Nonselectivity of the chloride ion-selective electrode used in the Hitachi 705.

Mercuracarborand “Anti-Crown Ether”-Based Chloride-Sensitive Liquid/Polymeric Membrane Electrodes

“…For example, anion exchangers have been explored as the electroactive species for the development of chloride-sensitive liquid/polymeric membrane electrodes. − However, these anion-exchanger-based chloride sensors lack selectivity over more lipophilic anions, and the sensors respond significantly to more lipophilic anions according to the well-known Hofmeister series (i.e., the response pattern is based on the lipophilicity of the anions). Indeed, chloride determination in physiological fluids (e.g., serum and plasma) using anion-exchanger-based membrane electrodes gave misleading results with high positive errors due to insufficient selectivity over the more lipophilic anions 2,7-9 and some of the hydrophilic anions. , …”