Nonspecific interstitial pneumonia with fibrosis: serial high-resolution CT findings with functional correlation.

Kim, E Y; Lee, K S; Chung, Man Pyo; Kwon, Oh‐Jung; Kim, T S; Hwang, Jung Hye

doi:10.2214/ajr.173.4.10511155

Cited by 71 publications

(38 citation statements)

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“…a combination of reticular opacities, traction bronchiectasis and honeycomb cysts, in the absence of prominent ground glass attenuation or consolidation) was not found in any case, although this diagnosis was eventually considered the most likely in the two cases pathologically diagnosed with UIP. None of the cases with a pathological diagnosis of NSIP had CT findings suggestive of UIP; in 10 of 11 cases, CT findings included a combination of ground glass opacities, intralobular reticular opacities, irregular linear opacities, and traction bronchiectasis, compatible with published descriptions of NSIP [8,[15][16][17][18]. CT findings were considered more suggestive of organising pneumonia in the remaining case of NSIP.…”

Section: Computed Tomography Of the Chestsupporting

confidence: 65%

Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

et al. 2003

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This study investigated interstitial pneumonia associated with amyopathic dermatomyositis, dermatomyositis and polymyositis, paying particular attention to muscular and/or cutaneous manifestations and their chronology relative to lung involvement. Patients included four males and 13 females, aged 51.7±10.8 yrs, who had surgical lung biopsy.Diagnoses included dermatomyositis (10 patients), polymyositis (four patients) and amyopathic dermatomyositis (three patients). Solitary respiratory manifestations preceded the onset of any skin or muscle disease in four cases (24%). Reticular and ground glass opacities were the most frequent computed tomography (CT) findings. Pathological review showed nonspecific interstitial pneumonia (eleven, 65%; cellular, two; cellular and fibrotic, five; fibrotic, four), usual interstitial pneumonia (two), organising pneumonia (two), lymphocytic interstitial pneumonia (one), and unclassifiable interstitial pneumonia (one). Nonspecific interstitial pneumonia was the most common histological pattern of interstitial pneumonia in patients with amyopathic dermatomyositis (three of three) and in patients with respiratory symptoms as the initial clinical manifestation of the connective tissue disease (three of four). Survival at 5 yrs was 50%.This study shows the clinician should remain alert to potential muscular or cutaneous manifestations whenever a pathological diagnosis of nonspecific interstitial pneumonia is made.

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Section: Computed Tomography Of the Chestsupporting

confidence: 65%

Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

et al. 2003

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“…Response to treatment and overall prognosis are distinct, however, with progressive deterioration of lung function and early death the norm in UIP, whereas stabilization or improvement is more typical of NSIP. [1][2][3][4] The 5-year survival rate in NSIP is 70% to 100%. 5 In contrast, UIP is nearly uniformly fatal, with a median survival of approximately 3 years.…”

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confidence: 99%

High-Resolution Computed Tomography Features of Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia

Elliot¹,

Lynch²,

Newell³

et al. 2005

Journal of Computer Assisted Tomography

134

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In contrast to previous reports, NSIP can be separated from UIP in most cases. The presence of honeycombing as a predominant imaging finding is highly specific for UIP and can be used to differentiate it from NSIP, particularly when the distribution is patchy and subpleural predominant. The presence of predominant ground-glass and reticular opacity is highly characteristic of NSIP, but there is a subset of patients with UIP who have this pattern and may require biopsy for differentiation from NSIP.

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“…As with other patterns of injury, it would be reasonable to surmise that GGO and consolidation represent findings with a significant reversible component, and several papers have demonstrated that these findings decrease in extent after treatment [28][29][30]. Additionally, at least one study has shown improvements in FVC and diffusing capacity of the lungs for carbon monoxide (DLCO) associated with the decrease in GGO [31]. On the other hand, SUMIKAWA et al [27] showed significant discordance between imaging and pathological findings with respect to the presence of inflammation or fibrosis.…”

Section: Nonspecific Interstitial Pneumoniamentioning

confidence: 99%

The role of high-resolution computed tomography in the follow-up of diffuse lung disease

2017

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High-resolution computed tomography (HRCT) of the lung is a key component of the multidisciplinary approach to diagnosis in diffuse lung disease (DLD). HRCT also plays an important role in the follow-up of patients with established DLD. In this respect, serial HRCT examinations may provide valuable information that cannot be determined from clinical history and other diagnostic tests, such as pulmonary function tests. Important roles of HRCT in this context include assisting in determining prognosis, monitoring for the efficacy of treatment, detecting progression of disease or complications, and evaluating patients with worsening or acute symptoms. Both clinicians and radiologists should be aware of the expected evolution of HRCT changes in a variety of DLDs. The goals of this paper are to discuss: 1) the expected evolution of HRCT findings over time in common DLDs; 2) the role of serial HRCT examinations in formulating an initial diagnosis; and 3) the role of HRCT in the follow-up of patients with known DLD.

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Nonspecific interstitial pneumonia with fibrosis: serial high-resolution CT findings with functional correlation.

Cited by 71 publications

References 0 publications

Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

High-Resolution Computed Tomography Features of Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia

The role of high-resolution computed tomography in the follow-up of diffuse lung disease

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