Nonspecific immunoprevention of L1210 leukemia by cord factor (6-6? dimycolate of trehalose) administered in a metabolizable oil

Lamensans, A; Chedid, L; Drapier, Jean‐Claude; Petit, Jean‐François; Lederer, E.

doi:10.1007/bf00200097

Cited by 28 publications

(14 citation statements)

References 19 publications

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“…It is well documented that when injected in suspen sion in paraffin oil or in an oil in water emulsion, Cord factor stimulates resistance to infections in duced by various bacteria [Parantet al, 1977] or para sites and may control the development of tumors, lntraperitoneal injection of TDM in Bayol F, or in an emulsion of saline and peanut oil protects mice against LI2I0 leukemia cells [ Leclerc et al, 1976], TDM and its synthetic C76 analogue, injected intralesionally into a methylcholanthrene-induced fibrosar coma, cause up to 100% regression of the established tumor, if incorporated in an emulsion of 9% paraffin oil in saline. Most of the cured mice were resistant to growth of tumor cells in a challenge inoculum [ Yarkoni et al, 1978], The growth of an ascitic rat hepatoma is suppressed by i.p.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of in vitro and in vivo Antitumor Activity by Cord Factor (6-6′-Dimycolate of Trehalose) Administered Suspended in Saline

Orbach-Arbouys

Tenu

Petit

1983

Int Arch Allergy Immunol

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The antitumor activity of trehalose-6,6′-dimycolate (TDM) dispersed in saline was studied in vitro and in vivo. In vitro, macrophages from TDM-treated mice entirely abolish, even at a 1.25:1 effector/target cell ratio, the (³H)TdR incorporation of P815 mastocytoma cells to the culture in which they were added. In vivo, the number of P815 cells harvested 10 days after their injection into TDM-treated mice was reduced by a factor higher than 50. The slopes of the radiolabel elimination of TDM-treated mice injected with 10⁷¹²⁵I-UdR-labelled L1210 leukemic cells were greater than those of untreated controls. The interest of such a compound which seems to be one of the active structures responsible for the antitumor activity of BCG is its efficiency when administered dispersed in saline.

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Section: Discussionmentioning

confidence: 99%

Enhancement of in vitro and in vivo Antitumor Activity by Cord Factor (6-6′-Dimycolate of Trehalose) Administered Suspended in Saline

Orbach-Arbouys

Tenu

Petit

1983

Int Arch Allergy Immunol

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“…The vehicle chosen for these agents was initially a relatively low concentration of metabolizable vegetable oil held in emulsion in Triton WR1339 solution, based on the observations of Leclerc et al (1976) on the cord factor treatment of the ascitic L1210 mouse leukaemia. By means of this vehicle, the relative anti-tumour properties of five trehalose diesters have been assessed.…”

mentioning

confidence: 99%

Immunotherapy of an ascitic rat hepatoma with cord factor (trehalose‐6, 6′‐dimycolate) and synthetic analogues

Pimm

Baldwin

Polonsky

et al. 1979

Intl Journal of Cancer

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The ability of cord factor (trehalose-6, 6'-dimycolate) and a range of shorter carbon chain fatty acid trehalose diesters to suppress growth of an ascitic rat hepatoma has been examined and compared with that of whole, living BCG organisms. Aqueous suspensions of BCG, and cord factor in 0.4% arachis oil:Triton emulsion, injected intraperitoneally, retarded growth of up to 10(5) ascites tumour cells. Trehalose-6, 6'-dibehenate was also tumour-suppressive, but only against lower challenge inocula (10(4) cells). Trehalose-6, 6'-dipalmitate and 6,6'-di-0-2-tetradecyl -3-hydroxyoctadecanoyl alpha, alpha trehalose (designated C76) were virtually ineffective and 6,6' -di-0-2-eicosyl-3-hydroxy-tetracosanoyl alpha, alpha trehalose (designated C100) gave small and variable effects only against low challenge inocula. However, improved responses were seen with light mineral oil in place of arachis oil in the emulsions.

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“…In addition, ADCMC is known to be enhanced by an immunoadjuvant such as FCA (Allison, 1973). In previous studies IPM has been shown to enhance immunity against experimental murine tumors (Lamensans et al, 1975;Leclerc et al, 1976) and to activate macrophages in vivo and in vitro, enabling them to inhibit the growth of neoplastic target cells (Juy and Chedid, 1975). These D. Juy and C. Leclerc: Enhancement of ADCMC by Immunoadjuvant observations prompted us to investigate the effect of IPM on ADCMC.…”

Section: Discussionmentioning

confidence: 94%

“…IPM is a potent antitumoral agent in mice (Lamensans et al, 1975;Leclerc et al, 1976). It also stimulates blast transformation of lymphocytes and nonspecifically activates macrophages (Juy and Chedid, 1975).…”

Section: Reprint Requests Shoum Be Addressed To: Dominique Juymentioning

confidence: 99%

Enhancement of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCMC) by an Interphase Material (IPM) extracted from a non-pathogenic strain of mycobacteria

Juy

1977

Cancer Immunol Immunother

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Nonspecific immunoprevention of L1210 leukemia by cord factor (6-6? dimycolate of trehalose) administered in a metabolizable oil

Cited by 28 publications

References 19 publications

Enhancement of in vitro and in vivo Antitumor Activity by Cord Factor (6-6′-Dimycolate of Trehalose) Administered Suspended in Saline

Enhancement of in vitro and in vivo Antitumor Activity by Cord Factor (6-6′-Dimycolate of Trehalose) Administered Suspended in Saline

Immunotherapy of an ascitic rat hepatoma with cord factor (trehalose‐6, 6′‐dimycolate) and synthetic analogues

Enhancement of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCMC) by an Interphase Material (IPM) extracted from a non-pathogenic strain of mycobacteria

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