In this study, adaptive prescribed finite-time stabilisation of uncertain single-input and single-output non-linear systems is considered in the presence of unknown states, unknown parameters, external load disturbance, and non-symmetric input saturation. A prescribed finite time disturbance observer is designed to approximate the unmeasured external disturbance. Also, a non-singular prescribed finite time terminal sliding mode control is proposed for the closed-loop control of the system with the non-symmetric input saturation. Extended Kalman filter algorithm is employed for the real-time estimations of the states and unknown parameters of the system. Moreover, a particle swarm optimisation algorithm is used to obtain the design parameters of the proposed disturbance observer and controller. To show the performance of designed control scheme, the proposed approach is employed to guarantee prescribed finite time stabilisation of non-linear vibration of a non-local strain gradient nanobeam. The Galerkin projection method is used to reduce the non-dimensional form of the governing non-linear partial differential equation of Euler-Bernoulli nanobeam to the ordinary differential equation. Finally, numerical simulations are performed to illustrate the effectiveness and performance of the developed adaptive control scheme for the vibration control of nanobeam in comparison with the conventional sliding mode control.