Nonspecific skin lesions in malignant lymphomas

Abstract

Objective: Clinical characteristics of the peculiarities of non-specific skin lesions with patients having malignant lymphomas (ML).Methods: 130 patients having malignant lymphomas were observed, 50 patients – having Hodgkin’s lymphomas, 38 patients - B-cell lymphomas and 42 patients – T-cell lymphomas.Results: Six main types of nonspecific lesions are defined among patients having malignant lymphomas: 1) skin lesions of auto toxic genesis, 2) skin lesions determined with vascular pathology, 3) skin lesions due to hemolysis and hemostatic disorders, 4) skin lesions of those having cryoglobulinemia/cryofibrinogenemia, 5) skin lesions due to metabolic disorder, 6) infectious diseases.Conclusions: Lesions of auto toxic genesis and infectious diseases prevail among nonspecific skin changes when having malignant lymphomas. Patients having Hodgkin’s lymphomas experience dermal itching more often. Among B-cell lymphomas skin lesions are more pathognomonic for chronic lymphocytic leukemia, among T-cell lymphomas – for fungal mycosis. Nonspecific skin lesions, having arisen before typical clinical picture of malignant lymphomas allow to suspect and diagnose the main illness on time. Disappearance of skin lesions against the background of specific therapy can bear evidence to the efficiency of the malignant lymphomas’ treatment.

Chronic monocytic leukemia with transformation into acute monocytic leukemia. Clinical case

“…По данным литературы прогностически неблагоприятными для течения острого миелоидного лейкоза являются высокий уровень лейкоцитов (> 100 000 / мм 3 ) на момент постановки диагноза, наличие предварительного миелодиспластического синдрома (МДС), нейролейкемии [19,25]. Установлена связь между развитием специфического поражения кожи при ОМЛ и неблагоприятным прогнозом продолжительности жизни пациентов [27,28].…”