Nonspecific Proctocolitis in Northeastern Scotland: A Community Study

Sinclair, T. S.; Brunt, P. W.; Ashley, Neil; Mowat, G. N.

doi:10.1016/s0016-5085(83)80221-2

Cited by 183 publications

(41 citation statements)

References 33 publications

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“…Whereas we report incidence rates for ulcerative colitis that are comparable with some other northern populations (19,(21)(22)(23)(24)(25), we report the highest incidence of Crohn's disease to date (1,2). These observations would hold even if our incidence rates are overestimated by up to 20 percent due to case definition.…”

Section: Discussionsupporting

confidence: 72%

Epidemiology of Crohn's Disease and Ulcerative Colitis in a Central Canadian Province: A Population-based Study

Bernstein

Blanchard

Rawsthorne

et al. 1999

American Journal of Epidemiology

612

405

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The aim of this study was to assess the accuracy and utility of administrative health data in identifying persons with inflammatory bowel disease on a population basis and to determine the incidence and prevalence of this disease in the Canadian province of Manitoba. The data from Manitoba Health (the province's single insurer) were used to identify residents with physician and/or hospital contacts for Crohn's disease or ulcerative colitis based on International Classification of Diseases, Ninth Revision, Clinical Modification, codes between 1984 and 1995. Of 5,182 eligible individuals, 4,514 were mailed questionnaires and 2,725 responded. Cases were defined as individuals with five or more separate medical contacts with one of these diagnoses or three or more such contacts if they were resident for less than 2 years. The accuracy of the study case definitions was high when compared with either self-report or chart review. The 1989-1994 age- and sex-adjusted annual incidence was 14.6/100,000 for Crohn's disease and 14.3/100,000 for ulcerative colitis. The prevalence of Crohn's disease in 1994 was 198.5/100,000, and that of ulcerative colitis was 169.7/100,000. In conclusion, the authors have successfully established and validated a population-based database of inflammatory bowel disease based on administrative data. The high incidence rates and dynamic epidemiology of inflammatory bowel disease in Manitoba indicate the presence of important environmental risk factors, which warrants further investigation.

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Section: Discussionsupporting

confidence: 72%

Epidemiology of Crohn's Disease and Ulcerative Colitis in a Central Canadian Province: A Population-based Study

Bernstein

Blanchard

Rawsthorne

et al. 1999

American Journal of Epidemiology

612

405

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“…If the colectomy rate was higher in Leicester compared to other geographic areas, that would eliminate patients from the pool at risk for developing CRC and leave behind only very low‐risk individuals as controls. Probert’s study 37 demonstrates a similar colectomy rate for patients in Leicestershire (in particular Asians) compared with reported rates for St Marks 38 and North‐East Scotland 39 and thus this should not be a source of bias in our study.…”

Section: Discussionsupporting

confidence: 68%

Colorectal cancer prevention in ulcerative colitis: a case‐control study

Eaden

Abrams

Ekbom

et al. 2000

Aliment Pharmacol Ther

525

327

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“…Within Europe, the highest rates have been found in Scandinavian countries and Great Britain whereas Mediterranean areas appear to have lower rates. [6][7][8][9] In the Americas, a similar pattern has been suggested with the highest rates of IBD in the north-central United States and Canada. 10 Although at the present time there is no known explanation, it has been suggested that lower rates within more southern locations may be related to sunlight, indoor air pollution (urban versus rural), and/or transmissible agents.…”

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confidence: 59%