Nonsebaceous lymphadenoma of salivary glands: proposed development from intraparotid lymph nodes and risk of misdiagnosis

Weiler, Christoph; Agaimy, Abbas; Zengel, Pamela; Zenk, Johannes; Kirchner, Thomas; Ihrler, Stephan

doi:10.1007/s00428-012-1225-z

Cited by 27 publications

(28 citation statements)

References 20 publications

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“…In the present study, this type of tumor was observed to be well circumscribed and exhibited typically benign behaviors, with the majority of the cases affecting adults aged >30 years (80%). Of the 10 cases, approximately one-third exhibited sebaceous differentiation to an extent, which was the opposite to the findings of a previous study (3). The underlying specific reasons for this phenomenon are not yet clear.…”

Section: Discussioncontrasting

confidence: 91%

“…A strong argument for this hypothesis are that studies have identified an unequivocal hilus structure with embryonic parenchymal inclusions, in conjunction with frequent secondary follicles and lymph vessels within the marginal sinus structures (2,3,7,10). However, this theory is in conflict with the majority of studies, which instead regard the lymphoid component as reactive tumor-associated lymphoid tissue (6,8,11–13).…”

Section: Discussionmentioning

confidence: 99%

“…Since the first report in 1960 by McGavran et al (1), to the best of our knowledge, <110 cases of the salivary gland have been reported in the English language literature. However, this may be due to diagnostic difficulty as this type of tumor partially resembles numerous other types of salivary gland neoplasm, including cystadenoma, Warthin’s tumor and pleomorphic adenoma; even mucoepidermoid carcinoma or metastatic adenocarcinoma may enter into the differential diagnosis (1–3). The present study reports a large series of cases of lymphadenoma of the salivary gland in the Chinese population, with a complete analysis of the clinical and pathological data to enable the discussion of the features of the clinical diagnosis and histogenesis in these cases.…”

Section: Introductionmentioning

confidence: 99%

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Lymphadenoma of the salivary gland: Report of 10 cases

Liu

Zhang

et al. 2014

Oncology Letters

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Lymphadenoma of the salivary gland is rare, and the typical characteristics of lymphadenoma remain poorly understood. The aim of this study was to analyze the experience of a single institution in the clinical diagnosis, treatment and prognosis of this type of tumor of the salivary gland. All cases of lymphadenoma diagnosed at the institution between 1996 and 2012 were analyzed. The clinical information (including age, gender and tumor location, process of tumor development, imaging data, surgical treatment and follow-up information) and pathological features were evaluated. All tumors occurred in the parotid glands; three cases were sebaceous lymphadenoma (two male and one female) and seven were non-sebaceous lymphadenoma (three male and four female). The average ages of the patients were 68.3 and 42.4 years for the sebaceous and non-sebaceous groups, respectively. The majority of cases (90%) were diagnosed as pleomorphic adenoma or adenolymphoma prior to surgery, but were confirmed as lymphadenoma by pathological analysis following surgery. During the follow-up period, which ranged between 3 and 36 months with a mean of 30 months, no recurrence of the lesion was identified and the quality of life was good for each patient. In conclusion, the diagnosis of salivary gland lymphadenoma should be based on the clinical and, in particular, the pathological manifestations of the disease. Immunohistochemistry is considered as a practical and helpful adjuvant method of the diagnosis for this type of tumor. Complete surgical resection is the first choice of treatment. Further exploration of the histological origin of lymphadenoma of the salivary gland is necessary due to the insufficient number of reported cases.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lymphadenoma of the salivary gland: Report of 10 cases

Liu

Zhang

et al. 2014

Oncology Letters

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“…In the 2005 World Health Organization Classification of Tumors, NSL is classified as a subtype of lymphadenoma, together with sebaceous lymphadenoma . Since 1991, to the best of our knowledge, only 37 cases of NSL have been reported in the literature, and none of the reported tumors showed the differentiation to serous acinic cell lineage. Here, we present for the first time a case of NSL of the parotid gland with serous acinic cell differentiation.…”

mentioning

confidence: 99%

Non‐sebaceous lymphadenoma of the salivary gland with serous acinic cell differentiation, a first case report in the literature

Ishii

Kawano

Tanaka

et al. 2013

Pathology International

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We report an atypical case of non-sebaceous lymphadenoma (NSL) of the parotid gland showing serous acinic cell differentiation. NSL is a rare benign salivary gland tumor with intermingled lymphoid and epithelial tissues without sebaceous differentiation. Since the first description of a case designated by Auclair et al. as 'non-sebaceous lymphadenoma' in 1991, to our best knowledge, only 37 cases have been reported, and no differentiation of tumor cells into serous acinic cell lineage has been described so far. In this paper, we present a case of NSL with serous acinic cell differentiation. The patient was a 78-year-old female with the complaint of a painless mass in the left parotid gland. The surgically resected tumor was encapsulated and measured 13 × 9 × 9 mm. Histologically, the tumor had the features of NSL, and an unusual finding of this case was the presence of epithelial cells with serous acinic cell differentiation. Dense cytoplasm packed with basophilic granules in those cells was positive in periodic acid Schiff reaction after diastase digestion (D-PAS), which was compatible with the feature of serous acinic cell differentiation. Possible differentiation of the epithelial component into serous acinic cell in this rare entity is warranted to avoid confusion in the diagnosis.

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“…Some may have argued that lymphadenoma may represent an adenoma arising from heterotopic salivary tissue in an intra-or periparotid lymph nodes. Hilus structure with salivary inclusions or D2-40 (podoplanin)-positive marginal sinus was identifi ed in four and nine of their nine cases, respectively [ 168 ]. On the other hand, others have not demonstrated recognisable lymph node structures with sinuses, and furthermore, the lymphoid component is by many considered to represent tumour-associated lymphoid proliferation [ 7 , 41 ].…”

Section: Lymphadenomamentioning

confidence: 99%