Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review

Santos, Heitor O.; Cadegiani, Flavio; Forbes, Scott C.

doi:10.1016/j.clinthera.2022.06.006

Cited by 17 publications

(18 citation statements)

References 161 publications

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“…In male adolescents who did not seek therapy, FT and DHEA‐S lower the pain threshold for palpation pain in the TM region. It is only when sex hormones are severely reduced or absent that multiple biopsychosocial impairments become apparent, which must be alleviated by hormonal substitution 38 . The observations made in our investigation are not strong from a clinical risk perspective.…”

Section: Discussioncontrasting

confidence: 57%

“…It is only when sex hormones are severely reduced or absent that multiple biopsychosocial impairments become apparent, which must be alleviated by hormonal substitution. 38 The observations made in our investigation are not strong from a clinical risk perspective. Nonetheless, they are significant they may explain why patients with musculoskeletal facial pain often do not have a pathophysiological macroanatomical correlate to the magnitude of the reported complaints, which is also the case with other types of pain.…”

Section: F I G U R Econtrasting

confidence: 56%

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Sex hormones associated with temporomandibular pain on palpation in male adolescents—Results of the epidemiologic LIFE child study

Hirsch¹,

Schierz

Körner³

et al. 2023

J of Oral Rehabilitation

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ObjectiveThis study aimed to investigate whether the sex steroid precursor hormone dehydroepiandrosterone sulphate (DHEA‐S), sex hormone‐binding globulin (SHBG) and testosterone (TT) are associated with temporomandibular (TM) pain on palpation in male adolescents.MethodsOut of the LIFE Child study dataset containing 1022 children and adolescents aged 10–18 years (496 males, 48.5%), we used a subsample of 273 male adolescents (mean age: 13.8 ± 2.3 years) in advanced pubertal development (PD) to analyse the association between hormones and TM pain. The Tanner scale was applied to describe the stage of PD. Pain on palpation of the temporalis and masseter muscles and the TM joints (palpation pain) was assessed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Serum levels of sex hormones (DHEA‐S, SHBG and TT) were determined using standardised laboratory analyses. Free TT was estimated from the ratio between TT and SHBG (free androgen index[FAI]). We calculated the risk of perceived positive palpation pain for male participants as a function of hormone levels (DHEA‐S, FAI) taking into account age and body mass index (BMI).ResultsAmong more developed (Tanner stage 4–5) male adolescents, 22.7% (n = 62) reported palpation pain in the TM region. In these participants, FAI levels were approximately half that of individuals without such pain (p < .01). DHEA‐S levels were about 30% lower in the pain group (p < .01). In multivariable regression analyses, the odds ratio (OR) for pain on palpation decreased to 0.75 (95% confidence interval [CI]: 0.57–0.98) per 10 units of FAI level compared to those without pain, after controlling for the effects of age and adjusted BMI. We observed the same effect for this subgroup per unit of DHEA‐S serum level (OR = 0.71; 95% CI: 0.53–0.94).ConclusionAt subclinical lower levels of serum free TT and DHEA‐S, male adolescents are more likely to report pain on standardised palpation of the masticatory muscles and/or TM joints. This finding supports the hypothesis that sex hormones may influence pain reporting.

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Section: Discussioncontrasting

confidence: 57%

Section: F I G U R Econtrasting

confidence: 56%

Sex hormones associated with temporomandibular pain on palpation in male adolescents—Results of the epidemiologic LIFE child study

Hirsch¹,

Schierz

Körner³

et al. 2023

J of Oral Rehabilitation

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“…Based on the results of 35 studies, it was determined that such plants as Apium graveolens, Cinnamomum camphora, Cornus mas, Satureja khuzestanica, Withania somnifera, Fumaria parviflora, Zingiber officinale, Cinnamomum zeylanicum and Phoenix dactylifera had a positive effect on reproduction, and demonstrated antioxidant effects and a low frequency of side effects (Boroujeni et al 2022). Many nutraceuticals can stimulate steroidogenesis in men, according to Santos et al (2022). However, only a small number of these products (zinc, vitamin D (in the case of hypovitaminosis D), L-arginine, Mucuna pruriens, and Withania somnifera) demonstrate promising results based on the results of high-quality randomized controlled trials (Santos et al 2022).…”

Section: Resultsmentioning

confidence: 99%

“…Many nutraceuticals can stimulate steroidogenesis in men, according to Santos et al (2022). However, only a small number of these products (zinc, vitamin D (in the case of hypovitaminosis D), L-arginine, Mucuna pruriens, and Withania somnifera) demonstrate promising results based on the results of high-quality randomized controlled trials (Santos et al 2022). These same natural substances, along with Tribulus terrestris and ω-3 polyunsaturated fatty acids, can somewhat improve the parameters of the ejaculate in infertile men, with the exception of L-arginine (Santos et al 2022).…”

Section: Resultsmentioning

confidence: 99%

“…However, only a small number of these products (zinc, vitamin D (in the case of hypovitaminosis D), L-arginine, Mucuna pruriens, and Withania somnifera) demonstrate promising results based on the results of high-quality randomized controlled trials (Santos et al 2022). These same natural substances, along with Tribulus terrestris and ω-3 polyunsaturated fatty acids, can somewhat improve the parameters of the ejaculate in infertile men, with the exception of L-arginine (Santos et al 2022). Ahmadian et al (2022) performed a systematic review in order to assess the most recent scientific data on herbal substances used for the treatment of idiopathic male infertility (Ahmadian et al 2022).…”

Section: Resultsmentioning

confidence: 99%

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Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Bratchikov,

Tyuzikov,

Grekov

2023

RRP

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Introduction: Male infertility is an topical medical and social problem of modern reproductive medicine. Its pharmacotherapy is often empirical in nature, and the most popular method remains the use of various herbal substances (phytotherapy), the effectiveness of which remains still understudied in the framework of evidence-based medicine. Materials and Methods: The results of research, thematic, systematic and Cochrane reviews and meta-analyses were searched in Medline/PubMed medical databases over the past 5 years using the search queries "plants male infertility", "plants sperm", "phytotherapy male infertility", "phytomedicinal therapeutics male infertility", "systematic review", "meta-analysis", and "review". Results: The vast majority of herbal substances offered for the treatment of male infertility demonstrate insufficient or contradictory evidence base for their clinical effectiveness, although some of them can be very useful pharmacotherapeutic options in the combined therapy of male infertility. Conclusion: Not all plant substances with a "reproductive effect" positioned in them actually have proven reproductive effects in studies in humans, therefore, the choice of phytotherapeutic agents in the treatment of idiopathic male infertility should be currently approached extremely carefully, especially in cases when we choose phytotherapy as an option for empirical monotherapy of male reproductive disorders.

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Correlation of heavy metals’ exposure with the prevalence of coronary heart disease among US adults: findings of the US NHANES from 2003 to 2018

Zhang

Zhao

et al. 2023

Environ Geochem Health

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Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review

Cited by 17 publications

References 161 publications

Sex hormones associated with temporomandibular pain on palpation in male adolescents—Results of the epidemiologic LIFE child study

Sex hormones associated with temporomandibular pain on palpation in male adolescents—Results of the epidemiologic LIFE child study

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Correlation of heavy metals’ exposure with the prevalence of coronary heart disease among US adults: findings of the US NHANES from 2003 to 2018

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