2023
DOI: 10.1101/2023.10.23.563088
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Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

Richard T Eastman,
Radda Rusinova,
Karl F Herold
et al.

Abstract: Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the potential for ivermectin to be repurposed as an antiviral agent, we therefore undertook a series of preclinical studies. Consistent with early reports, ivermectin decreased SARS-CoV-2 viral burden in in vitro models at low micromolar concentrations, five- to ten… Show more

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