons present good properties due to their relatively low-cost and availability, their promising textural features, and tuneable surface chemistry heterogeneity [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. However, a disadvantage exists and is linked with the raw precursor from which ACs are synthesized, coconut shell, coal, and wood being the predominant feedstocks [ 33 ].…”