Nonpalpable breast tumors: diagnosis with contrast-enhanced subtraction dynamic MR imaging.

Gilles, R.; Guinebretière, Jean Marc; Lucidarme, Olivier; Cluzel, Philippe; Janaud, Gilbert; Finet, Jean François; Tardivon, A.; Masselot, J; Vanel, D.

doi:10.1148/radiology.191.3.8184038

Cited by 303 publications

(175 citation statements)

References 0 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…Although this technique is closely related to the vascularity of the lesions, there is no direct connection between the pattern of contrast enhancement and the amount of tumor cellularity (28). In the literature, some malignant lesions, including papillary, medullary, and some intraductal carcinomas, metastatic lesions, and lymphoma, have been reported to enhance more slowly and to a lesser degree than other malignant breast tumors (29,32). Besides, some benign breast lesions may imitate malignant lesions in terms of contrast uptake pattern due to proliferative activities of hyperplastic parenchymal cells (28).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, some benign breast lesions may imitate malignant lesions in terms of contrast uptake pattern due to proliferative activities of hyperplastic parenchymal cells (28). Particularly in the acute period of fat necrosis, proliferative dysplasia, and myxoid fibroadenoma, scar tissue formed very fast following surgical procedures (within first 6 months) and radiotherapy (within first 18 months) and vivid contrast uptake in the early period may be observed (32,33). In concordance with the literature, 5 malignant lesions of 35, including 2 of the medullary carcinoma, invasive mixed carcinoma, metaplastic carcinoma, and invasive lobular carcinoma revealed type 1 time signal intensity curve, as well as 5 of the fibroadenomas and one lesion of fat necrosis, were found to have type 3 curves (Figure 2, 3).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

T¹,

G²,

Sezgin³

et al. 2016

Balkan Med J

View full text Add to dashboard Cite

Background: Magnetic resonance imaging (MRI) has become a diagnostic and problem solving method for the breast examinations in addition to conventional breast examination methods. Diffusion-weighted imaging (DWI) adds valuable information to conventional MRI. Aims: Our aim was to show the impact of apparent diffusion coefficient (ADC) values acquired with DWI to differentiate benign and malignant breast lesions. Study Design: Diagnostic accuracy study. Methods: Forty-six women with 58 breast masses (35 malignant, 23 benign) were examined on a 1.5 T clinical MRI scanner. The morphologic characteristics of the lesions on conventional MRI sequences and contrast uptake pattern were assessed. ADC values of both lesions and normal breast parenchyma were measured. The ADC values obtained were statistically compared with the histopathologic results using Paired Samples t-Test. Results: Multiple lesions were detected in 12 (26%) of the patients, while only one lesion was detected in 34 (74%). Overall, 35 lesions out of 58 were histopathologically proven to be malignant. In the dynamic contrast-enhanced series, 5 of the malignant lesions were type 1, while 8 benign lesions revealed either type 2 or 3 time signal intensity curves (85% sensitivity, 56% spesifity Breast cancer is the most common cancer in females worldwide and the second main cause of cancer death following lung cancer. Approximately 12% of women will experience breast cancer during their lifetime (1). Therefore, breast cancer maintains its importance as a serious public health issue. The major risk factors comprise family history, genetic predisposition caused by the presence of a BRCA1 or BRCA2 gene mutation, and previously acquired breast lesions including fibrovascular papilloma, atypical ductal and lobular hyperplasia, and ductal and lobular carcinoma in situ (2,3).Imaging is crucial to diagnose and evaluate the stage and extent of breast cancer. Therefore, three types of radiologic techniques, including mammography, ultrasonography (US) and breast magnetic resonance imaging (MRI), are implemented. As a basic breast cancer scanning method, mammography is highly available, with a short scanning time.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

T¹,

G²,

Sezgin³

et al. 2016

Balkan Med J

View full text Add to dashboard Cite

show abstract

“…Some investigators who have concentrated on T1-weighted, time-signal intensity characteristics of gadolinium enhancement report very high specificities (83%-97%) (6,7,(17)(18)(19), but others have seen no significant difference between benign and malignant abnormalities (2,5,20). Investigators who have tried to directly compare the use of contrast enhancement kinetics to the use of architectural features have found architectural features to be superior to quantitative kinetic indices alone (13,14).…”

Section: Discussionmentioning

confidence: 99%

Optimal post‐contrast timing of breast MR image acquisition for architectural feature analysis

Nunes

Englander

Charafeddine

et al. 2002

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To define a post-contrast imaging time span during which diagnostic accuracy of breast magnetic resonance (MR) architectural feature analysis is maintained. Materials and Methods:Seventy-five patients with mammographically-visible or palpable findings underwent MR examination. Three sequential post-contrast, fat-saturated, three-dimensional gradient-echo imaging runs were acquired spanning 0 -90, 90 -180, and 180 -270 seconds after contrast injection. Five readers independently predicted the malignant potential of the MR abnormalities.Results: Receiver-operator characteristics (ROC) curves were our primary measure of diagnostic accuracy. The accuracy of four readers was unchanged over the three postcontrast runs. One reader was slightly more accurate using the second and third runs than using the first. Conclusion:For most readers, a single post-contrast run performed at any point during the first four minutes and 30 seconds following injection should yield an equivalent diagnostic accuracy. If any time period is less optimal, it is that of our first run, performed between 0 -90 seconds after contrast injection.

show abstract

“…Additionally, MRI has also proven to be useful in the assessment of the tumour response to chemotherapy (Thibault et al, 2004;Warren et al, 2004;Partridge et al, 2005;Segara et al, 2007). This good value of MRI in the evaluation of tumour response should also apply to ILC as, even though ILC is still a challenge for MRI (Kinkel and Hylton, 2001), the addition of MRI to mammography still increases the sensitivity in the detection of ILC (Gilles et al, 1994;Sittek et al, 1998) and, most importantly in the case of the response evaluation, the volumetric assessment is improved (Boetes et al, 2004;Fabre Demard et al, 2005;Caramella et al, 2007;Mann et al, 2008). This raises the question of whether patients who achieve complete clinical and imaging response could in some cases entirely avoid surgery.…”

Section: Discussionmentioning

confidence: 99%

High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies

et al. 2008

View full text Add to dashboard Cite

The literature reports low rates of breast conservation after neoadjuvant chemotherapy for operable breast cancers not amenable to initial breast-conserving surgery. This study aims to compare the outcome of lobular vs ductal carcinomas after neoadjuvant chemotherapy. Between 1989 and 1999, 750 patients with clinical stage II/IIIA ductal (672) or lobular (78) invasive breast carcinomas were treated at the Institut Curie with primary anthracycline-based polychemotherapy followed by either breast conservation (surgery and/or radiotherapy) or mastectomy. Median follow-up was 10 years. Clinical response to primary chemotherapy was significantly worse for lobular than for ductal carcinomas (47 vs 60%; P ¼ 0.04), but only histological grade remained predictive in multivariate analysis. Breast conservation was high for both ductal and lobular carcinomas (65 and 54%; P ¼ 0.07), due, in part, to the use of radiotherapy, either exclusive or preoperative, for respectively 26 and 40% of patients. The lobular type had no adverse effect, neither on locoregional control nor on overall survival, even in the group of patients treated with breast conservation.

show abstract

Nonpalpable breast tumors: diagnosis with contrast-enhanced subtraction dynamic MR imaging.

Abstract: Subtraction dynamic MR imaging may be helpful to rule out malignancy in nonpalpable breast tumors.

Cited by 303 publications

References 0 publications

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

Optimal post‐contrast timing of breast MR image acquisition for architectural feature analysis

High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies

Contact Info

Product

Resources

About