Nonoperative Management of Squamous-Cell Carcinoma of the Rectum

Péron, Julien; Bylicki, Olivier; Laude, C.; Carrié, C.; Racadot, S.

doi:10.1097/dcr.0000000000000218

Cited by 37 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Surgical resection is a consideration , but increasing numbers of recent studies are also finding merit to treat with definitive CRT using the anal SCC paradigm . Along with the data herein, several series have shown high clinical response as well as clinical complete response rates from 63% to 100% along with 5‐year overall survival, disease‐free survival, and disease‐specific survival rates of 81%, 72%, and 88%, respectively .…”

Section: Discussionmentioning

confidence: 60%

Comparison of outcomes between rectal squamous cell carcinoma and adenocarcinoma

et al. 2016

View full text Add to dashboard Cite

Large, population‐based analyses of rectal squamous cell carcinoma (SCC) have not been previously conducted. We assessed patterns of care, prognostic factors, and outcomes of rectal SCC and adenocarcinoma (AC) in population‐based cohorts. Surveillance, Epidemiology, and End Results (SEER) registry searches were performed (1998–2011), producing 42,308 nonmetastatic rectal cancer patients (999 SCC and 41,309 AC). Patient, tumor, and treatment characteristics were compared. Based on risk factors, SCC/AC groups were subdivided into low‐, intermediate‐, and high‐risk groups. Overall survival (OS) was compared between histological and risk groups using Kaplan–Meier method and log‐rank test. Multivariate logistic regression models evaluated prognostic factors for 5‐year survival. Cox regression modeling was performed on propensity‐matched data. Rectal SCC, more common in females and associated with larger tumors of higher grade, was more often treated with radiotherapy (RT) than surgery. Surgery was associated with higher OS in AC but not SCC, and RT had proportionally greater benefits in SCC. These effects of RT and surgery were retained when stratified into risk groups (particularly high/intermediate‐risk). Favorable prognostic factors for survival included younger age, non‐black race, SCC histology, size ≤3.9 cm, localized stage, lower grade, surgery, and RT. For SCC, race, tumor grade, and surgery were not prognostic factors for survival. Cox regression modeling of propensity‐matched data showed that AC histology increased risk of death versus SCC. In the largest analysis of rectal SCC to date, and in the notable absence (and unlikelihood) of prospective data, nonsurgical and RT‐based treatment is recommended.

show abstract

Section: Discussionmentioning

confidence: 60%

Comparison of outcomes between rectal squamous cell carcinoma and adenocarcinoma

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Overall, rectal SCC has a worse prognosis than adenocarcinoma and features associated with poor prognosis are ulcerated or annular carcinomas, node-positivity, and advanced stages (8). While many consider surgical resection the gold standard, some believe that chemotherapy with or without radiation may be curative, and some believe in neoadjuvant chemoradiation prior to tumor resection (9)(10)(11)(12)(13). It is best to individualize treatment based on patient functional status, concurrent comorbidities, tumor staging and local invasion.…”

Section: Discussionmentioning

confidence: 99%

A rare case of primary rectal squamous cell carcinoma diagnosed by endoscopic ultrasound

Kiyani

Coyle

Bao

2017

J. Gastrointest. Oncol.

View full text Add to dashboard Cite

Primary squamous cell carcinoma (SCC) of the rectum is a very rare entity making up to 0.1-0.25/1,000 cases of all colorectal cancers. Here, we present the case of an otherwise healthy 63-yearold female who presented with progressive pelvic discomfort, new onset constipation and a complex mass in presacral region on imaging which was proved to be poorly differentiated SCC of the rectum. The correct diagnosis was achieved by fine needle aspiration (FNA) via endoscopic ultrasound (EUS-guided FNA) as initial conventional colonoscopy failed to establish the diagnosis. Patient completed neoadjuvant chemoradiation and her tumor was successfully resected. She is following up with oncology clinic for monitoring and further management.

show abstract

“…Each of these modalities has been tried individually and in conjunction with others in combination treatment with different temporal relationships [12]. Success has been documented with almost all possible combinations of above modalities [12][13][14][15][16][17]. Surgery was traditionally used in concordance with treating anal canal SCC.…”

Section: Discussionmentioning

confidence: 99%

“…There has also been similar shift in preference towards definitive chemo-radiation for Rectal SCC [15,16,18,19]. A systematic review comparing chemo-radiation with traditional surgical approach demonstrated an overall survival of 86% in the chemoradiation group vs. 48% in surgery group.…”

Section: Discussionmentioning

confidence: 99%

Rare Primary Sub-Mucosal Rectal Squamous Cell Carcinoma Diagnosed with Endoscopic Ultrasound: Case Report and Literature Review

Sethi¹,

Aloreidi²,

Elnair³

et al. 2017

J Gastrointest Dig Syst

View full text Add to dashboard Cite

Primary rectal Squamous Cell Carcinoma (SCC) is a distinct and extremely rare form of colorectal malignancy and submucosal rectal SCC is rarer. The etiology and pathogenesis of rectal SCC is poorly understood. Given the rare occurrence of this type of malignancy, there are a number of diagnostic and therapeutic dilemmas. We are reporting a case of a 56-year-old female, who presented with abdominal pain and found to have rectal mass which was subsequently biopsied under endoscopic ultrasound guidance. Histopathology showed primary submucosal squamous cell carcinoma. She was treated with radiotherapy and systemic chemotherapy. Now she is undergoing regular malignancy surveillance.

show abstract

Nonoperative Management of Squamous-Cell Carcinoma of the Rectum

Cited by 37 publications

References 22 publications

Comparison of outcomes between rectal squamous cell carcinoma and adenocarcinoma

Comparison of outcomes between rectal squamous cell carcinoma and adenocarcinoma

A rare case of primary rectal squamous cell carcinoma diagnosed by endoscopic ultrasound

Rare Primary Sub-Mucosal Rectal Squamous Cell Carcinoma Diagnosed with Endoscopic Ultrasound: Case Report and Literature Review

Contact Info

Product

Resources

About