Nonpigmenting Fixed Drug Eruption due to Pseudoephedrine

Fixed drug eruption (FDE): changing scenario of incriminating drugs

“…Recently, NFDE has also been recorded, in which the lesions heal completely without any trace of pigmentation on the skin 24–30 . Recurrence at the previously affected site confirms the diagnosis in these instances 24,26–29,48–50 . FDE may be asymptomatic or may be accompanied by burning or stinging/pruritus, or prominent local or systemic manifestations 5,6,21,22 .…”

“…The authors named it nonpigmenting fixed drug eruption (NFDE). This entity has been recognized and reported with different drugs 25–30 …”

“…[71][72][73][74][75][76][77] There are reports of localized bullous pemphigoid resembling bullous FDE, 212 or FDE masquerading as herpes (simplex) labialis 213 or discoid lupus erythematosus. 214 Similarly, NFDE, where a tendency to resolve completely after the attack is apparent, [26][27][28][29][30][48][49][50] must be considered in the differential diagnosis.…”

Phenylephrine induced fixed drug eruption: a rare case of cross sensitivity

“…14 The literature contains many reports of contact dermatitis to phenylephrine and FDEs due to pseudoephedrine. 15,16 One report of fixed drug eruption due to phenylepherine is also documented. 17 One report of cross sensitivity between phenylepherine and ethylepherine is also reported.…”

Acute generalized exanthematous pustulosis associated with pseudoephedrine

“…Adverse reactions to sympathomimetic drugs are rare despite extensive use. Nonpigmented fixed exanthema, 3,4 and generalized scarlatiniform 5 or eczematous eruptions 6 have been reported.…”