Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF

Yu, Mira; Kim, Juil; Ahn, Jung Hoon; Moon, Yuseok

doi:10.1172/jci.insight.125166

Cited by 36 publications

(39 citation statements)

References 50 publications

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“…Interestingly, an alternative approach to locally deliver EGF and reduce its proteolytic digestion involved administering E. coli bacteria that had been genetically modified to produce human EGF. This was seen to be beneficial in reducing dextran sodium sulphate (DSS)-induced colitis in mice [ 102 ].…”

Section: Constituents Of Bcmentioning

confidence: 99%

Bovine Colostrum: Its Constituents and Uses

2021

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Colostrum is the milk produced during the first few days after birth and contains high levels of immunoglobulins, antimicrobial peptides, and growth factors. Colostrum is important for supporting the growth, development, and immunologic defence of neonates. Colostrum is naturally packaged in a combination that helps prevent its destruction and maintain bioactivity until it reaches more distal gut regions and enables synergistic responses between protective and reparative agents present within it. Bovine colostrum been used for hundreds of years as a traditional or complementary therapy for a wide variety of ailments and in veterinary practice. Partly due to concerns about the side effects of standard Western medicines, there is interest in the use of natural-based products of which colostrum is a prime example. Numerous preclinical and clinical studies have demonstrated therapeutic benefits of bovine colostrum for a wide range of indications, including maintenance of wellbeing, treatment of medical conditions and for animal husbandry. Articles within this Special Issue of Nutrients cover the effects and use bovine colostrum and in this introductory article, we describe the main constituents, quality control and an overview of the use of bovine colostrum in health and disease.

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Section: Constituents Of Bcmentioning

confidence: 99%

Bovine Colostrum: Its Constituents and Uses

2021

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“…Chronic inflammation has been found to play a key role in the progression of colon cancers. Numerous studies have shown that inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis (UC), are associated with the development and progression of CRC [ 4 , 5 , 6 ]. It has been reported that 25% of patients with IBD have colon cancer [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT

Kim

Park

2020

Cancers

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Recently, it has been reported that Fusobacterium nucleatum, a major pathogen involved in chronic periodontitis, may play an important role in colorectal cancer (CRC) progression. In addition, inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease represent major predisposing conditions for the development of CRC, and this subtype of cancer is called colitis-associated cancer (CAC). Although the importance of F. nucleatum in CRC has attracted attention, its exact role and related mechanism in CAC progression remain unclear. In this study, we investigated the effects of F. nucleatum in experimental colitis induced with dextran sodium sulfate (DSS), which is a well-known colitis-inducing chemical, on the aggressiveness of CAC and its related mechanism in both in vitro and in vivo models. F. nucleatum synergistically increased the aggressiveness and epithelial–mesenchymal transition (EMT) characteristics of CRC cells that were treated with DSS compared to those in non-treated CRC cells. The role of F. nucleatum in CAC progression was further confirmed in mouse models, as F. nucleatum was found to significantly increase the malignancy of azoxymethane (AOM)/DSS-induced colon cancer. This promoting effect of F. nucleatum was based on activation of the EGFR signaling pathways, including protein kinase B (AKT) and extracellular signal-regulated kinase (ERK), and epidermal growth factor receptor (EGFR) inhibition significantly reduced the F. nucleatum-induced EMT alteration. In conclusion, F. nucleatum accelerates the progression of CAC by promoting EMT through the EGFR signaling pathway.

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“…Several studies showed that selected strains of bacteria can positively influence the gut barrier [ 16 , 17 ]. Moreover, it is suggested that food components can strengthen the integrity of the gut barrier, mostly by affecting the gut microbiota and restoring the microbial homeostasis [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet—Results of a Randomized, Placebo-Controlled, Pilot Trial

2020

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Abnormalities in the intestinal barrier are a possible cause of celiac disease (CD) development. In animal studies, the positive effect of prebiotics on the improvement of gut barrier parameters has been observed, but the results of human studies to date remain inconsistent. Therefore, this study aimed to evaluate the effect of twelve-week supplementation of a gluten-free diet (GFD) with prebiotic oligofructose-enriched inulin (10 g per day) on the intestinal permeability in children with CD treated with a GFD. A pilot, randomized, placebo-controlled nutritional intervention was conducted in 34 children with CD, being on a strict GFD. Sugar absorption test (SAT) and the concentrations of intestinal permeability markers, such as zonulin, intestinal fatty acid-binding protein, claudin-3, calprotectin, and glucagon-like peptide-2, were measured. We found that the supplementation with prebiotic did not have a substantial effect on barrier integrity. Prebiotic intake increased excretion of mannitol, which may suggest an increase in the epithelial surface. Most children in our study seem to have normal values for intestinal permeability tests before the intervention. For individuals with elevated values, improvement in calprotectin and SAT was observed after the prebiotic intake. This preliminary study suggests that prebiotics may have an impact on the intestinal barrier, but it requires confirmation in studies with more subjects with ongoing leaky gut.

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Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF

Cited by 36 publications

References 50 publications

Bovine Colostrum: Its Constituents and Uses

Bovine Colostrum: Its Constituents and Uses

Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT

Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet—Results of a Randomized, Placebo-Controlled, Pilot Trial

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