Nonspecific Lymphocytic Myocarditis in Baboons Is Associated with Trypanosoma cruzi Infection

Andrade, Márcia Cristina Ribeiro; Dick, Edward J.; Guardado-Mendoza, Rodolfo; Hohmann, Michaelle L.; Mejido, Diana C.P.; VandeBerg, John L.; DiCarlo, Cheryl Dawn; Hubbard, Gene B.

doi:10.4269/ajtmh.2009.81.235

Cited by 17 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study from our institute reported an association between nonspecific lymphocytic myocarditis and T. cruzi serology positivity in baboons 29 ; our results further confirm that association and extend it to our cynomolgus monkey colony.…”

Section: Discussionsupporting

confidence: 91%

Correlation between Presence of Trypanosoma cruzi DNA in Heart Tissue of Baboons and Cynomolgus Monkeys, and Lymphocytic Myocarditis

Mubiru¹,

Yang²,

Dick³

et al. 2014

The American Society of Tropical Medicine and Hygiene

Self Cite

View full text Add to dashboard Cite

Abstract. Trypanosoma cruzi, the causative agent of Chagas' disease, preferentially infects cardiac and digestive tissues. Baboons living in Texas (Papio hamadryas) and cynomolgus monkeys (Macaca fascicularis) have been reported to be infected naturally with T. cruzi. In this study, we retrospectively reviewed cases of animals that were diagnosed with lymphocytic myocarditis and used a polymerase chain reaction (PCR)-based method (S36/S35 primer set) to amplify T. cruzi DNA from archived frozen and formalin-fixed paraffin-embedded (FFPE) cardiac tissues. We show that the PCR method is applicable in archived frozen and FFPE tissues and the sensitivity is in the femtogram range. A positive correlation between PCR positivity and lymphocytic myocarditis in both baboons and cynomolgus monkeys is shown. We also show epicarditis as a common finding in animals infected with T. cruzi.

show abstract

Section: Discussionsupporting

confidence: 91%

Correlation between Presence of Trypanosoma cruzi DNA in Heart Tissue of Baboons and Cynomolgus Monkeys, and Lymphocytic Myocarditis

Mubiru¹,

Yang²,

Dick³

et al. 2014

The American Society of Tropical Medicine and Hygiene

Self Cite

View full text Add to dashboard Cite

show abstract

“…cruzi infections have been reported in a number of New World species including marmoset, squirrel, spider, cebus, and woolly monkeys, and Old World species including baboons, macaques, and great apes (Williams et al, 2009;Andrade et al, 2009;Mubiru et al, 2014;Kunz et al, 2002). cruzi infections have been reported in a number of New World species including marmoset, squirrel, spider, cebus, and woolly monkeys, and Old World species including baboons, macaques, and great apes (Williams et al, 2009;Andrade et al, 2009;Mubiru et al, 2014;Kunz et al, 2002).…”

Section: A Pathogenesismentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

View full text Add to dashboard Cite

“…Animals with anomaly-related mortality were more likely to have died (9, 75.0%) than to have been euthanized. The most common anomalies encountered were aortic aneurism rupture (5), atrial septal defect (2), and patent foramen ovale (2). Other anomalies seen once each were cardiac dysplasia, pulmonary artery stenosis, persistent ductus arteriosus, and tetrology of Fallot.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Mortality in captive baboons (Papio spp.): a‐23‐year study

Dick

Owston

David

et al. 2014

J of Medical Primatology

Self Cite

View full text Add to dashboard Cite

Background We report the causes of mortality for 4,350 captive baboons that died or were euthanized due to natural causes during a 23 year period at the Southwest National Primate Research Center. Methods Necropsy records were retrieved and reviewed to determine a primary cause of death or indication for euthanasia. Data was evaluated for morphological diagnosis, organ system and etiology. Results The 20 most common morphologic diagnoses accounted for 76% of the cases, including: stillborn (10.8%); colitis (8.6%); hemorrhage (8.4%); ulcer (5.2%); seizures (4.7%); pneumonia (4.2%); inanition (4.1%); dermatitis (3.8%); spondylosis (3.3%); and amyloidosis (3.0%). The digestive system was most frequently involved (21.3%), followed by the urogenital (20.3%), cardiovascular (12.2%), and multisystem disease (10.3%). An etiology was not identified in approximately one third of cases. The most common etiologies were trauma (14.8%), degenerative (9.5%), viral (8.7%), and neoplastic/proliferative (7.0%). Conclusion This information should be useful for individuals working with baboons.

show abstract

Nonspecific Lymphocytic Myocarditis in Baboons Is Associated with Trypanosoma cruzi Infection

Cited by 17 publications

References 19 publications

Correlation between Presence of Trypanosoma cruzi DNA in Heart Tissue of Baboons and Cynomolgus Monkeys, and Lymphocytic Myocarditis

Correlation between Presence of Trypanosoma cruzi DNA in Heart Tissue of Baboons and Cynomolgus Monkeys, and Lymphocytic Myocarditis

Nonhuman Primates

Mortality in captive baboons (Papio spp.): a‐23‐year study

Contact Info

Product

Resources

About